(n.) Any animal, vegetable, or mineral substance used in the composition of medicines; any stuff used in dyeing or in chemical operations.
(n.) Any commodity that lies on hand, or is not salable; an article of slow sale, or in no demand.
(v. i.) To prescribe or administer drugs or medicines.
(v. t.) To affect or season with drugs or ingredients; esp., to stupefy by a narcotic drug. Also Fig.
(v. t.) To tincture with something offensive or injurious.
(v. t.) To dose to excess with, or as with, drugs.
Example Sentences:
(1) Previous use of the drug is found in more than 50 per cent of the patients, and it was often followed by a neglected side-effect.
(2) Disease stabilisation was associated with prolonged periods of comparatively high plasma levels of drug, which appeared to be determined primarily by reduced drug clearance.
(3) The significance of minor increases in the serum creatinine level must be recognized, so that modifications of drug therapy can be made and correction of possibly life-threatening electrolyte imbalances can be undertaken.
(4) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(5) Theophylline kinetics, as an in vivo probe for the potentially toxic cytochrome P-450I pathway of drug metabolism, were studied in 11 healthy volunteers and 11 patients with calcific chronic pancreatitis at Madras, South India.
(6) However, medicines have an important part to play, and it is now generally agreed that for the very poor populations medicines should be restricted to those on an 'essential drugs list' and should be made available as cheaply as possible.
(7) The ability of azelastine to influence antigen-induced contractile responses (Schultz-Dale phenomenon) in isolated tracheal segments of the guinea-pig was investigated and compared with selected antiallergic drugs and inhibitors of arachidonic acid metabolism.
(8) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(9) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(10) Some of those drugs are able to stimulate the macrophages, even in an aspecific way, via the gut associated lymphatic tissue (GALT), that is in connection with the bronchial associated lymphatic tissue (BALT).
(11) The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs.
(12) The results of the evaluation confirm that most problems seen by first level medical personnel in developing countries are simple, repetitive, and treatable at home or by a paramedical worker with a few safe, essential drugs, thus avoiding unnecessary visits to a doctor.
(13) Acquired drug resistance to INH, RMP, and EMB can be demonstrated in M. kansasii, and SMX in combination with other agents chosen on the basis of MIC determinations are effective in the treatment of disease caused by RMP-resistant M. kansasii.
(14) Further development of drug formulary concept was discussed, primarily for the drugs paid by the Health Insurance, as well as the unsatisfactory ADR reporting in Yugoslavia.
(15) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(16) The authors empirically studied the self-medication hypothesis of drug abuse by examining drug effects and motivation for drug use in 494 hospitalized drug abusers.
(17) Inadequate treatment, caused by a lack of drugs and poorly trained medical attendants, is also a major problem.
(18) To investigate the relationship between Helicobacter pylori infection and nonsteroidal anti-inflammatory drug (NSAID) intolerance and the effect of gold use on the seroprevalence of H. pylori.
(19) A remarkable deterioration of prognosis with increasing age rises the question whether treatment with cytotoxic drugs should be tried in patients more than 60 years old.
(20) It was concluded that metoclopramide and dexamethasone showed an excellent antiemetic effect on acute drug-induced emesis, as well as on delayed emesis, induced by cisplatin.
Line
Definition:
(n.) Flax; linen.
(n.) The longer and finer fiber of flax.
(v. t.) To cover the inner surface of; as, to line a cloak with silk or fur; to line a box with paper or tin.
(v. t.) To put something in the inside of; to fill; to supply, as a purse with money.
(v. t.) To place persons or things along the side of for security or defense; to strengthen by adding anything; to fortify; as, to line works with soldiers.
(v. t.) To impregnate; -- applied to brute animals.
(n.) A linen thread or string; a slender, strong cord; also, a cord of any thickness; a rope; a hawser; as, a fishing line; a line for snaring birds; a clothesline; a towline.
(n.) A more or less threadlike mark of pen, pencil, or graver; any long mark; as, a chalk line.
(n.) The course followed by anything in motion; hence, a road or route; as, the arrow descended in a curved line; the place is remote from lines of travel.
(n.) Direction; as, the line of sight or vision.
(n.) A row of letters, words, etc., written or printed; esp., a row of words extending across a page or column.
(n.) A short letter; a note; as, a line from a friend.
(n.) A verse, or the words which form a certain number of feet, according to the measure.
(n.) Course of conduct, thought, occupation, or policy; method of argument; department of industry, trade, or intellectual activity.
(n.) That which has length, but not breadth or thickness.
(n.) The exterior limit of a figure, plat, or territory; boundary; contour; outline.
(n.) A threadlike crease marking the face or the hand; hence, characteristic mark.
(n.) Lineament; feature; figure.
(n.) A straight row; a continued series or rank; as, a line of houses, or of soldiers; a line of barriers.
(n.) A series or succession of ancestors or descendants of a given person; a family or race; as, the ascending or descending line; the line of descent; the male line; a line of kings.
(n.) A connected series of public conveyances, and hence, an established arrangement for forwarding merchandise, etc.; as, a line of stages; an express line.
(n.) A circle of latitude or of longitude, as represented on a map.
(n.) The equator; -- usually called the line, or equinoctial line; as, to cross the line.
(n.) A long tape, or a narrow ribbon of steel, etc., marked with subdivisions, as feet and inches, for measuring; a tapeline.
(n.) A measuring line or cord.
(n.) That which was measured by a line, as a field or any piece of land set apart; hence, allotted place of abode.
(n.) Instruction; doctrine.
(n.) The proper relative position or adjustment of parts, not as to design or proportion, but with reference to smooth working; as, the engine is in line or out of line.
(n.) The track and roadbed of a railway; railroad.
(n.) A row of men who are abreast of one another, whether side by side or some distance apart; -- opposed to column.
(n.) The regular infantry of an army, as distinguished from militia, guards, volunteer corps, cavalry, artillery, etc.
(n.) A trench or rampart.
(n.) Dispositions made to cover extended positions, and presenting a front in but one direction to an enemy.
(n.) Form of a vessel as shown by the outlines of vertical, horizontal, and oblique sections.
(n.) One of the straight horizontal and parallel prolonged strokes on and between which the notes are placed.
(n.) A number of shares taken by a jobber.
(n.) A series of various qualities and values of the same general class of articles; as, a full line of hosiery; a line of merinos, etc.
(n.) The wire connecting one telegraphic station with another, or the whole of a system of telegraph wires under one management and name.
(n.) The reins with which a horse is guided by his driver.
(n.) A measure of length; one twelfth of an inch.
(v. t.) To mark with a line or lines; to cover with lines; as, to line a copy book.
(v. t.) To represent by lines; to delineate; to portray.
(v. t.) To read or repeat line by line; as, to line out a hymn.
(v. t.) To form into a line; to align; as, to line troops.
Example Sentences:
(1) Similar experimental manipulation has yielded in vitro lines established from avian B-cell lymphomas expressing elevated levels of c-myc or v-rel.
(2) The effect of insulin-like growth factor I (IGF-I) on growth of small cell lung cancer (SCLC) cell lines was studied.
(3) The liver metastasis was produced by intrasplenic injection of the fluid containing of KATOIII in nude mouse and new cell line was established using the cells of metastatic site.
(4) After stimulation with lipopolysaccharide and calcium ionophore A23187, culture supernatants of clones c18A and c29A showed cytotoxic activity against human melanoma A375 Met-Mix and other cell lines which were resistant to the tumor necrosis factor, lymphotoxin and interleukin 1.
(5) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(6) On the other hand, human IL-9, which is a homologue to murine P40, was cloned from a cDNA library prepared with mRNA isolated from PHA-induced T-cell line (C5MJ2).
(7) However, four of ten young adult outer arm (relatively sun-exposed) and one of ten young adult inner arm (relatively sun-protected) fibroblasts lines increased their saturation density in response to retinoic acid.
(8) The promoters of the adenovirus 2 major late gene, the mouse beta-globin gene, the mouse immunoglobulin VH gene and the LTR of the human T-lymphotropic retrovirus type I were tested for their transcription activities in cell-free extracts of four cell lines; HeLa, CESS (Epstein-Barr virus-transformed human B cell line), MT-1 (HTLV-I-infected human T cell line without viral protein synthesis), and MT-2 (HTLV-I-infected human T cell line producing viral proteins).
(9) In contrast to L2 and L3 in L1 the mid gut runs down in a straight line without any looping.
(10) In addition, KM231 could detect a small amount of the antigen ganglioside in human gastric normal and cancerous mucosa and in gastric cancer cell lines by HPTLC-immunostaining.
(11) Taken together these results are consistent with the view that primary CTL, as well as long term cloned CTL cell lines, exercise their cytolytic activity by means of perforin.
(12) It is my desperate hope that we close out of town.” In the book, God publishes his own 'It Getteth Better' video and clarifies his original writings on homosexuality: I remember dictating these lines to Moses; and afterward looking up to find him staring at me in wide-eyed astonishment, and saying, "Thou do knowest that when the Israelites read this, they're going to lose their fucking shit, right?"
(13) The aetiological factors concerned in the production of paraumbilical and epigastric hernias have been reviewed along structural--functional lines.
(14) The antiproliferative activity of IFN was studied using the parental L cell line, a tk- derivative, and a tk- (tk+) subline into which the tk gene of herpes simplex virus was introduced.
(15) A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness.
(16) "This was very strategic and it was in line of the ideology of the Bush administration which has been to put in place a free market and conservative agenda."
(17) Cell lines specific for class I or class II loci of the MHC produced interferon and colony-stimulating factors.
(18) Seven patients were treated with combination chemotherapy, consisting of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or MOPP (chloromethine, vincristine, procarbazine, prednisone), in some cases followed by non-cross-resistant second line chemotherapy, if no complete response was attained.
(19) Displacement of a colinear line over the same range without an offset evoked little, if any, response.
(20) N-Ethylmaleimide-sensitive 5'-nucleotide phosphodiesterase and alkaline phosphatase activities from other cell lines were also recovered in the cytosol.