(n.) The act of disposing, arranging, ordering, regulating, or transferring; application; disposal; as, the disposition of a man's property by will.
(n.) The state or the manner of being disposed or arranged; distribution; arrangement; order; as, the disposition of the trees in an orchard; the disposition of the several parts of an edifice.
(n.) Tendency to any action or state resulting from natural constitution; nature; quality; as, a disposition in plants to grow in a direction upward; a disposition in bodies to putrefaction.
(n.) Conscious inclination; propension or propensity.
(n.) Natural or prevailing spirit, or temperament of mind, especially as shown in intercourse with one's fellow-men; temper of mind.
(n.) Mood; humor.
Example Sentences:
(1) In view of its significant effects on drug metabolizing enzymes and clearance mechanisms, it is important to know its disposition characteristics.
(2) Models of the VMT nuclei were constructed to compare their size, shape and disposition across species.
(3) These marked steroid-induced changes in MS responsiveness could not be explained by altered pharmacokinetic disposition of morphine.
(4) The disposition of sulphadimidine (15 mg kg-1 orally) was investigated in six chronic osteoarthritis patients (four slow and two fast acetylators) prior to and 4 days following intra-articular administration of glucocorticoids.
(5) In the present paper, attention has been focused on the role of cytokines and the effects of the acute phase response on drug disposition in disease states (including the effect of anorexia on medicated feed intake and drug bioavailability).
(6) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(7) Avoidance coping was negatively related to dispositional optimism.
(8) The greatest problems appeared in diagnosing thrombosis of mesenterial vessels and acute appendicitis in cases with the retrocecal disposition of the vermiform process.
(9) Awareness of making dispositional inferences was only weakly correlated with disposition-cued recall.
(10) Current methods of evaluating the bioavailability of drugs with nonlinear disposition kinetics are based on specific pharmacokinetic models in contrast to the more rational model independent (structureless) area under the curve (AUC) and deconvolution methods used in linear pharmacokinetics.
(11) The disposition profiles of a new beta-adrenergic blocking drug, timolol, were investigated at 11 different times in normal individuals after a single oral dose.
(12) In order to compare the disposition of D-galactose and D-glucose in various organs of the rat, we have measured the amount of 14C-galactose and 14C-glucose present in the enteric canal, blood, muscle and liver, 2h.
(13) Leukocyte differentials from 468 emergency room patients were assessed for clinical value by determining their associations with diagnosis, disposition, therapy, and prognosis.
(14) To determine whether basal insulin supplementation in addition to lowering postabsorptive plasma glucose concentration also improves the postprandial pattern of glucose disposition, glucose metabolism after ingestion of a solid mixed meal was assessed in obese patients with NIDDM before and after treatment with ultralente and compared with glucose metabolism observed in nondiabetic subjects.
(15) Particular emphasis was placed on the relative spatial disposition of the tyramine moiety and the additional aromatic ring that occurs in both molecules.
(16) This paper reviews their pharmacologic disposition in man.
(17) The effects of modulation of liver microsomal sulphoxidation on the disposition kinetics of netobimin (NTB) metabolites were investigated in sheep.
(18) The changes in physicochemical properties due to introduction of a benzenesulfonyl group into the hydantoin ring may be responsible for the difference in the disposition between I and II.
(19) The disposition of amiloride was highly dependent on renal function, with higher plasma amiloride concentrations in the elderly reflecting diminished renal function.
(20) The clinical significance of the altered disposition of chloramphenicol is that administration at the usual dosing rate would lead to accumulation of the drug and eventual toxicity.
Strain
Definition:
(n.) Race; stock; generation; descent; family.
(n.) Hereditary character, quality, or disposition.
(n.) Rank; a sort.
(a.) To draw with force; to extend with great effort; to stretch; as, to strain a rope; to strain the shrouds of a ship; to strain the cords of a musical instrument.
(a.) To act upon, in any way, so as to cause change of form or volume, as forces on a beam to bend it.
(a.) To exert to the utmost; to ply vigorously.
(a.) To stretch beyond its proper limit; to do violence to, in the matter of intent or meaning; as, to strain the law in order to convict an accused person.
(a.) To injure by drawing, stretching, or the exertion of force; as, the gale strained the timbers of the ship.
(a.) To injure in the muscles or joints by causing to make too strong an effort; to harm by overexertion; to sprain; as, to strain a horse by overloading; to strain the wrist; to strain a muscle.
(a.) To squeeze; to press closely.
(a.) To make uneasy or unnatural; to produce with apparent effort; to force; to constrain.
(a.) To urge with importunity; to press; as, to strain a petition or invitation.
(a.) To press, or cause to pass, through a strainer, as through a screen, a cloth, or some porous substance; to purify, or separate from extraneous or solid matter, by filtration; to filter; as, to strain milk through cloth.
(v. i.) To make violent efforts.
(v. i.) To percolate; to be filtered; as, water straining through a sandy soil.
(n.) The act of straining, or the state of being strained.
(n.) A violent effort; an excessive and hurtful exertion or tension, as of the muscles; as, he lifted the weight with a strain; the strain upon a ship's rigging in a gale; also, the hurt or injury resulting; a sprain.
(n.) A change of form or dimensions of a solid or liquid mass, produced by a stress.
(n.) A portion of music divided off by a double bar; a complete musical period or sentence; a movement, or any rounded subdivision of a movement.
(n.) Any sustained note or movement; a song; a distinct portion of an ode or other poem; also, the pervading note, or burden, of a song, poem, oration, book, etc.; theme; motive; manner; style; also, a course of action or conduct; as, he spoke in a noble strain; there was a strain of woe in his story; a strain of trickery appears in his career.
(1) These variants may serve as useful gene markers in alcohol research involving animal model studies with inbred strains in mice.
(2) None of the strains was found to be positive for cytotoxic enterotoxin in the GM1-ELISA.
(3) They are going to all destinations.” Supplies are running thin and aftershocks have strained nerves in the city.
(4) In contrast, resting cells of strain CHA750 produced five times less IAA in a buffer (pH 6.0) containing 1 mM-L-tryptophan than did resting cells of the wild-type, illustrating the major contribution of TSO to IAA synthesis under these conditions.
(5) We were able to detect genetic recombination between vaccine strains of PRV following in vitro or in vivo coinoculation of 2 strains of PRV.
(6) All of the strains examined were motile and hemolytic and produced lipase and liquid gelatin.
(7) The taxonomic relationship of strains H4-14 and 25a with previously described Xanthobacter strains was studied by numerical classification.
(8) Whereas strain Ga-1 was practically avirulent for mice, strain KL-1 produced death by 21 days in 50% of the mice inoculated.
(9) These results suggest that the pelvic floor is affected by progressive denervation but descent during straining tends to decrease with advancing age.
(10) We also show that the gene of the main capsid protein is expressed from its own promoter in an Escherichia coli strain.
(11) Sequence variation in the gp116 component of cytomegalovirus envelope glycoprotein B was examined in 11 clinical strains and compared with variation in gp55.
(12) By hybridization studies, three plasmids in two forms (open circular and supercoiled) were detected in the strain A24.
(13) In addition, the fact that microheterogeneity may occur without limit in the mannans of the strains suggests that antibodies with unlimited diverse specificities are produced directed against these antigenic varieties as well.
(14) Strains isolated from the environment and staff were not implicated.
(15) The compressive strength of bone is proportional to the square of the apparent density and to the strain rate raised to the 0.06 power.
(16) Escherichia enterotoxigenic strains, Yersinia enterocolitica and Salmonella typhimurium virulent strains, Campylobacter jejuni clinical isolates possess more pronounced capacity for adhesion to enteric cells of Peyer's plaques than to other types of epithelial cells, which may be of importance in the pathogenesis of these infections.
(17) These sequences are also conserved in the same arrangement in minor sequence classes of minicircles from this strain.
(18) The isoelectric points (pI) of E1 and E2 for all VEE strains studied were approx.
(19) One rat strain (TAS) is susceptible to the anticoagulant and lethal effects of warfarin and the other two strains are homozygous for warfarin resistance genes from either wild Welsh (HW) or Scottish (HS) rats.
(20) In these bitches, a strain of E coli identical to the strain in the infected uterus was isolated.