(n.) Any animal, vegetable, or mineral substance used in the composition of medicines; any stuff used in dyeing or in chemical operations.
(n.) Any commodity that lies on hand, or is not salable; an article of slow sale, or in no demand.
(v. i.) To prescribe or administer drugs or medicines.
(v. t.) To affect or season with drugs or ingredients; esp., to stupefy by a narcotic drug. Also Fig.
(v. t.) To tincture with something offensive or injurious.
(v. t.) To dose to excess with, or as with, drugs.
Example Sentences:
(1) Previous use of the drug is found in more than 50 per cent of the patients, and it was often followed by a neglected side-effect.
(2) Disease stabilisation was associated with prolonged periods of comparatively high plasma levels of drug, which appeared to be determined primarily by reduced drug clearance.
(3) The significance of minor increases in the serum creatinine level must be recognized, so that modifications of drug therapy can be made and correction of possibly life-threatening electrolyte imbalances can be undertaken.
(4) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(5) Theophylline kinetics, as an in vivo probe for the potentially toxic cytochrome P-450I pathway of drug metabolism, were studied in 11 healthy volunteers and 11 patients with calcific chronic pancreatitis at Madras, South India.
(6) However, medicines have an important part to play, and it is now generally agreed that for the very poor populations medicines should be restricted to those on an 'essential drugs list' and should be made available as cheaply as possible.
(7) The ability of azelastine to influence antigen-induced contractile responses (Schultz-Dale phenomenon) in isolated tracheal segments of the guinea-pig was investigated and compared with selected antiallergic drugs and inhibitors of arachidonic acid metabolism.
(8) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(9) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(10) Some of those drugs are able to stimulate the macrophages, even in an aspecific way, via the gut associated lymphatic tissue (GALT), that is in connection with the bronchial associated lymphatic tissue (BALT).
(11) The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs.
(12) The results of the evaluation confirm that most problems seen by first level medical personnel in developing countries are simple, repetitive, and treatable at home or by a paramedical worker with a few safe, essential drugs, thus avoiding unnecessary visits to a doctor.
(13) Acquired drug resistance to INH, RMP, and EMB can be demonstrated in M. kansasii, and SMX in combination with other agents chosen on the basis of MIC determinations are effective in the treatment of disease caused by RMP-resistant M. kansasii.
(14) Further development of drug formulary concept was discussed, primarily for the drugs paid by the Health Insurance, as well as the unsatisfactory ADR reporting in Yugoslavia.
(15) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(16) The authors empirically studied the self-medication hypothesis of drug abuse by examining drug effects and motivation for drug use in 494 hospitalized drug abusers.
(17) Inadequate treatment, caused by a lack of drugs and poorly trained medical attendants, is also a major problem.
(18) To investigate the relationship between Helicobacter pylori infection and nonsteroidal anti-inflammatory drug (NSAID) intolerance and the effect of gold use on the seroprevalence of H. pylori.
(19) A remarkable deterioration of prognosis with increasing age rises the question whether treatment with cytotoxic drugs should be tried in patients more than 60 years old.
(20) It was concluded that metoclopramide and dexamethasone showed an excellent antiemetic effect on acute drug-induced emesis, as well as on delayed emesis, induced by cisplatin.
Narcosis
Definition:
(n.) Privation of sense or consciousness, due to a narcotic.
Example Sentences:
(1) In contrast, the same concentration of isopropanol produced narcosis in the dams, retarded body-weight gain and reduced the feed intake.
(2) The time of ethanol-induced narcosis and the extent of ethanol-induced hypothermia were not affected.
(3) The changes attributable to premedication and narcosis were characterized by a primary fibrinolysis which was accompanied by a slight hypercoagulability.
(4) If no progress can be achieved, narcosis mobilization and brisement modéré should be done.
(5) Monomodal neurons had more often simple RF and invariance of OT to narcosis.
(6) Narcosis (pentobarbital) inhibited markedly the resting and stimulated enzyme secretion.
(7) The indices of renal functionality are studied during the course of ether anesthesia in order to ascertain the behaviour of the kidney subjected to narcosis with this drug.
(8) In this particular case, the narcosis has permitted the uncovering of delusions and consequently the administration of the appropriate treatment.
(9) The concept of a critical-volume fraction of anesthetic being necessary for narcosis was discussed in most detail by Mullins.
(10) The antagonism of narcosis or sedation was evident against other barbiturates, diazepam, chlorpromazine, and reserpine, but not against morphine.
(11) Pressor responses were usually obtained in conscious cats, and also narcosis produced reversal effect on rare occasions.
(12) In addition, H2-receptor blocking agents such as cimetidine, ranitidine and famotidine clearly antagonized Hi-induced prolongation of thiopental narcosis, while pyrilamine and chlorpheniramine had no effect.
(13) For acute narcosis (50% mortality) the toxicant level in the hydrophobic (lipid) phase of an exposed organism is, as a first approximation, constant at approximately 50 mmol l-1 of lipid.
(14) In conclusion, these studies suggest that THF, like other commonly used organic solvents, causes narcosis in rats and mice.
(15) The arterial blood gases and pH remained at the predive control level in group 2 rats, whereas serum corticosterone concentration fell to 60% during compression (P less than 0.01), possibly due to N2 narcosis, but increased gradually toward 80% of C value during the pressure exposure.
(16) Nitrous oxide does not appear to benefit emotional or physiological adaptation to nitrogen narcosis associated with breathing hyperbaric air, and may even impair emotional adaptation, at least under these experimental conditions.
(17) Employment of this drug to prevent bronchospastic crises in 10 asthmatic patients subjected to narcosis is reported.
(18) Under nembutal narcosis on cats, intracellular electrophysiological studies have been made of common properties and differences in the neuronal organization of the nucleus reticularis tegmenti pontis and intrinsic pontine nuclei.
(19) The indications of the method include subdiaphragmatic surgery, interventions on more than one anatomical region, surgery in aging patients, patients with full stomach, and those with anaesthetic and surgical risk, as well as socioeconomic factors which may prevent application of a differentiated and safe narcosis.
(20) Opposing this, the application of neurotensin appears to potentiate ethanol narcosis.