(n.) One backward in book learning; a child or other person dull or weak in intellect; a dullard; a dolt.
Example Sentences:
(1) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(2) Mutant dunce flies have elevated levels of cAMP and exhibit a number of defects including learning deficiencies and female sterility.
(3) These homologies, together with prior genetic and biochemical studies, provide unambiguous evidence that dunce+ codes for a phosphodiesterase.
(4) The recovery of clones from the differential screen demonstrates that in addition to altering normal behavior, fertility, and cAMP metabolism, dunce mutation confers an alteration in the level of expression of certain genes.
(5) The cDNA clone defines dunce exons which are separated by a large intron of 79 kb.
(6) We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster.
(7) It is basic maths – not so much the Wolf of Wall Street, more the Dunce of Downing Street."
(8) The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.
(9) In addition, the dunce+ gene product shares a seven-amino acid sequence with a regulatory subunit of cAMP-dependent protein kinase that is predicted to be part of the cAMP binding site.
(10) Not all are convinced that Pisa officials should don the dunce cap.
(11) We have isolated and sequenced cDNA clones representing portions of the polyadenylylated transcripts of the dunce+ gene.
(12) Winter Garden Theatre, New York, starts 9 November A Confederacy of Dunces John Kennedy Toole didn’t live long enough to see the publication of his celebrated comic novel, so he definitely isn’t around for the theatrical adaptation, which will premier at the Huntington with designs on a Broadway run.
(13) The molecular organization of the dunce gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1).
(14) Female columnists have not been kind to the group in retrospect; Caitlin Moran basically blamed "Girl Power" for the loss of interest in feminism, while Grace Dent went further by saying that "any student in 2012 who regurgitates this Spice Girls-helped-feminism baloney in a dissertation should have the whole thing shredded and be made to wear a dunce cone in graduation pics".
(15) Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles.
(16) The deduced amino acid sequences of part of this region were also homologous to the D. melanogaster dunce PDE and to PDEs from bovine and yeast.
(17) Two dunce mutants examined show aberrant RNA expression from this coding region, confirming that this region is the dunce gene.
(18) A probe representing the Drosophila dunce+ (dnc+) gene, the structural gene for a cAMP phosphodiesterase (PDEase), detects homologous sequences in many different organisms, including mouse, rat, and human.
(19) In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP.
(20) Coisogenic lines were constructed which varied at the dunce gene (dnc+ and dncM14 alleles) in order to test this hypothesis.
Pinhead
Definition:
Example Sentences:
(1) McDowell, a film-maker in his own right, collaborated with Kuchar on several movies, as an actor in Siamese Twin Pinheads (1972), The Sunshine Sisters (1972) and The Devil's Cleavage (1975), a 130-minute recreation of 1940s and 50s black-and-white melodramas.
(2) In laboratory feeding tests, family groups of wild mice maintained in pens and conditioned to feeding on plain foods were offered flupropadine at either 0.10%, 0.15%, 0.18% or 0.20% in pinhead oatmeal bait.
(3) The palatability of glycerine and six oils, each included at 5% in pinhead oatmeal, was compared in a similar manner.The most favoured food was found to be whole canary seed (Phalaris canariensis).
(4) In six workers, unroofed vesicles, pinhead areas of postinflammatory hyperpigmentation, and excoriation marks were noted at these sites.
(5) FIPTs, on ophthalmoscopy, usually are pinpoint to pinhead size, round or oval, dull white in color, and situated in deeper layers of the retina and beside the major retinal arteries and their main branches.
(6) It was here that in 2002 Markram began accumulating data on a section of the rat neocortex no larger than a pinhead.
(7) Both poisons were applied in pinhead oatmeal bait containing also 5% corn oil, after pre-baiting.
(8) WBA 8119 at 0-002%, 0-005% and 0-01% in pinhead oatmeal bait gave complete kills of mice in 'no-choice' feeding tests carried out in cages and small pens.
(9) An objective examination of the patient revealed the presence of multiple follicular comedones, black in colour, the size of a pinhead, and of yellowish follicular papulas, 2-5 mm in size, of solid consistency, on the top of which is a formation similar to comedone.
(10) For subjects considered by each reader to present predominantly p type opacities, increasing opacity profusion was exclusively and significantly associated with an increase in the number of pinhead fibrotic nodules.
(11) Neuropathological findings were as usual, with additional unusual features: pinhead-size areas of acute myelin-abbau products, involvement of grey in addition to white matter, and upon ultrastructure, the new finding of intra-oligodendroglial fingerprint bodies, both in neuronal satellite and in white matter oligoglia, but not in astrocytes, ganglion cells, or pericytes.
(12) The characteristic appearance of "pinhead" outpouching from the lumen of the esophagus is seen with contrast esophagram.
(13) It was Douglas, now an emeritus professor at the Swiss Federal Institute of Technology in Zurich, who first fired Markram's enthusiasm for lab work and, with his exceptionally steady hands – useful when stitching together neurons smaller than a pinhead, Markram was soon enjoying a meteoric rise.
(14) They are firm deposits of monosodium urate in crystal form, which develop from pinhead-size to egg-size in the subcutaneous tissue.
(15) Idiopathic calcinosis of the scrotum usually develops in the form of scrotal calcified nodules varying in number from 1 to over 100 and from pinhead to walnut in size.
(16) Medieval schoolmen sharpened their brains by counting angels on pinheads.
(17) Pinhead oatmeal and wheat were also comparatively well accepted.
(18) "The fungus is very, very small, like pinheads, on the leaf stalks.
(19) In four pen trials, family groups of laboratory-reared wild mice were conditioned to feeding on plain foods and then offered flocoumafen at 0.005% in pinhead oatmeal bait.
(20) The relation between the profusion and predominant type of small rounded opacities on chest radiographs taken within four years of death and the postmortem counts of dust lesions in four classes (macules, "pinhead" fibrotic nodules, nodules 1-3 mm, and nodules greater than 3-9 mm in diameter) has been examined for 71 coalworkers without progressive massive fibrosis.