(n.) A binary compound of sulphur containing two atoms of sulphur in each molecule; -- formerly called disulphuret. Cf. Bisulphide.
Example Sentences:
(1) Brief digestion at neutral pH without reduction produced a molecule in which the Fab and Fc fragments were still linked by a pair of labile disulphide bridges, and the Fc fragment released by cleaving these bonds, called 1Fc fragment, contained a portion of the ;hinge' region including an interchain disulphide bridge.
(2) The reactivity of the three disulphide bridges of insulin towards sodium sulphite was studied by amperometric titration of the liberated thiol groups.
(3) Limited trypsin digestion of purified platelet GPIIIa yielded a mixture of two-chain molecules comprised of an N-terminal fragment disulphide-bonded to one of four fragments, which began at residues 299, 303, 353 or 423.
(4) No disulphide bonds were observed in the subunit association.
(5) IPNS was rapidly inhibited by the thiol-blocking reagents N-ethylmaleimide and 2,2'- and 4,4'-dipyridyl disulphide, but not by 5,5'-dithiobis-(2-nitrobenzoic acid) in the same concentration.
(6) The symmetrical reagent 5,5'-dithiobis-(1-methyltetrazole) activates mitochondrial aldehyde dehydrogenase approximately 4-fold, whereas the smaller related compound methyl l-methyltetrazol-5-yl disulphide is a potent inactivator.
(7) Based on an understanding of the voltammetric behaviour of these biological molecules, which rely on the presence of the disulphide groups within their molecular structure for their electroactivity, it has been postulated that binding of cisplatin to these molecules occurs at the disulphide bond.
(8) Instead it suggests that carbon disulphide has some type of reversible, direct cardiotoxic or thrombotic effect.
(9) The hemolytic toxin (HT), isolated from the sea anemone Stoichactis helianthus, has been conjugated to a MAb directed against carcinoembryonic antigen (CEA), by means of an artificial disulphide bridge.
(10) This finding is supported by our having obtained similar results in PMN and whole blood with catalase (C), glutathione (GSH) and N-acetylcysteine (NAC) but not with penicillamine disulphide (PSSP) or superoxide dismutase.
(11) D-Penicillamine (D-pen), a thiol with antirheumatic activity, forms a mixed disulphide with albumin in vivo.
(12) The molecule, a homodimer formed by disulphide-linked chains of relative molecular mass (Mr) 140,000, is identified by a mouse monoclonal alloantibody called BP-1.
(13) One mole of oxygen is consumed for every 2 moles of dithiothreitol oxidized and the product is shown by spectral studies to be the intramolecular disulphide.
(14) The islet thiol:protein-disulphide oxidoreductase activity (EC 1.8.4.2) was apparently unchanged, whereas washing temperatures lower than 37 degrees C resulted in a diminished insulin content.
(15) In addition, there has been considerable concern over the lability of the disulphide bond between the toxophore and ligand components in vivo due to the action of disulphide reductases.
(16) The Cys 509-->Arg substitution eliminates an intramolecular disulphide bridge formed by Cys 509 and Cys 695 which is important to maintain the configuration of vWF functional domains that interact with platelet glycoprotein Ib-IX.
(17) This species appeared to consist of two disulphide-linked components each of Mr 50,000, with an additional 50,000-Mr chain attached non-covalently.
(18) Some regions of the delta subunit molecule, including the region containing the putative disulphide bridge and that encompassing the clustered putative transmembrane segments M1, M2 and M3, are relatively well conserved between calf and Torpedo.
(19) Whereas toxin CM-11 contains 65 amino acid residues and five intrachain disulphide bridges, toxin CM-2 and CM-12 comprise, respectively, 61 and 62 residues but both contain four disulphide bridges.
(20) In an attempt to define the 3D structure of this domain, the disulphide linkage pattern was determined and shown to be Cys 1-4, Cys 2-5 and Cys 3-6 in contradiction to an earlier report.
Sulphide
Definition:
(n.) A binary compound of sulphur, or one so regarded; -- formerly called sulphuret.
Example Sentences:
(1) Sulphides, which possibly form on silver alloys, showed cytotoxicity.
(2) Bacteria of the genus Thiobacillus can obtain energy from the chemolithotrophic oxidation of inorganic sulphur and its compounds (sulphide, thiosulphate and polythionates) and use this energy to support autotrophic growth on carbon dioxide.
(3) Elevations in blood methanethiol and dimethyl sulphide concentration in children with congenital hypermethioninaemia were not associated with any neurological or electroencephalographic features of hepatic coma.
(4) No significant changes in respiratory function or bronchial responsiveness related to exposure to hydrogen sulphide in the pulp mill workers were found.
(5) Therapeutic procedure are based either on physical media: infra-red rays, gamma-rays, electric fields for the transformation of temperature or using chemical mixtures containing methyl bromide, carbon tetrachloride and hydrogen sulphide.
(6) produced strong rotten, fishy, hydrogen sulphide off-odours.
(7) Although it has a level of hepatic fixation which is less than that of certain sulphide complexes of technetium, the authors feel that it appears to provide a better relfection of the colloidopexic function of the liver.
(8) Ammonia, methane, hydrogen sulphide and methyl mercaptides were analyzed in the atmospheres of 16 Finnish municipal waste water treatment plants and in 18 pumping stations.
(9) Both TPM and chlorhexidine brought about significant decreases in volatile sulphides (P less than 0.05) as compared to the placebo group.
(10) It is a molybdenum hydroxylase containing 1.6 mol of FAD, 7.3 mol of Fe, 8.3 mol of acid-labile sulphide and 1.3 mol of Mo per mol of enzyme.
(11) A single and chronic inhalation exposure to a complex of chemical substances being part of hydrogen sulphide-containing natural gas (hydrogen sulphide, hydrocarbon, mercaptan, sulphur dioxide) results in a decline in humoral indicators of non-specific body resistance.
(12) The oxidation of sulphide in cell-free extracts proceeds most likely to polysulphanes or to elemental sulphur, depending on the conditions.
(13) Concentration-time interactions were investigated in young male and female Sprague-Dawley, Long Evans and Fischer-344 rats exposed to hydrogen sulphide for two, four or six hours.
(14) The content of hydrogen sulphide reached 6.8 mg per litre which resulted in a change of the ecological environment in the lake.
(15) The flow of sulphide, sulphate, microbial S and non-microbial organic S from the abomasum was estimated using 103Ru and 51Cr.
(16) Addition of sulphide to rumen contents did not result in significant changes in the distribution of Cu between the fluid and solid phases, or in the solubility of Cu in TCA.
(17) The Km values for sulphide and O-acetylserine are 2.7 - 10(-3) and 1.25 - 10(-3) M, respectively.
(18) The method is based on the disintegration of S-methyl methionine in the alkaline medium to form equimolecular quantities of dimethyl sulphide and homoserine.
(19) Official local autopsy reports on 12 alleged victims showed fatal levels of the poisonous gas hydrogen sulphide, one of the waste's lethal byproducts.
(20) Using the histochemical Timm sulphide silver method, a strain-specific, increased stainability of the cell bodies of the dentate granule cells and the hippocampal pyramidal cells was observed in the inbred Kyoto rat.