(n.) A quadruped of the genus Canis, esp. the domestic dog (C. familiaris).
(n.) A mean, worthless fellow; a wretch.
(n.) A fellow; -- used humorously or contemptuously; as, a sly dog; a lazy dog.
(n.) One of the two constellations, Canis Major and Canis Minor, or the Greater Dog and the Lesser Dog. Canis Major contains the Dog Star (Sirius).
(n.) An iron for holding wood in a fireplace; a firedog; an andiron.
(n.) A grappling iron, with a claw or claws, for fastening into wood or other heavy articles, for the purpose of raising or moving them.
(n.) An iron with fangs fastening a log in a saw pit, or on the carriage of a sawmill.
(n.) A piece in machinery acting as a catch or clutch; especially, the carrier of a lathe, also, an adjustable stop to change motion, as in a machine tool.
(v. t.) To hunt or track like a hound; to follow insidiously or indefatigably; to chase with a dog or dogs; to worry, as if by dogs; to hound with importunity.
Example Sentences:
(1) We conclude that chronic emphysema produced in dogs by aerosol administration of papain results in elevated pulmonary artery pressure, which is characterized pathologically by medial hypertrophy of small pulmonary arteries.
(2) The combined immediate and delayed responses to fleas in the dog are as observed by other investigators in man and guinea pigs.
(3) In dogs, cibenzoline given i.v., had no effects on the slow response systems, probably because of sympathetic nervous system intervention since the class 4 effects of cibenzoline appeared after beta-adrenoceptor blockade.
(4) It was shown in experiments on four dogs by the conditioned method that the period of recovery of conditioned activity after one hour ether anaesthesia tested 7 to 7.5 days.
(5) Dialysis of dog plasma against an artificial c.s.f.
(6) For similar inotropic responses, normo- and hyperkalaemic dogs had similar levels of (Na+, K+)-ATPase inhibition and microsomal-bound digoxin.
(7) Complete heart block was produced in 20 of 20 dogs.
(8) The dog and the pig also have an endoperoxide-sensitive constrictor system activated by the 11,9-(epoxymethano) analogue of PGH2 and, of particular note, ICI 79939 and its 11-oxo analogue.
(9) All of this in the same tones of weary nonchalance you might use to stop the dog nosing around in the bin.
(10) One hundred and twelve dogs, including twenty C3-deficient dogs, were studied over a period of 6 years.
(11) From the present results it is concluded that secretion of extrapancreatic glucagon increased in response to arginine infusion in the diabetic state, both alloxan diabetic dogs and one-week post-pancreatectomized dogs.
(12) The effect of pO(2) was studied in a further nine dogs.
(13) The effects of tachycardia caused by ectopic right or left ventricular stimulation on ventricular recovery potentials were studied in 30 dogs.
(14) Stimulation with these electrodes were effective for inducing voiding with little residual volume after the recovery of bladder reflexes, 3 weeks after experimental spinal cord injury in the dog.
(15) A neodymium YAG (Nd:YAG) laser was evaluated in a dog ulcer model used in the same manner as is recommended for bleeding patients (power 55 W, divergence angle 4 degrees, with CO2 gas-jet assistance).
(16) Hollywood legend has it that, at the first Academy awards in 1929, Rin Tin Tin the dog won most votes for best actor.
(17) Liver bloodflow remained unchanged in AS dogs, but hepatic alanine uptake nearly tripled (p less than 0.01) and hepatic glucose production increased by 60% (p less than 0.05).
(18) Affected dogs were from ten breeds and their average age was eight years.
(19) Though three of these presumable metabolites could slightly inhibit the binding of [3H]-KW-3049, they were not detected in rat and dog plasma at 0.5 h after oral administration of KW-3049.
(20) Temelastine produces these species-specific changes by enhancing thyroxine clearance from the circulation in the rat, but not in the dog or mouse.
Lurcher
Definition:
(n.) One that lurches or lies in wait; one who watches to pilfer, or to betray or entrap; a poacher.
(n.) One of a mongrel breed of dogs said to have been a cross between the sheep dog, greyhound, and spaniel. It hunts game silently, by scent, and is often used by poachers.
(n.) A glutton; a gormandizer.
Example Sentences:
(1) These results indicate that in spite of cerebellar degeneration and ataxia, lurcher mutants are not impaired in all tests measuring motor function.
(2) Immunocytochemical analysis of aggregation chimeras made using either of the mutants, Lurcher or Purkinje cell degeneration, previously showed that only Bergmann glia close to surviving Purkinje cells expressed an apparently normal level of the enzyme, glycerol-3-phosphate dehydrogenase (GPDH) (Fisher and Mullen, 1988).
(3) Lurcher Purkinje cells, in contrast, receive scattered contacts by GAD-IR puncta and possess a "cap" of such elements surrounding the primary dendrite and apical soma.
(4) Lurcher mice show 100% degeneration of Purkinje cells, starting during the second postnatal week, while staggerer mice show reduced numbers of Purkinje cells in a distinctive mediolateral distribution from the time of birth, with the remainder grossly stunted.
(5) We conclude that the Lurcher cerebellum is particularly sensitive to thyroid hormone, and that it responds to low levels of hyperthyroidism in a distinct way.
(6) It was found that, in comparison to littermate controls, the lurcher mutants alternated less often in a discrete two-trial procedure of spontaneous alternation and did not habituate to maze stimuli in a T-maze.
(7) The response of IP neurones in normal and Lurcher mice appear to be similar to those observed in the normal and experimentally cerebellar decorticate cat, respectively.
(8) These afferents maintain dense perisomatic nests around Purkinje cells, even in P13-15 lurchers.
(9) In the present study, we examined the IL-6 mRNA expression by stimulated peripheral macrophages of two cerebellar mutant mice, the staggerer and the lurcher mutants.
(10) It is concluded that the mossy fibre input to the cerebellum is intact in the Lurcher mutant mouse.
(11) In contrast, the lurcher cerebellum exhibited enzyme activity in both molecular and granular layers.
(12) This study examines the question of whether intrinsically defective mutant Lurcher Purkinje cells, which degenerate during postnatal weeks two to five, followed by later loss of granule cells are competent to respond to neonatal hyperthyroidism, which is known to cause premature differentiation of Purkinje cells and an acceleration of the peak of proliferation in granule cells in normal rodent cerebellum.
(13) Although they are normal in number, previous work from our laboratories has shown that when the genetically wild-type Purkinje cells are present in the mosaic environment of the lurcher chimeric mouse they develop a very unusual morphology.
(14) The response characteristics of interpositus neurones (IP) to sciatic nerve stimulation were studied in normal and Lurcher mutant mice under pentobarbitone anaesthesia.
(15) This proved incorrect and, indeed, the Purkinje cells in the lurcher chimeras show changes of a predominantly atrophic nature.
(16) Quantitative analysis of Golgi-Cox impregnated material reveals that in lurcher chimeras the Purkinje cell dendritic arbor is reduced by more than 60% compared to wild-type animals.
(17) In lurcher mice, Purkinje cells degenerate during the first few postnatal weeks, after receiving synaptic contacts from both inferior olivary neurons and granule cells.
(18) Lurcher is an autosomal dominant mutation in the mouse.
(19) Cerebella of Lurcher and control age-matched (from P8 to P16) mice were analysed by calbindin immunostaining, silver impregnation and quantitative electron microscopy.
(20) These benzodiazepine binding sites in washed homogenates or tissue sections displayed a gamma-aminobutyrate-induced enhancement of [3H]flunitrazepam binding which occurred to the same extent in both Lurcher and normal cerebellum, a facilitatory effect which could be blocked by the addition of bicuculline methobromide.