(1) Previous use of the drug is found in more than 50 per cent of the patients, and it was often followed by a neglected side-effect.
(2) Disease stabilisation was associated with prolonged periods of comparatively high plasma levels of drug, which appeared to be determined primarily by reduced drug clearance.
(3) The significance of minor increases in the serum creatinine level must be recognized, so that modifications of drug therapy can be made and correction of possibly life-threatening electrolyte imbalances can be undertaken.
(4) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(5) Theophylline kinetics, as an in vivo probe for the potentially toxic cytochrome P-450I pathway of drug metabolism, were studied in 11 healthy volunteers and 11 patients with calcific chronic pancreatitis at Madras, South India.
(6) However, medicines have an important part to play, and it is now generally agreed that for the very poor populations medicines should be restricted to those on an 'essential drugs list' and should be made available as cheaply as possible.
(7) The ability of azelastine to influence antigen-induced contractile responses (Schultz-Dale phenomenon) in isolated tracheal segments of the guinea-pig was investigated and compared with selected antiallergic drugs and inhibitors of arachidonic acid metabolism.
(8) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(9) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(10) Some of those drugs are able to stimulate the macrophages, even in an aspecific way, via the gut associated lymphatic tissue (GALT), that is in connection with the bronchial associated lymphatic tissue (BALT).
(11) The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs.
(12) The results of the evaluation confirm that most problems seen by first level medical personnel in developing countries are simple, repetitive, and treatable at home or by a paramedical worker with a few safe, essential drugs, thus avoiding unnecessary visits to a doctor.
(13) Acquired drug resistance to INH, RMP, and EMB can be demonstrated in M. kansasii, and SMX in combination with other agents chosen on the basis of MIC determinations are effective in the treatment of disease caused by RMP-resistant M. kansasii.
(14) Further development of drug formulary concept was discussed, primarily for the drugs paid by the Health Insurance, as well as the unsatisfactory ADR reporting in Yugoslavia.
(15) Senator Bernie Sanders of Vermont, who is also seeking the Democratic presidential nomination, recently proposed a bill that would ease the financial burden of prescription drugs on elderly Americans by allowing Medicare, the national social health insurance program, to negotiate with the pharmaceutical companies to keep prices down.
(16) The authors empirically studied the self-medication hypothesis of drug abuse by examining drug effects and motivation for drug use in 494 hospitalized drug abusers.
(17) Inadequate treatment, caused by a lack of drugs and poorly trained medical attendants, is also a major problem.
(18) To investigate the relationship between Helicobacter pylori infection and nonsteroidal anti-inflammatory drug (NSAID) intolerance and the effect of gold use on the seroprevalence of H. pylori.
(19) A remarkable deterioration of prognosis with increasing age rises the question whether treatment with cytotoxic drugs should be tried in patients more than 60 years old.
(20) It was concluded that metoclopramide and dexamethasone showed an excellent antiemetic effect on acute drug-induced emesis, as well as on delayed emesis, induced by cisplatin.
Rugged
Definition:
(n.) Full of asperities on the surface; broken into sharp or irregular points, or otherwise uneven; not smooth; rough; as, a rugged mountain; a rugged road.
(n.) Not neat or regular; uneven.
(n.) Rough with bristles or hair; shaggy.
(n.) Harsh; hard; crabbed; austere; -- said of temper, character, and the like, or of persons.
(n.) Stormy; turbulent; tempestuous; rude.
(n.) Rough to the ear; harsh; grating; -- said of sound, style, and the like.
(n.) Sour; surly; frowning; wrinkled; -- said of looks, etc.
(n.) Violent; rude; boisterrous; -- said of conduct, manners, etc.
(n.) Vigorous; robust; hardy; -- said of health, physique, etc.
Example Sentences:
(1) The hosts had resisted through the early stages, emulating their rugged first-half displays against Manchester United and Arsenal here this season, and even mustered a flurry of half-chances just before the interval to offer a reminder they might glean greater reward thereafter.
(2) Steps wind down a rugged rock face to a bedroom, while light floods in from round skylights in the domed ceiling above.
(3) The Turner prize-winning artist has turned his sights on the survivalist and his exceptionally rugged version of masculinity, arguing that it isn’t fit for the 21st century.
(4) Many survivors use it to get the accommodations needed to stay in school, while others used it to hold their institutions accountable for sweeping sexual assault under the rug.” More than two dozen states are suing the Obama administration over its guidance on transgender students in an effort that is overwhelmingly led by Republican secretaries of state.
(5) As the president of Russia's Kalmykia republic from 1993 to 2010, Ilyumzhinov undoubtedly has close ties to the Kremlin, and a woven rug featuring Putin's face hangs in his office.
(6) Also, a wildfire in a rugged area near the Canadian border chased hundreds of people from their homes and burned 10 to 12 structures, and a blaze north-east of Colville scorched almost five square miles and forced evacuations at campgrounds in the area.
(7) Allergenic proteins were extracted from one silk batch that was imported to be used as filling material for bed mattresses and rugs.
(8) And reporting by the Observer reveals the extent to which al-Qaida has integrated itself with powerful tribes that control large swaths of Yemen's rugged east and parts of its south.
(9) FIVE MORE FRENCH COASTAL GEMS Marseille grotto Facebook Twitter Pinterest Photograph: Alamy A 40-minute walk from Marseille’s Luminy university campus, Calanque de Sugiton, the most picturesque of the city’s rugged, limestone coves has blue-green waters, twisted pine trees and a narrow island-rock to swim out to known as Le Torpilleur.
(10) Laminin and its E1-4 and E8 fragments are able to activate the ecto-5'-nucleotidase activity of both BCS-TC2 and Rugli cells.
(11) Pictures of the young Depardieu in a good light suggest a rugged, brooding, if not classically good-looking man with a squared chin and mop of blonde hair.
(12) In the presence of glucose oxidase and trien this polymer forms rugged, cross-linked, electroactive films on the surface of electrodes, thereby eliminating the requirement for a membrane for containing the enzyme and redox couple.
(13) The tone was set in the second minute when Ben Westwood, Warrington's notoriously rugged forward, left the Wigan stand-off Blake Green on the ground needing lengthy treatment.
(14) The simple design and rugged construction permit the incorporation of the apparatus into many manual or personal computer controlled oxygen consumption systems.
(15) Both offer lodges and campsites, but keep in mind that only a very small fraction of these remote and rugged parks are accessible by road.
(16) "When a similar report was released in 2009, the Administration largely swept it under the rug.
(17) La Posada has undergone a $12m renovation, transforming it into a magical place with handmade Mexican tin and tile mirrors, six-foot cast iron tubs, hand woven Zapotec rugs, and hand-painted furniture and tile murals.
(18) These assays have proven to be accurate, precise, reproducible, and rugged during clinical sample analyses.
(19) And cutting support now would take demand out of the economy, pull the rug from under the recovery, and delay our return to sustained growth.
(20) Chelsea had laboured at times without him in that first period, Begovic denying them reward from an urgent opening and Stoke rugged and organised until self-destructing with half-time in sight.