(v. i.) Feebleness or imbecility of understanding or mind, particularly in old age; the childishness of old age; senility; as, a venerable man, now in his dotage.
(v. i.) Foolish utterance; drivel.
(v. i.) Excessive fondness; weak and foolish affection.
Example Sentences:
(1) Instead, when I think of great skin I think of Katharine Hepburn in her dotage .
(2) The Miliband brothers, whom cartoonists still put in short trousers, are clearly not contemplating dotage just yet, and so surely their gooey professions of love should be set aside for the sterner dictates of combat.
(3) Indeed, Lord Hutton might even be criticised for proposing such a sweeping waiver for uniformed servicemen, who, he insists, must always be able to draw a pension at 60, even though his own figures show that most of them move on to other paid jobs, as opposed to a dependent dotage.
(4) In contrast to that bright 1990s vision of a future UK, it is, moreover, an old country, whose dotage is portrayed as a matter of crabby resentment, a place where there is a collective wish to lock all the doors.
(5) The choices we make for our children become lifestyle choices (with the result that they stay at home into their dotage, knowing their parents will make sure they have the right clothes, hair gel, TVs, iPods and iPads.
(6) Concerning the mother child relationship, there were elements of "anxiety" "dotage" "follow blindly" "disagreement".
(7) They can now happily carry on watching BBC4 into their dotage.
(8) For example in the peak years of his Manchester United dotage the phrase “Paul Scholes, he’s a bit overrated isn’t he?” was effectively unprintable, its publication likely to spark mob anger, civil unrest, punishable ultimately by being stabbed in the eye with a skewer by the Queen.
(9) The mothers of group B showed attitudes of dotage and anxiety, especially when their children were over 12 years of age and the seizures were not controlled.
(10) But there are no false notions of greatness here, the country will bask in a warm glow for weeks to come and today's kids will remember the winter of the South African World cup well into their dotage."
(11) Psychology Today reported at the end of last year that more than a third of us have a distant relationship with our brothers or sisters as adults because of a childhood rivalry that never fully dissipated, while any hopes of an ultimately long-term ceasefire tends to arrive only in our dotage.
Senility
Definition:
(n.) The quality or state of being senile; old age.
Example Sentences:
(1) Hyperopia was more common in younger persons, but senile cataract, macular degeneration and palpebral dermatochalasis or blepharochalasis were more common in older persons.
(2) Mucosal drying medications and senile salivary gland atrophy seemed to contribute to the high frequency of sicca in this population with a lesser proportion of the subjects demonstrating previously undiagnosed Sjögren's and possible Sjögren's syndrome.
(3) Key findings include a progressive degeneration of these cholinergic neurons characterized by the formation of immunoreactively atypical NFT, the loss of intraneuronal lipofuscin, a lack of senile plaque and beta-amyloid deposition within the basal forebrain, and end-stage gliosis without residual extracellular NFT.
(4) This finding is consistent with the hypothesis that the majority of deaths attributed to presenile dementia and the majority of deaths from senile dementia are the result of the same disease entity.
(5) Diagnoses like neuroses, alcoholism, and senile dementia produced many visits by few patients.
(6) Her mother had only senile pigmented modification of the fundus and her three daughters had mild macular pigmented changes, like "salt and pepper."
(7) The reduced effectiveness of protection by antibody against viruses which had caused influenza disease 20--30 years ago was conducive to the spread of influenza Al cases among middle-aged and senile population.
(8) Since the detailed molecular events leading to the formation of amyloid-containing senile plaques of the Alzheimer's disease (AD) brain are incompletely understood, the present studies were undertaken to address this issue using a combination of molecular and cytochemical approaches.
(9) Recently in senile dementia of Alzheimer type, neuronal loss of cholinergic neurons in the substantia innominata is described.
(10) Whereas markedly high values of 1, 25-(OH)2D in plasma were found in some cases of primary hyperparathyroidism with prominent bone resorption, relatively low values were seen in some patients with chronic renal failure, senile osteoporosis, osteomalacia and hypercalcemia due to bone metastasis.
(11) The ultrastructure of the water-clear cells of the parathyroid glands in the starved adult and senile animals almost resembled that of the control adult and senile animals.
(12) The study of the drugs effective in the treatment of cognitive deficits and memory loss associated with senile dementia of the Alzheimer's type--tacrine and amiridin, acetylcholinesterase inhibitor physostigmine and nootrop piracetam on uptake of 3H-serotonin (3H-5-HT), 3H-adrenaline (3H-AD), 3H-noradrenaline (3H-HA), 2H-dopamine (3H-DA), 3H-gamma-aminobutyric acid (3H-GABA), 3H-glutamic acid (3H-GLU), 3H-aspartic acid (3H-ASP) and 3H-glycine (3H-GLI) showed that tacrine and amiridin (5 x 10(-5) M) statistically significantly (P less than 0.05) inhibited the uptake of 3H-DA and 3H-5-HT.
(13) The results are as follows: The neurites of senile DRG cells appeared 7 days later than the neurites of neonatal DRG cells.
(14) Although a trend was observed for TMA-DPH mobility to parallel histopathologic severity in hippocampal specimens, the biophysical changes did not appear to reflect a loss of neuronal membranes relative to glial membranes or the presence of senile plaques or neurofibrillary tangles.
(15) Corticotropin-releasing hormone-immunoreactivity (CRH-IR) and CRH receptors (binding capacity and affinity) were measured in postmortem cortical areas from depressed subjects, two groups of senile dementia of the Alzheimer type (SDAT), and age-, sex-, and postmortem-delay-matched controls.
(16) Anti-beta-peptide stained cerebrovascular and plaque core amyloid in all AD cases as well as cerebrovascular amyloid and senile plaque core amyloid in five elderly CJD cases.
(17) Senile dementia and admission other than from the patient's own home, were factors associated with a poorer long term outcome.
(18) In this study 40 fragments of human skin from 4 groups were included: children, adults, aged people with lesions of senile keratosis and without lesions of senile keratosis.
(19) To examine the efficacy of cholinergic enhancement in senile dementia of the Alzheimer type (SDAT), oral physostigmine was given to eight patients in a cross-over trial of three dose levels and a matching placebo.
(20) Here the presence and distribution within senile plaques of various epitopes of the beta-amyloid precursor protein (APP) are compared with the distribution of A beta P itself and markers for plaque neurites.