(n.) One backward in book learning; a child or other person dull or weak in intellect; a dullard; a dolt.
Example Sentences:
(1) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(2) Mutant dunce flies have elevated levels of cAMP and exhibit a number of defects including learning deficiencies and female sterility.
(3) These homologies, together with prior genetic and biochemical studies, provide unambiguous evidence that dunce+ codes for a phosphodiesterase.
(4) The recovery of clones from the differential screen demonstrates that in addition to altering normal behavior, fertility, and cAMP metabolism, dunce mutation confers an alteration in the level of expression of certain genes.
(5) The cDNA clone defines dunce exons which are separated by a large intron of 79 kb.
(6) We have isolated several genes expressed at abnormal levels in the memory mutant, dunce (dnc), of Drosophila melanogaster.
(7) It is basic maths – not so much the Wolf of Wall Street, more the Dunce of Downing Street."
(8) The nucleotide sequence of this clone led to the identification of a dunce exon included in at least one transcript so far uncharacterized.
(9) In addition, the dunce+ gene product shares a seven-amino acid sequence with a regulatory subunit of cAMP-dependent protein kinase that is predicted to be part of the cAMP binding site.
(10) Not all are convinced that Pisa officials should don the dunce cap.
(11) We have isolated and sequenced cDNA clones representing portions of the polyadenylylated transcripts of the dunce+ gene.
(12) Winter Garden Theatre, New York, starts 9 November A Confederacy of Dunces John Kennedy Toole didn’t live long enough to see the publication of his celebrated comic novel, so he definitely isn’t around for the theatrical adaptation, which will premier at the Huntington with designs on a Broadway run.
(13) The molecular organization of the dunce gene of Drosophila melanogaster has proved to be particularly complex, with two divergently transcribed genes, Sgs-4 and Pig-1, nested within its 79 kb intron (1).
(14) Female columnists have not been kind to the group in retrospect; Caitlin Moran basically blamed "Girl Power" for the loss of interest in feminism, while Grace Dent went further by saying that "any student in 2012 who regurgitates this Spice Girls-helped-feminism baloney in a dissertation should have the whole thing shredded and be made to wear a dunce cone in graduation pics".
(15) Selection of mutations that suppress dunce sterility has led to the isolation of two rutabaga alleles.
(16) The deduced amino acid sequences of part of this region were also homologous to the D. melanogaster dunce PDE and to PDEs from bovine and yeast.
(17) Two dunce mutants examined show aberrant RNA expression from this coding region, confirming that this region is the dunce gene.
(18) A probe representing the Drosophila dunce+ (dnc+) gene, the structural gene for a cAMP phosphodiesterase (PDEase), detects homologous sequences in many different organisms, including mouse, rat, and human.
(19) In both dunce and rutabaga larvae, voltage-clamp analysis of neuromuscular transmission revealed impaired synaptic facilitation and post-tetanic potentiation as well as abnormal responses to direct application of dibutyryl cAMP.
(20) Coisogenic lines were constructed which varied at the dunce gene (dnc+ and dncM14 alleles) in order to test this hypothesis.
Weak
Definition:
(v. i.) Wanting physical strength.
(v. i.) Deficient in strength of body; feeble; infirm; sickly; debilitated; enfeebled; exhausted.
(v. i.) Not able to sustain a great weight, pressure, or strain; as, a weak timber; a weak rope.
(v. i.) Not firmly united or adhesive; easily broken or separated into pieces; not compact; as, a weak ship.
(v. i.) Not stiff; pliant; frail; soft; as, the weak stalk of a plant.
(v. i.) Not able to resist external force or onset; easily subdued or overcome; as, a weak barrier; as, a weak fortress.
(v. i.) Lacking force of utterance or sound; not sonorous; low; small; feeble; faint.
(v. i.) Not thoroughly or abundantly impregnated with the usual or required ingredients, or with stimulating and nourishing substances; of less than the usual strength; as, weak tea, broth, or liquor; a weak decoction or solution; a weak dose of medicine.
(v. i.) Lacking ability for an appropriate function or office; as, weak eyes; a weak stomach; a weak magistrate; a weak regiment, or army.
(v. i.) Not possessing or manifesting intellectual, logical, moral, or political strength, vigor, etc.
(v. i.) Feeble of mind; wanting discernment; lacking vigor; spiritless; as, a weak king or magistrate.
(v. i.) Resulting from, or indicating, lack of judgment, discernment, or firmness; unwise; hence, foolish.
(v. i.) Not having full confidence or conviction; not decided or confirmed; vacillating; wavering.
(v. i.) Not able to withstand temptation, urgency, persuasion, etc.; easily impressed, moved, or overcome; accessible; vulnerable; as, weak resolutions; weak virtue.
(v. i.) Wanting in power to influence or bind; as, weak ties; a weak sense of honor of duty.
(v. i.) Not having power to convince; not supported by force of reason or truth; unsustained; as, a weak argument or case.
(v. i.) Wanting in point or vigor of expression; as, a weak sentence; a weak style.
(v. i.) Not prevalent or effective, or not felt to be prevalent; not potent; feeble.
(v. i.) Lacking in elements of political strength; not wielding or having authority or energy; deficient in the resources that are essential to a ruler or nation; as, a weak monarch; a weak government or state.
(v. i.) Tending towards lower prices; as, a weak market.
(v. i.) Pertaining to, or designating, a verb which forms its preterit (imperfect) and past participle by adding to the present the suffix -ed, -d, or the variant form -t; as in the verbs abash, abashed; abate, abated; deny, denied; feel, felt. See Strong, 19 (a).
(v. i.) Pertaining to, or designating, a noun in Anglo-Saxon, etc., the stem of which ends in -n. See Strong, 19 (b).
(a.) To make or become weak; to weaken.
Example Sentences:
(1) There was a weak relation between AER and both systolic and diastolic blood pressures.
(2) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
(3) Consensual but rationally weak criteria devised to extract inferences of causality from such results confirm the generic inadequacy of epidemiology in this area, and are unable to provide definitive scientific support to the perceived mandate for public health action.
(4) The strengths and weaknesses of each technique are described in this article.
(5) In group V, five cases of Taenia saginata parasitosis were studied showing a weak positive reading.
(6) Although the longest period required for resolving weakness was three days, the MRI, the CT and the electroencephalogram revealed no significant abnormality.
(7) Her muscle weakness and hyperCKemia markedly improved by corticosteroid therapy, suggesting that the diagnosis was compatible with polymyositis (PM).
(8) It was concluded that Ta acts as a weak zeitgeber in laboratory rats and has greater effects on males compared to females.
(9) And adding to this toxic mix, was the fear that the hung parliament would lead to a weak government.
(10) Sensory loss, motor weakness, paraesthesia and a new pain were found as complications in 12, 7, 4 and 6 patients, respectively.
(11) Here's Dominic's full story: US unemployment rate drops to lowest level in six years as 288,000 jobs added Michael McKee (@mckonomy) BNP economists say jobless rate would have been 6.8% if not for drop in participation rate May 2, 2014 2.20pm BST ING's Rob Carnell is also struck by the "extraordinary weakness" of US wage growth .
(12) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(13) The weakness was treated by intensive physical rehabilitation with complete and sustained recovery in all cases.
(14) It also showed weak inhibition of the solid type of Ehrlich carcinoma and prolonged the survival period of mice inoculated with L-1210 cells.
(15) Exposure to whole cigarette smoke from reference cigarettes results in the prompt (peak activity is 6 hrs), but fairly weak (similar to 2 fold), induction of murine pulmonary microsomal monooxygenase activity.
(16) Though the concept of phase, known also as focus, is a very helpful notion, its empirical foundation is yet very weak.
(17) DL 071 IT, a new potent non-selective beta-adrenergic blocking drug with intrinsic sympathomimetic activity and weak membrane stabilizing activity, was evaluated alone and in comparison with oxprenolol, in six volunteers, at rest and during an exercise test.
(18) A variety of weak acids at and below their pK(a) are potent inhibitors of transport in Penicillium chrysogenum.
(19) It added that the crisis had highlighted significant weaknesses in financial regulation, with further measures needed to strengthen supervision.
(20) The radioprotective action in E. coli ATCC 9637 of ascorbate added to media containing the weak sensitizer, tetracycline (effect described by Pittillo and Lucas (1967)), was found to be dependent on the presence of metal catalysts of the autoxidation of ascorbate.