(1) Validation studies, to show that the method is precise, accurate and rectilinear, have been carried out on four linctus formulations and two pastille formulations.
(2) A selective high-performance liquid chromatographic procedure has been developed for the determination of the major Ipecacuanha alkaloids, emetine and cephaeline, in a number of linctus and pastille preparations.
(3) Where another writer might have dished out such experiences with a moralising linctus or a fake spirit of adventure, Lewis gave them to us page after page, year after year, as the most delicious of unaging wines.
(4) A rapid and simple method for the assay of pholcodine in various syrup and linctus formulations, based on color reaction with p-dimethylaminobenzaldehyde, is suggested.
(5) Bronchodilator treatment was being taken by 12% of the patients with symptoms, regular cough linctus by 10%, and regular antibiotics by 5%.
(6) Sample preparation is simple, involving either straight dilution for linctus formulations or simple dissolutions for pastilles.
(7) In a double-blind randomized study 60 patients with either irritative cough due to seasonal respiratory disorders or chronic cough of any etiology were treated with either butamirate citrate linctus (Sinecod, Zyma) or with clobutinol syrup (Silomat, Boehringer, Ingelheim) for a period of 5 days at a dose regimen of 3 tablespoons daily.
(8) Lotussin and linctus diphenhydramine were compared for efficacy and patient preference in fifty patients suffering from post-infective cough.
(9) In all three subjects 100 mg. of phenylpropanolamine taken orally caused a more pronounced rise of systolic pressure and a rise of diastolic pressure.In contrast, 50 mg. of phenylpropanolamine orally caused a rapid and potentially dangerous rise of blood pressure in a subject taking the monamine oxidase inhibitor tranylcypromine, and a similar acute rise of blood pressure occurred in this subject when given a proprietary cough linctus containing the same dose of phenylpropanolamine.
(10) We describe a case of accidental ingestion of podophyllin, mistaken for cough linctus, and its resultant toxicity.
(11) The proprietary formulations chosen for study were Phensedyl linctus, Avil tablets and Ponderax tablets.