(n.) One backward in book learning; a child or other person dull or weak in intellect; a dullard; a dolt.
Example Sentences:
(1) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(2) Mutant dunce flies have elevated levels of cAMP and exhibit a number of defects including learning deficiencies and female sterility.
(3) These homologies, together with prior genetic and biochemical studies, provide unambiguous evidence that dunce+ codes for a phosphodiesterase.
(4) The recovery of clones from the differential screen demonstrates that in addition to altering normal behavior, fertility, and cAMP metabolism, dunce mutation confers an alteration in the level of expression of certain genes.
(5) The cDNA clone defines dunce exons which are separated by a large intron of 79 kb.
(6) We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster.
(7) It is basic maths – not so much the Wolf of Wall Street, more the Dunce of Downing Street."
(8) The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.
(9) In addition, the dunce+ gene product shares a seven-amino acid sequence with a regulatory subunit of cAMP-dependent protein kinase that is predicted to be part of the cAMP binding site.
(10) Not all are convinced that Pisa officials should don the dunce cap.
(11) We have isolated and sequenced cDNA clones representing portions of the polyadenylylated transcripts of the dunce+ gene.
(12) Winter Garden Theatre, New York, starts 9 November A Confederacy of Dunces John Kennedy Toole didn’t live long enough to see the publication of his celebrated comic novel, so he definitely isn’t around for the theatrical adaptation, which will premier at the Huntington with designs on a Broadway run.
(13) The molecular organization of the dunce gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1).
(14) Female columnists have not been kind to the group in retrospect; Caitlin Moran basically blamed "Girl Power" for the loss of interest in feminism, while Grace Dent went further by saying that "any student in 2012 who regurgitates this Spice Girls-helped-feminism baloney in a dissertation should have the whole thing shredded and be made to wear a dunce cone in graduation pics".
(15) Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles.
(16) The deduced amino acid sequences of part of this region were also homologous to the D. melanogaster dunce PDE and to PDEs from bovine and yeast.
(17) Two dunce mutants examined show aberrant RNA expression from this coding region, confirming that this region is the dunce gene.
(18) A probe representing the Drosophila dunce+ (dnc+) gene, the structural gene for a cAMP phosphodiesterase (PDEase), detects homologous sequences in many different organisms, including mouse, rat, and human.
(19) In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP.
(20) Coisogenic lines were constructed which varied at the dunce gene (dnc+ and dncM14 alleles) in order to test this hypothesis.
Fool
Definition:
(n.) A compound of gooseberries scalded and crushed, with cream; -- commonly called gooseberry fool.
(n.) One destitute of reason, or of the common powers of understanding; an idiot; a natural.
(n.) A person deficient in intellect; one who acts absurdly, or pursues a course contrary to the dictates of wisdom; one without judgment; a simpleton; a dolt.
(n.) One who acts contrary to moral and religious wisdom; a wicked person.
(n.) One who counterfeits folly; a professional jester or buffoon; a retainer formerly kept to make sport, dressed fantastically in motley, with ridiculous accouterments.
(v. i.) To play the fool; to trifle; to toy; to spend time in idle sport or mirth.
(v. t.) To infatuate; to make foolish.
(v. t.) To use as a fool; to deceive in a shameful or mortifying manner; to impose upon; to cheat by inspiring foolish confidence; as, to fool one out of his money.
Example Sentences:
(1) After trading mistakes, Wawrinka got lucky at 30-30, mishitting a service return and fooling Djokovic.
(2) How opiates became the love of my life | Alisha Choquette Read more The numbers are not specific to the type of drug used, but we’d be fools to think opiates don’t lead the list.
(3) Sage did not suffer fools gladly, and often the world seemed increasingly full of them.
(4) But it is difficult not to conclude that the survey, which ends on St Andrew’s day, 30 November, has been something of a fools errand for those loyal driveway-trampers.
(5) The idea that these problems exist on the other side of the world, and that we Australians can ignore them by sheltering comfortably in our own sequestered corner of the globe, is a fool’s delusion.” Brandis sought to reach out to Australian Muslims, saying the threat came “principally from a small number of people among us who try to justify criminal acts by perverting the meaning of Islam”.
(6) "So don't be fooled again: you cannot afford Labour.
(7) The Peppers like to be jerks (at Dingwalls Swan dedicated a song to “all you whiney Britishers who can suck my American cock”), but don’t let the surface attitude fool you.
(8) So it is only a fool, like me, who would walk nonchalantly around the headland during a high wind.
(9) A few months later, the certificate was discovered being used in Iran to fool people who were accessing Gmail into thinking that their connection was secure; in fact any suitably equipped hacker could have monitored their emails.
(10) It's Jane Austen all over again, and we've just fooled ourselves that the complicated financial system has changed a thing.
(11) No sufferer of fools, he also found it difficult to put up with what he felt to be the arrogance of some colleagues.
(12) An immensely cerebral man, who trained himself to need only six hours of sleep - believing that a woman should have seven and only a fool eight - Mishcon was not a man given to small talk, nor one who would tolerate prattle for the sake of it.
(13) Standing Rock protests: this is only the beginning Read more “When the Dakota Access Pipeline breaks (and we know that too many pipelines do), millions of people will have crude-oil-contaminated water … don’t let the automatic sink faucets in your homes fool you – that water comes from somewhere, and the second its source is contaminated, so is your bathtub, and your sink, and your drinking liquid.
(14) He has been declared "a Shakespearean fool, the only one who can say what others can't" and "an antidote to the proliferation of neo-Nazi movements which took hold of Hungary and Greece".
(15) It helps to make testing fun, capitalizes on the student's natural tendency to fool around, and teaches something in the process.
(16) 7.44pm BST The April Fools' Day jokes have slowed as people actually get back to work, so we're going to sign off.
(17) He said: "To people of a certain age, Stuart Hall will be known as the presenter of It's A Knockout, a good-natured TV programme in which members of the public cheerfully made fools of themselves on camera.
(18) Although his finance minister François Baroin pledged on Friday night that there would be no more "austerity measures", only a fool, or someone who expected to be out of office later this year, would promise otherwise.
(19) In other words, Mr Johnson is making a fool of himself and of Britain over issues that will have the deepest national repercussions.
(20) Cue the day’s first SPR (silent printer rage): another four minutes eaten up by a printer refusing to be fooled by the off-on tactic.