(n.) The act of disposing, arranging, ordering, regulating, or transferring; application; disposal; as, the disposition of a man's property by will.
(n.) The state or the manner of being disposed or arranged; distribution; arrangement; order; as, the disposition of the trees in an orchard; the disposition of the several parts of an edifice.
(n.) Tendency to any action or state resulting from natural constitution; nature; quality; as, a disposition in plants to grow in a direction upward; a disposition in bodies to putrefaction.
(n.) Conscious inclination; propension or propensity.
(n.) Natural or prevailing spirit, or temperament of mind, especially as shown in intercourse with one's fellow-men; temper of mind.
(n.) Mood; humor.
Example Sentences:
(1) In view of its significant effects on drug metabolizing enzymes and clearance mechanisms, it is important to know its disposition characteristics.
(2) Models of the VMT nuclei were constructed to compare their size, shape and disposition across species.
(3) These marked steroid-induced changes in MS responsiveness could not be explained by altered pharmacokinetic disposition of morphine.
(4) The disposition of sulphadimidine (15 mg kg-1 orally) was investigated in six chronic osteoarthritis patients (four slow and two fast acetylators) prior to and 4 days following intra-articular administration of glucocorticoids.
(5) In the present paper, attention has been focused on the role of cytokines and the effects of the acute phase response on drug disposition in disease states (including the effect of anorexia on medicated feed intake and drug bioavailability).
(6) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(7) Avoidance coping was negatively related to dispositional optimism.
(8) The greatest problems appeared in diagnosing thrombosis of mesenterial vessels and acute appendicitis in cases with the retrocecal disposition of the vermiform process.
(9) Awareness of making dispositional inferences was only weakly correlated with disposition-cued recall.
(10) Current methods of evaluating the bioavailability of drugs with nonlinear disposition kinetics are based on specific pharmacokinetic models in contrast to the more rational model independent (structureless) area under the curve (AUC) and deconvolution methods used in linear pharmacokinetics.
(11) The disposition profiles of a new beta-adrenergic blocking drug, timolol, were investigated at 11 different times in normal individuals after a single oral dose.
(12) In order to compare the disposition of D-galactose and D-glucose in various organs of the rat, we have measured the amount of 14C-galactose and 14C-glucose present in the enteric canal, blood, muscle and liver, 2h.
(13) Leukocyte differentials from 468 emergency room patients were assessed for clinical value by determining their associations with diagnosis, disposition, therapy, and prognosis.
(14) To determine whether basal insulin supplementation in addition to lowering postabsorptive plasma glucose concentration also improves the postprandial pattern of glucose disposition, glucose metabolism after ingestion of a solid mixed meal was assessed in obese patients with NIDDM before and after treatment with ultralente and compared with glucose metabolism observed in nondiabetic subjects.
(15) Particular emphasis was placed on the relative spatial disposition of the tyramine moiety and the additional aromatic ring that occurs in both molecules.
(16) This paper reviews their pharmacologic disposition in man.
(17) The effects of modulation of liver microsomal sulphoxidation on the disposition kinetics of netobimin (NTB) metabolites were investigated in sheep.
(18) The changes in physicochemical properties due to introduction of a benzenesulfonyl group into the hydantoin ring may be responsible for the difference in the disposition between I and II.
(19) The disposition of amiloride was highly dependent on renal function, with higher plasma amiloride concentrations in the elderly reflecting diminished renal function.
(20) The clinical significance of the altered disposition of chloramphenicol is that administration at the usual dosing rate would lead to accumulation of the drug and eventual toxicity.
Notion
Definition:
() Mental apprehension of whatever may be known or imagined; an idea; a conception; more properly, a general or universal conception, as distinguishable or definable by marks or notae.
() A sentiment; an opinion.
() Sense; mind.
() An invention; an ingenious device; a knickknack; as, Yankee notions.
() Inclination; intention; disposition; as, I have a notion to do it.
Example Sentences:
(1) The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally.
(2) This procedure generated a number of VI-like effects, supporting the notion that VI behavior can be construed as a special case of an interaction between the organism's function relating reinforcement susceptibilities to chain length and the experimenter's function relating probabilities of reinforcement to chain length.
(3) Even if it does not always provide the solution to a particularly delicate problem, which is often of vital importance, it provides data which, modifiable and better used, should provide an adequate notion of the anatomical and physiopathological state in aortic stenosis.
(4) Though the concept of phase, known also as focus, is a very helpful notion, its empirical foundation is yet very weak.
(5) At least any notion that this tournament had meant little to the European champions can be dispelled.
(6) A role for cAMP in the process of LHRH release was suggested several years ago, but only recently has the validity of this notion come under close scrutiny.
(7) The notion of life-threatening dermatoses may seem to be a contradiction in terms, but in fact there are a number of serious dermatologic conditions that require prompt attention to prevent fatal consequences.
(8) Studies of E1A support the notion that small DNA tumour viruses target cellular pathways at key points that are amenable to regulation.
(9) If figurative language is defined as involving intentional violation of conceptual boundaries in order to highlight some correspondence, one must be sure that children credited with that competence have (1) the metacognitive and metalinguistic abilities to understand at least some of the implications of such language (Lakoff & Johnson, 1980; Nelson, 1974; Nelson & Nelson, 1978), (2) a conceptual organization that entails the purportedly violated conceptual boundaries (Lange, 1978), and (3) some notion of metaphoric tension as well as ground.
(10) These results emphasize the potential importance of LPL-mediated lipid assimilation in the metabolic events that lead to energy production in response to environmental stresses and lend support to the notion that the regulation of LPL activity is tissue specific.
(11) There is much conflicting immunological and viral data about the causes of chronic fatigue syndrome (CFS); some findings support the notion that CFS may be due to one or more immune disorders that have resulted from exposure to an infectious agent.
(12) Some journalists are uneasy at this notion of keeping an audit trail of thinking, authority and pre-publication decision-making?
(13) These results support the notion that ACT is acting on a component of the active assembled NADPH oxidase complex.
(14) A formal notion of relatability is defined, specifying which physically given edges leading into discontinuities can be connected to others by interpolated edges.
(15) This suggests that perhaps the notion of basic emotions will not lead to significant progress in the field.
(16) It has been established that the structure of depressive phases in sluggish simple schizophrenia includes specific psychopathological signs heralding defect formation and united by the notion "transitory syndrome".
(17) The differential response of the multiple H1 variants with regard to their synthesis and turnover is consistent with this notion.
(18) The experimental observations, coupled with several mathematical computations, do not support the notion that botulinum toxin is an acetylcholinesterase inhibitor.
(19) There is initial evidence that this variable dependency of RVD on Ca2+ may reflect, in large part, a variable Ca2+ threshold of RVD processes, although this notion has not been fully investigated.
(20) Besides the notion of psychosomatic medicine as a way of viewing, there is need of a definition of so-called psychosomatic diseases from the aspect of demarcation against general bio-psycho-social interactions.