(n.) A binary compound of sulphur containing two atoms of sulphur in each molecule; -- formerly called disulphuret. Cf. Bisulphide.
Example Sentences:
(1) Brief digestion at neutral pH without reduction produced a molecule in which the Fab and Fc fragments were still linked by a pair of labile disulphide bridges, and the Fc fragment released by cleaving these bonds, called 1Fc fragment, contained a portion of the ;hinge' region including an interchain disulphide bridge.
(2) The reactivity of the three disulphide bridges of insulin towards sodium sulphite was studied by amperometric titration of the liberated thiol groups.
(3) Limited trypsin digestion of purified platelet GPIIIa yielded a mixture of two-chain molecules comprised of an N-terminal fragment disulphide-bonded to one of four fragments, which began at residues 299, 303, 353 or 423.
(4) No disulphide bonds were observed in the subunit association.
(5) IPNS was rapidly inhibited by the thiol-blocking reagents N-ethylmaleimide and 2,2'- and 4,4'-dipyridyl disulphide, but not by 5,5'-dithiobis-(2-nitrobenzoic acid) in the same concentration.
(6) The symmetrical reagent 5,5'-dithiobis-(1-methyltetrazole) activates mitochondrial aldehyde dehydrogenase approximately 4-fold, whereas the smaller related compound methyl l-methyltetrazol-5-yl disulphide is a potent inactivator.
(7) Based on an understanding of the voltammetric behaviour of these biological molecules, which rely on the presence of the disulphide groups within their molecular structure for their electroactivity, it has been postulated that binding of cisplatin to these molecules occurs at the disulphide bond.
(8) Instead it suggests that carbon disulphide has some type of reversible, direct cardiotoxic or thrombotic effect.
(9) The hemolytic toxin (HT), isolated from the sea anemone Stoichactis helianthus, has been conjugated to a MAb directed against carcinoembryonic antigen (CEA), by means of an artificial disulphide bridge.
(10) This finding is supported by our having obtained similar results in PMN and whole blood with catalase (C), glutathione (GSH) and N-acetylcysteine (NAC) but not with penicillamine disulphide (PSSP) or superoxide dismutase.
(11) D-Penicillamine (D-pen), a thiol with antirheumatic activity, forms a mixed disulphide with albumin in vivo.
(12) The molecule, a homodimer formed by disulphide-linked chains of relative molecular mass (Mr) 140,000, is identified by a mouse monoclonal alloantibody called BP-1.
(13) One mole of oxygen is consumed for every 2 moles of dithiothreitol oxidized and the product is shown by spectral studies to be the intramolecular disulphide.
(14) The islet thiol:protein-disulphide oxidoreductase activity (EC 1.8.4.2) was apparently unchanged, whereas washing temperatures lower than 37 degrees C resulted in a diminished insulin content.
(15) In addition, there has been considerable concern over the lability of the disulphide bond between the toxophore and ligand components in vivo due to the action of disulphide reductases.
(16) The Cys 509-->Arg substitution eliminates an intramolecular disulphide bridge formed by Cys 509 and Cys 695 which is important to maintain the configuration of vWF functional domains that interact with platelet glycoprotein Ib-IX.
(17) This species appeared to consist of two disulphide-linked components each of Mr 50,000, with an additional 50,000-Mr chain attached non-covalently.
(18) Some regions of the delta subunit molecule, including the region containing the putative disulphide bridge and that encompassing the clustered putative transmembrane segments M1, M2 and M3, are relatively well conserved between calf and Torpedo.
(19) Whereas toxin CM-11 contains 65 amino acid residues and five intrachain disulphide bridges, toxin CM-2 and CM-12 comprise, respectively, 61 and 62 residues but both contain four disulphide bridges.
(20) In an attempt to define the 3D structure of this domain, the disulphide linkage pattern was determined and shown to be Cys 1-4, Cys 2-5 and Cys 3-6 in contradiction to an earlier report.
Sulphur
Definition:
(n.) A nonmetallic element occurring naturally in large quantities, either combined as in the sulphides (as pyrites) and sulphates (as gypsum), or native in volcanic regions, in vast beds mixed with gypsum and various earthy materials, from which it is melted out. Symbol S. Atomic weight 32. The specific gravity of ordinary octohedral sulphur is 2.05; of prismatic sulphur, 1.96.
(n.) Any one of numerous species of yellow or orange butterflies of the subfamily Pierinae; as, the clouded sulphur (Eurymus, / Colias, philodice), which is the common yellow butterfly of the Eastern United States.
Example Sentences:
(1) That suggests they are being replenished by sulphur dioxide, most probably from volcanoes.
(2) Sulphuric acid fluorescence is used for quantitation and specificity is achieved by the addition of tritiated oestrone to the urine hydrolysate.
(3) Liver scintigraphy with 67-Ga citrate and alphafetoprotein (afp) determinations in the serum were carried out in 84 patients with liver mass lesions in the preceding sulphur colloid scans.
(4) The use of sulphur-containing amino acids and 2-deoxyglucose in growth media led to impaired cell wall synthesis and rendered cells very susceptible to treatment with mercapto-ethanol and various lytic enzymes.
(5) The molecular mass (5988 Da) of the native rubredoxin has been measured by electrospray-ionization m.s., thus establishing the applicability of the technique to this type of iron-sulphur protein.
(6) Attention is drawn to the shortcomings in our current knowledge of the scale of turnover of the sulphur cycle and of our understanding of the microorganisms involved in specialized environments.
(7) N-Methylformamide extracts of acid-treated precipitated VFe protein of the V-nitrogenase of Azotobacter chroococcum are yellow-brown in colour and contain vanadium, iron and acid-labile sulphur in the approximate proportions 1:6:5.
(8) Here we show that a farnesyl moiety is attached to a sulphur atom of the C-terminal cysteine of T gamma-2 (active form), a part of which is additionally methyl-esterified at the alpha-carboxyl group.
(9) Erabutoxin a was partially hydrolysed with enzymes and sulphuric acid and the resulting peptides were separated from each other by column chromatography and paper electrophoresis.
(10) NADH:ubiquinone reductase, the respiratory chain complex I of mitochondria, consists of some 25 nuclear-encoded and seven mitochondrially encoded subunits, and contains as redox groups one FMN, probably one internal ubiquinone and at least four iron-sulphur clusters.
(11) Bacteria of the genus Thiobacillus can obtain energy from the chemolithotrophic oxidation of inorganic sulphur and its compounds (sulphide, thiosulphate and polythionates) and use this energy to support autotrophic growth on carbon dioxide.
(12) Bacteriophage mu2 is inactivated by both mono- and di-functional sulphur mustards at relatively low extents of alkylation.
(13) The study of amino acid pattern shows that sulphur containing amino acids are limiting to almost the same degree in meat and meat soy blend.
(14) In a case in which ovarian biopsy at laparotomy revealed typical actinomycotic "sulphur granules" and Actinomyces israelii was diagnosed, standard Actinomyces israelii cytoplasmic antigens and circulating C1-binding immune complexes were found in the patient's serum when it was tested by counterimmunoelectrophoresis.
(15) Experiments were performed in a cylinder full of beads open at one end and closed at the other in which a mixture of oxygen with helium or argon or sulphur hexafluoride could diffuse with ambient air through the open end.
(16) The results obtained indicated that both the sulphydration and trans-sulphuration pathways were operating.
(17) This effect may add to other factors decreasing sulphur availability in critically ill patients, and simultaneous administration of thiosulphate is therefore recommended to ensure a safe SNP treatment during and after coronary bypass operations.
(18) (4) There is no specific therapy for poisoning by sulphur mustard.
(19) Among various acetylated proteins, proteins insoluble in 0.1m-sulphuric acid have the highest radioactivity.
(20) Desulfovibrio africanus ferredoxin III is a monomeric protein (Mr 6585) containing seven cysteine residues and 7-8 iron atoms and 6-8 atoms of acid-labile sulphur.