(n.) One backward in book learning; a child or other person dull or weak in intellect; a dullard; a dolt.
Example Sentences:
(1) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(2) Mutant dunce flies have elevated levels of cAMP and exhibit a number of defects including learning deficiencies and female sterility.
(3) These homologies, together with prior genetic and biochemical studies, provide unambiguous evidence that dunce+ codes for a phosphodiesterase.
(4) The recovery of clones from the differential screen demonstrates that in addition to altering normal behavior, fertility, and cAMP metabolism, dunce mutation confers an alteration in the level of expression of certain genes.
(5) The cDNA clone defines dunce exons which are separated by a large intron of 79 kb.
(6) We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster.
(7) It is basic maths – not so much the Wolf of Wall Street, more the Dunce of Downing Street."
(8) The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.
(9) In addition, the dunce+ gene product shares a seven-amino acid sequence with a regulatory subunit of cAMP-dependent protein kinase that is predicted to be part of the cAMP binding site.
(10) Not all are convinced that Pisa officials should don the dunce cap.
(11) We have isolated and sequenced cDNA clones representing portions of the polyadenylylated transcripts of the dunce+ gene.
(12) Winter Garden Theatre, New York, starts 9 November A Confederacy of Dunces John Kennedy Toole didn’t live long enough to see the publication of his celebrated comic novel, so he definitely isn’t around for the theatrical adaptation, which will premier at the Huntington with designs on a Broadway run.
(13) The molecular organization of the dunce gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1).
(14) Female columnists have not been kind to the group in retrospect; Caitlin Moran basically blamed "Girl Power" for the loss of interest in feminism, while Grace Dent went further by saying that "any student in 2012 who regurgitates this Spice Girls-helped-feminism baloney in a dissertation should have the whole thing shredded and be made to wear a dunce cone in graduation pics".
(15) Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles.
(16) The deduced amino acid sequences of part of this region were also homologous to the D. melanogaster dunce PDE and to PDEs from bovine and yeast.
(17) Two dunce mutants examined show aberrant RNA expression from this coding region, confirming that this region is the dunce gene.
(18) A probe representing the Drosophila dunce+ (dnc+) gene, the structural gene for a cAMP phosphodiesterase (PDEase), detects homologous sequences in many different organisms, including mouse, rat, and human.
(19) In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP.
(20) Coisogenic lines were constructed which varied at the dunce gene (dnc+ and dncM14 alleles) in order to test this hypothesis.
Ounce
Definition:
(n.) A weight, the sixteenth part of a pound avoirdupois, and containing 437/ grains.
(n.) The twelfth part of a troy pound.
(n.) Fig.: A small portion; a bit.
(n.) A feline quadruped (Felis irbis, / uncia) resembling the leopard in size, and somewhat in color, but it has longer and thicker fur, which forms a short mane on the back. The ounce is pale yellowish gray, with irregular dark spots on the neck and limbs, and dark rings on the body. It inhabits the lofty mountain ranges of Asia. Called also once.
Example Sentences:
(1) If the police stop me they will have no right to ask me where I got my stuff provided it's not more than an ounce.
(2) The spot price of gold fell by $34 an ounce to $1,442.
(3) HDL2 levels were only significantly different between nondrinkers and those who consumed more than 3 ounces per week.
(4) The mothers of 127 adolescents living in Muscatine, Iowa were asked at the time of a clinic examination to recall their child's birthweight in pounds and ounces.
(5) It was in 1999 that the then chancellor, Gordon Brown, dumped half of Britain's gold reserves at an average selling price of $248 an ounce.
(6) The 12-hour ordeal for Stephanie – who did not wish to speak on the record or use her real name for fear of jeopardizing her job prospects – took place after police found one ounce of marijuana in her car.
(7) Calcium tablets, like almost all drugs, should be taken with 8 ounces of water or other liquid.
(8) Life-style characteristics associated with HDL-C in women were exogenous hormone use, average number of cigarettes smoked per day, average ounces of alcohol consumed per week, body mass index, and use of beta-blockers.
(9) The hypothesis that a cholesterol challenge to the breast fed infant would enable the adult to more efficiently metabolize the sterol does not seem to be supported by available evidence, primarily, because the cholesterol content of human milks varies so markedly; 26 to 52 mg per 8 ounces.
(10) The metaphor has now moved back closer to its slave plantation origins, imagining modern masses sapped of every ounce of living labour.
(11) The other airport boss sympathises: "Is it them being greedy, or airlines wanting every ounce of capacity when they can?
(12) Forty male undergraduates over 21 years of age were provoked following their ingestion of either 1.5 ounces (.045 1) or .5 ounces (.015 1) of 100 proof bourbon or vodka per 40 (18 kg) of body weight.
(13) Investors bet on gold as a safe haven driving prices to a record $1,663.40 an ounce.
(14) Average daily consumption of alcohol declined significantly from 1.4 ounces in 1982 to 1.2 ounces in 1985, but the patterns of use remained relatively constant.
(15) Risk for anatomic abnormalities in the offspring was clearly defined among the 5.6% of infants whose mothers drank more than three ounces of absolute alcohol, that is, more than six drinks, per day.
(16) After that grandstanding, no one about whom there was an ounce of homosexual suspicion wanted to be seen with me, much less date me.
(17) While the terms "light" and "heavy" are relative, forces ranging from 6 to 24 ounces were variants great enough in the areas treated to have elicited movement if movement were possible.
(18) Spraying of malathion at a dosage of 4.5 fluid ounces per acre reduced populations of adult Anopheles albimanus to less than 1% of prespray levels and interrupted epidemic transmission of P. falciparum malaria.
(19) Worldwide, weak property prices and volatile stock markets have sent investors hurrying to buy gold as a safe haven, pushing gold prices to a record $1,895 an ounce on the London PM fix on 5 September 2011.
(20) Compared to the control periods, the mean maximal ischemic ST-segment depression after angina was not changed after Fresca but was increased after 2 ounces of ethanol (P less than 0.01) and after 5 ounces of ethanol (P less than 0.001).