(n.) One backward in book learning; a child or other person dull or weak in intellect; a dullard; a dolt.
Example Sentences:
(1) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(2) Mutant dunce flies have elevated levels of cAMP and exhibit a number of defects including learning deficiencies and female sterility.
(3) These homologies, together with prior genetic and biochemical studies, provide unambiguous evidence that dunce+ codes for a phosphodiesterase.
(4) The recovery of clones from the differential screen demonstrates that in addition to altering normal behavior, fertility, and cAMP metabolism, dunce mutation confers an alteration in the level of expression of certain genes.
(5) The cDNA clone defines dunce exons which are separated by a large intron of 79 kb.
(6) We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster.
(7) It is basic maths – not so much the Wolf of Wall Street, more the Dunce of Downing Street."
(8) The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.
(9) In addition, the dunce+ gene product shares a seven-amino acid sequence with a regulatory subunit of cAMP-dependent protein kinase that is predicted to be part of the cAMP binding site.
(10) Not all are convinced that Pisa officials should don the dunce cap.
(11) We have isolated and sequenced cDNA clones representing portions of the polyadenylylated transcripts of the dunce+ gene.
(12) Winter Garden Theatre, New York, starts 9 November A Confederacy of Dunces John Kennedy Toole didn’t live long enough to see the publication of his celebrated comic novel, so he definitely isn’t around for the theatrical adaptation, which will premier at the Huntington with designs on a Broadway run.
(13) The molecular organization of the dunce gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1).
(14) Female columnists have not been kind to the group in retrospect; Caitlin Moran basically blamed "Girl Power" for the loss of interest in feminism, while Grace Dent went further by saying that "any student in 2012 who regurgitates this Spice Girls-helped-feminism baloney in a dissertation should have the whole thing shredded and be made to wear a dunce cone in graduation pics".
(15) Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles.
(16) The deduced amino acid sequences of part of this region were also homologous to the D. melanogaster dunce PDE and to PDEs from bovine and yeast.
(17) Two dunce mutants examined show aberrant RNA expression from this coding region, confirming that this region is the dunce gene.
(18) A probe representing the Drosophila dunce+ (dnc+) gene, the structural gene for a cAMP phosphodiesterase (PDEase), detects homologous sequences in many different organisms, including mouse, rat, and human.
(19) In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP.
(20) Coisogenic lines were constructed which varied at the dunce gene (dnc+ and dncM14 alleles) in order to test this hypothesis.
Silly
Definition:
(n.) Happy; fortunate; blessed.
(n.) Harmless; innocent; inoffensive.
(n.) Weak; helpless; frail.
(n.) Rustic; plain; simple; humble.
(n.) Weak in intellect; destitute of ordinary strength of mind; foolish; witless; simple; as, a silly woman.
(n.) Proceeding from want of understanding or common judgment; characterized by weakness or folly; unwise; absurd; stupid; as, silly conduct; a silly question.
Example Sentences:
(1) We just hope that … maybe she’s gone to see her friend, talk some sense into her,” Renu said, adding that Shamima “knew that it was a silly thing to do” and that she did not know why her friend had done it.
(2) And Myers is cautioned after a silly block 3.21am GMT 54 mins Besler with a long-throw for SKC but it's cleared.
(3) As if to prove her silly dilettantism, when a journalist asked Dasha about her favourite artists, she replied, "I'm, like, really bad at remembering names."
(4) Some of them, pulled together for the manifesto, are silly, or doomed, or simply there for shock value - information points in the form of holograms of Dixon of Dock Green, the legalisation of soft drugs, official brothels opposite Westminster, complete with division bells.
(5) I am of a similar vintage and, like many friends and fans of the series, bemoan the fact that we are generally treated by society as silly, weak, daft, soppy, prejudiced (even bigoted), risk-averse and wary of new situations.
(6) I had more fun with Matt Winning , delivering a silly set on the Free Fringe imagining himself the son of Robert Mugabe.
(7) Facebook Twitter Pinterest In an essay for the Hollywood Reporter, Camille Paglia writes that Swift promotes a ‘silly, regressive public image’.
(8) His selection on Twitter, he added, was “all in no particular order, off the top of my head, and the most incomplete of lists”, put together in response to Talese’s “silliness”.
(9) As soon as they saw how serious it was, they switched from being my silly, fun friends into being the most reliable and amazing people.
(10) They were all young, and it was a party house, devoted to games of hide and seek, music, silly practical jokes and food fights in the drawing room.
(11) As a result, one or two wrote some rather silly things in their reports,” Wilshaw said.
(12) ‘Silly things said by a silly man’ To be honest I really don’t care what BoJo says.
(13) People usually don't make silly, careless mistakes when they're motivated and working in a positive environment.
(14) Watching “our lads” pretending to mouth questionable lyrics about God giving the Queen near-immortal life, and her being the victor when she’s not really of fighting age, is silly.
(15) Imagine my relief this week then, when I found out that I can now let go of all my silly gay politics.
(16) We have referees who are unfamiliar with that silly "Goaltender Interference" technicality.
(17) The syndrome he described--a psychosis of early onset with a deteriorating course characterized by a "silly" affect, behavioral peculiarities, and formal thought disorder--not only adumbrated Kraepelin's generic category of dementia praecox but quite specifically defined the later subtype of hebephrenic, or disorganized, schizophrenia as well.
(18) "But they're so silly that I must say I never found them intimidating."
(19) Just as certain songs become inextricably associated in our minds with certain eras (before the invention of iPods, that is, after which everyone could walk around every day with all the songs in the world on shuffle), so too do silly trends.
(20) In 2014, she began working as a writer at Late Night with Seth Meyers; her first standup spot on that show began with a joke that typified both her silliness and confidence.