(n.) One backward in book learning; a child or other person dull or weak in intellect; a dullard; a dolt.
Example Sentences:
(1) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(2) Mutant dunce flies have elevated levels of cAMP and exhibit a number of defects including learning deficiencies and female sterility.
(3) These homologies, together with prior genetic and biochemical studies, provide unambiguous evidence that dunce+ codes for a phosphodiesterase.
(4) The recovery of clones from the differential screen demonstrates that in addition to altering normal behavior, fertility, and cAMP metabolism, dunce mutation confers an alteration in the level of expression of certain genes.
(5) The cDNA clone defines dunce exons which are separated by a large intron of 79 kb.
(6) We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster.
(7) It is basic maths – not so much the Wolf of Wall Street, more the Dunce of Downing Street."
(8) The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.
(9) In addition, the dunce+ gene product shares a seven-amino acid sequence with a regulatory subunit of cAMP-dependent protein kinase that is predicted to be part of the cAMP binding site.
(10) Not all are convinced that Pisa officials should don the dunce cap.
(11) We have isolated and sequenced cDNA clones representing portions of the polyadenylylated transcripts of the dunce+ gene.
(12) Winter Garden Theatre, New York, starts 9 November A Confederacy of Dunces John Kennedy Toole didn’t live long enough to see the publication of his celebrated comic novel, so he definitely isn’t around for the theatrical adaptation, which will premier at the Huntington with designs on a Broadway run.
(13) The molecular organization of the dunce gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1).
(14) Female columnists have not been kind to the group in retrospect; Caitlin Moran basically blamed "Girl Power" for the loss of interest in feminism, while Grace Dent went further by saying that "any student in 2012 who regurgitates this Spice Girls-helped-feminism baloney in a dissertation should have the whole thing shredded and be made to wear a dunce cone in graduation pics".
(15) Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles.
(16) The deduced amino acid sequences of part of this region were also homologous to the D. melanogaster dunce PDE and to PDEs from bovine and yeast.
(17) Two dunce mutants examined show aberrant RNA expression from this coding region, confirming that this region is the dunce gene.
(18) A probe representing the Drosophila dunce+ (dnc+) gene, the structural gene for a cAMP phosphodiesterase (PDEase), detects homologous sequences in many different organisms, including mouse, rat, and human.
(19) In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP.
(20) Coisogenic lines were constructed which varied at the dunce gene (dnc+ and dncM14 alleles) in order to test this hypothesis.
Stupid
Definition:
(a.) Very dull; insensible; senseless; wanting in understanding; heavy; sluggish; in a state of stupor; -- said of persons.
(a.) Resulting from, or evincing, stupidity; formed without skill or genius; dull; heavy; -- said of things.
Example Sentences:
(1) A series of hierarchical multiple regressions revealed the effects of Surgency, Agreeableness, Conscientiousness, Emotional Stability, and Intellect on evoking upset in spouses through condescension (e.g., treating spouse as stupid or inferior), possessiveness (demanding too much time and attention), abuse (slapping spouse), unfaithfulness (having sex with others), inconsiderateness (leaving toilet seat up), moodiness (crying a lot), alcohol abuse (drinking too much alcohol), emotional constriction (hiding emotions to act tough), and self-centeredness (acting selfishly).
(2) In 1999, Kamprad admitted his past involvement with Nazism in a book about his life and asked for forgiveness for his "stupidity."
(3) Would I be stupid not to wait another six months or so, to get a 90% mortgage given the cons of Help to Buy?
(4) The lucky thing is, says Susan Calman , that although she is "an eternal worrier, occasionally I do something stupid."
(5) "The whole thing was stupid, Donald called him at once to discuss it, he had such a go at him, I mean, fuck, it's a shame we didn't record it, he fucked him up good, had such a proper fucking go at him."
(6) @HunterFelt October 28, 2013 Ali Mason (@alimason) Reassuring to see the #redsox aren't the only ones who can find stupid ways to lose.
(7) But like so many of his colleagues in the Trump administration , Spicer has shown us how unconsciousness and stupidity can, however paradoxically, assume a Machiavellian function – how a flagrant example of gross insensitivity and flat-out odiousness can serve as yet another useful and convenient distraction.
(8) He must have had PR training – didn’t it stretch to not saying stupid stuff?
(9) I’d love to say it’s this big, machiavellian plan, but the main thing to blame is human stupidity,” says Phillip Adcock, author of Shoppology: The Science of Supermarket Shopping.
(10) Barack Obama today phoned the white policeman he said had "acted stupidly" in arresting a black Harvard professor in his own home and invited the officer to visit the White House as the president attempted to defuse a growing race row over the incident.
(11) It’s just one stupid statement after another.” Large crowds of protesters gathered outside the Gyumri base, where Permyakov is now being held, demanding that he be handed over to Armenian law-enforcement to ensure he is prosecuted locally.
(12) And then her drug use got harder, and more desperate, and then it wasn't funny any more; and then, when she was trying to clean up, she was dead, gone to join "the stupid club", as Kurt Cobain's mother described all the rock stars who end up dead at 27.
(13) You've got to have more than that, you've got to make them better players, because players aren't stupid.
(14) Ukip is exploiting the stupidity of ignorant anti-immigrant voters for electoral gain.
(15) I still have a few pints of gin and tonic before I go onstage but nothing stupid."
(16) More here: UK regulator urges banks to speed up swaps mis-selling compensation 8.40am GMT More reaction to the decision to send riot police to evict people from the offices of Greece's former state broadcaster this morning , starting with journalist Nick Malkoutzis: Nick Malkoutzis (@NickMalkoutzis) 5 mths after flicking switch on public broadcaster ERT, gov't tries to settle issue by sending riot police to remove remaining staff #Greece November 7, 2013 Nick Malkoutzis (@NickMalkoutzis) While #ERT will be off air for good after police intervention, the stain of how its closure has been handled won't wash away easily #Greece November 7, 2013 Lady Mondegreen (@amaenad) Like a mean stupid dog appeasing a cruel master, the Greek government wants to lay ERT's limp body at the troika's feet.
(17) The boss of a successful US hedge fund has quit the industry with an extraordinary farewell letter dismissing his rivals as over-privileged "idiots" and thanking "stupid" traders for making him rich.
(18) I think that's a challenge all of us go through, whether it's a parent knowing they are going to have to die and leave their kids behind or it's a young person saying I haven't left my mark yet, I lived for no reason – but that's a stupid way of thinking because as Hazel says in the book there will come a day when Mozart isn't remembered so don't worry about it!
(19) The president should have directed the Justice Department to stop taking stupid points and petty appeals.” One reason the Justice Department pursued the habeas cases so hard was its client: the Pentagon.
(20) More from Behind the joke • James Acaster: 'Normal people perv solo' • Phil Wang: impossibly wise or offensively stupid • Holly Walsh: 'I build my comedy block-by-block like Lego'