(n.) One backward in book learning; a child or other person dull or weak in intellect; a dullard; a dolt.
Example Sentences:
(1) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(2) Mutant dunce flies have elevated levels of cAMP and exhibit a number of defects including learning deficiencies and female sterility.
(3) These homologies, together with prior genetic and biochemical studies, provide unambiguous evidence that dunce+ codes for a phosphodiesterase.
(4) The recovery of clones from the differential screen demonstrates that in addition to altering normal behavior, fertility, and cAMP metabolism, dunce mutation confers an alteration in the level of expression of certain genes.
(5) The cDNA clone defines dunce exons which are separated by a large intron of 79 kb.
(6) We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster.
(7) It is basic maths – not so much the Wolf of Wall Street, more the Dunce of Downing Street."
(8) The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.
(9) In addition, the dunce+ gene product shares a seven-amino acid sequence with a regulatory subunit of cAMP-dependent protein kinase that is predicted to be part of the cAMP binding site.
(10) Not all are convinced that Pisa officials should don the dunce cap.
(11) We have isolated and sequenced cDNA clones representing portions of the polyadenylylated transcripts of the dunce+ gene.
(12) Winter Garden Theatre, New York, starts 9 November A Confederacy of Dunces John Kennedy Toole didn’t live long enough to see the publication of his celebrated comic novel, so he definitely isn’t around for the theatrical adaptation, which will premier at the Huntington with designs on a Broadway run.
(13) The molecular organization of the dunce gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1).
(14) Female columnists have not been kind to the group in retrospect; Caitlin Moran basically blamed "Girl Power" for the loss of interest in feminism, while Grace Dent went further by saying that "any student in 2012 who regurgitates this Spice Girls-helped-feminism baloney in a dissertation should have the whole thing shredded and be made to wear a dunce cone in graduation pics".
(15) Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles.
(16) The deduced amino acid sequences of part of this region were also homologous to the D. melanogaster dunce PDE and to PDEs from bovine and yeast.
(17) Two dunce mutants examined show aberrant RNA expression from this coding region, confirming that this region is the dunce gene.
(18) A probe representing the Drosophila dunce+ (dnc+) gene, the structural gene for a cAMP phosphodiesterase (PDEase), detects homologous sequences in many different organisms, including mouse, rat, and human.
(19) In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP.
(20) Coisogenic lines were constructed which varied at the dunce gene (dnc+ and dncM14 alleles) in order to test this hypothesis.
Gaby
Definition:
(n.) A simpleton; a dunce; a lout.
Example Sentences:
(1) Along with a lengthy list of cameos, Girls actor Gaby Hoffmann and Party Down star Martin Starr appear as former Neptune High classmates new to the Veronica Mars universe.
(2) There’s a real potential to make a difference to people’s lives Gaby Stewart There is no doubt that working in prisons, for professionals from any field, is challenging.
(3) | Gaby Hinsliff, Gary Younge, Polly Toynbee and Giles Fraser Read more It should go without saying that these are the people the Labour party was founded to represent .
(4) Gaby Hinsliff Everyone wants their own Sturgeon now Where do we find a Nicola Sturgeon?
(5) Gaby Bertin, the press secretary, will also grow in influence, as will the cabinet secretary Sir Jeremy Heywood.
(6) "If a mainstream politician had described the holocaust as the 'holocon' or listed the Jews in the media – from Michael Grade to Gaby Roslin – they would be hammered," he says.
(7) A simple free-kick from Gabi about 35 yards out is sent into the box and all Raúl García, who is located near the back post, has to do is jump and head the ball past Abbiati.
(8) Not only did the success of Girls propel Dunham to the status of poster-girl for a generation of floundering millennials, but watching back it’s easy to spot plenty of other now-familiar faces: Adam Driver, Gaby Hoffman, Desiree Akhavan and Jenny Slate to name a few.
(9) Tambor’s children are self-involved, sexually confused and in the middle of various life crises, with Girls star Gaby Hoffman particularly impressive as listless youngest daughter Ali.
(10) The substitute Correa finished off a lofted pass from the captain, Gabi, leaving Deportivo in 13th place in the table and still without a league win in 2016.
(11) Journalist Gaby Hinsliff, who decided to resign from her job as political editor of the Observer two years ago, wrote movingly about the difficulties she'd experienced trying to balance a round-the-clock career with family life.
(12) Awkward | Gaby Hinsliff Read more The “work penalty” – as some have begun calling the cuts to tax credits – will not just hammer poorer voters, who disproportionately tend to either vote Labour or not vote at all.
(13) 10.06pm BST ET 18 min: Gabi foolishly gifts Real possession as he trots upfield aimlessly.
(14) I once associated the actor Gaby Hoffmann with cuteness thanks to her youthful appearance in films such as Sleepless in Seattle and Field of Dreams.
(15) Although I don’t remember his birth, I remember Dad taking me to our local Chinese restaurant for a celebratory meal: a tradition we honoured in some form or another when each of my other siblings – Lizzie, Gaby and Josh – was born.
(16) Then Gaby Sanchez took off for no reason whatsoever and also got gunned down.
(17) This year, they are novelist Susan Hill, writer and journalist Matthew d'Ancona, political diarist Chris Mullin and Gaby Wood, head of books at the Telegraph .
(18) Photograph: Photoshot Gaby Hoffmann Former child star of Sleepless In Seattle and Uncle Buck is back as Adam's nightmarish sister in season three of Girls .
(19) But if Simeone’s half time change– Jesús Gámez for Gabi – seemed to suggest resistance 10-men Atlético emerged stronger and applied pressure once more.
(20) Gabi, the Atlético midfielder, will also be banned because of a yellow card but it is clearly not ideal for Mourinho that he now has to rely on Schwarzer for the remainder of the season.