(v. t.) The thin cutting side of the blade of an instrument; as, the edge of an ax, knife, sword, or scythe. Hence, figuratively, that which cuts as an edge does, or wounds deeply, etc.
(v. t.) Any sharp terminating border; a margin; a brink; extreme verge; as, the edge of a table, a precipice.
(v. t.) Sharpness; readiness of fitness to cut; keenness; intenseness of desire.
(v. t.) The border or part adjacent to the line of division; the beginning or early part; as, in the edge of evening.
(v. t.) To furnish with an edge as a tool or weapon; to sharpen.
(v. t.) To shape or dress the edge of, as with a tool.
(v. t.) To furnish with a fringe or border; as, to edge a dress; to edge a garden with box.
(v. t.) To make sharp or keen, figuratively; to incite; to exasperate; to goad; to urge or egg on.
(v. t.) To move by little and little or cautiously, as by pressing forward edgewise; as, edging their chairs forwards.
(v. i.) To move sideways; to move gradually; as, edge along this way.
(v. i.) To sail close to the wind.
Example Sentences:
(1) Brown's model, which goes far further than those from any other senior Labour figure, and the modest new income tax powers for Holyrood devised when he was prime minister, edge the party much closer to the quasi-federal plans championed by the Liberal Democrats.
(2) Everyone is expecting them to win and I think that’s a double-edged sword.
(3) In fact, the lowest-rated game of last year's World Series between the Giants and the Tigers edged out the opening round of the draft by only 2.4 million viewers.
(4) In one case MRI showed a false image of tear of the supra spinatus m. on its anterior edge.
(5) Flexion of the knee beyond 40 degrees progressively diminished viability of the edges of the wound, particularly the lateral edge.
(6) Fibrinogen was scattered in the intercellular spaces, and located in the inner layer or edges of the thickened intima of the bifurcation with increasing plaque formation.
(7) After 1 day in vitro the explants were partly encircled by epithelium which had proliferated from the cut edges of the explant and from rete ridges near the cut edge (epiboly).
(8) This kind of distribution of microfilaments was always associated with resorption lacunae, and F-actin, vinculin, and talin zones correspond roughly to the edge of lacunae.
(9) Mario Balotelli’s life on the edge leaves him asking: why not me any more?
(10) Shenhua Watermark Coal, a subsidiary of the Chinese state-owned Shenhua Group, is waiting for final approval from Hunt for a $1.2bn open-cut coalmine on the edge of the plains, a little more than three kilometres from Hamparsum’s property.
(11) Three disks of different sizes (10, 25, and 45 mm in diameter) were attached to the edge of the baresthesiometer, and pressures of 1, 3 and 5 kg were applied to the 10 mm disk, and 1, 3, 5, and 7 kg to the other disks.
(12) The expansion comes hot on the heels of another year of stellar growth in which Primark edged closer to overtaking high street stalwart M&S in sales and profits.
(13) Under the electron microscope, slices appeared vacuolated near the cut surfaces, but well preserved internally (greater than 40 micron from the edge).
(14) Following orthodontic treatment the canine's incisal edge occlusion demonstrates the tip and torque present in the appliance that was used.
(15) Attenuation compensation causes more noise to appear in the center than the edge for both modes and an average increase in uncertainty of 30%.
(16) Perisic darts in from the edge of the penalty area to get on the end of it and thumps a meaty header wide.
(17) The transversalis fascia of the floor of the femoral canal turns down to form the medial wall of the venous compartment of the femoral sheath, and has the support of the curved edge of the lacunar ligament which effectively bars the femoral canal from entering the thigh.
(18) Trout fishing is excellent in both, and after they fall over the edge of the Piedmont Plateau to the Atlantic Coastal Plain, the lower stretches of both waterways boil into class-2 and -3 whitewater for kayakers and canoeists.
(19) Oxytocin-like immunoreactive neurons were observed to lie within 77 nm of the edge of the lumen of capillary blood vessels.
(20) A formal notion of relatability is defined, specifying which physically given edges leading into discontinuities can be connected to others by interpolated edges.
Engrailed
Definition:
(imp. & p. p.) of Engrail
(a.) Indented with small concave curves, as the edge of a bordure, bend, or the like.
Example Sentences:
(1) An ectopic expression assay in Drosophila embryos was used to investigate the roles of pair-rule segmentation genes in the spatial regulation of the segment-polarity gene, engrailed (en).
(2) Engrailed has been suggested to play an important role during development by controlling position-specific characteristics in the CNS of the early embryo.
(3) The engrailed gene is required during embryogenesis of Drosophila melanogaster for normal segmental development and for differentiation of posterior compartments.
(4) Genetic analysis in Drosophila has shown that engrailed (en) plays an important role in segmentation and neurogenesis.
(5) The first pattern of expression is in alternating segments followed by expression in every segment, suggesting that engrailed may be responding to pair-rule segmentation gene products.
(6) By contrast, the homeo box within the engrailed gene diverges substantially and, unlike the other homeo boxes, is interrupted by an intervening sequence.
(7) These results indicate that 1) Engrailed-2 expression is suppressed in the most ventral neural tube owing to induction of the floor plate by the notochord, and 2) that the presence of an underlying notochord is not required for correct rostrocaudal expression, suggesting that multiple pathways act in the patterning of the rudiment of the central nervous system.
(8) The crystal structure of a complex containing the engrailed homeodomain and a duplex DNA site has been determined at 2.8 A resolution and refined to a crystallographic R factor of 24.4%.
(9) This early requirement for engrailed does not appear to be a maternal function, and only genetically engrailed embryos displayed these precellular phenotypes.
(10) No other transcribed regions were found up to 16 kb downstream and 48 kb upstream of the engrailed transcription unit, the portion of the genome to which engrailed mutations have been mapped.
(11) Comparison of amino acid sequences between the entire Xenopus En-2 and the Drosophila engrailed proteins confirms conservation of sequences inside as well as proximal to the homeobox and reveals a region of similarity towards the N terminus.
(12) The Drosophila engrailed gene product (En) is a homeodomain-containing protein that contributes to segmental patterning.
(13) These results are discussed in the context of an autoregulatory model for engrailed regulation.
(14) hh expression in epidermal cells is confined to the posterior compartments and coincides precisely with that of engrailed (en).
(15) An enzyme system that accurately initiates transcription of the engrailed gene has been prepared from Drosophila embryos.
(16) We have examples of patches of hairy cells (where we monitor the effect on fushi tarazu (ftz) expression), even-skipped (monitoring ftz) and ftz (monitoring engrailed and Ultrabithorax).
(17) By examining embryonic expression of the mouse engrailed (En) genes, from 8.0 to 9.5 days postcoitum, we demonstrate that Wnt-1 primarily regulates midbrain development.
(18) This gene, which encodes a transmembrane protein, is initially expressed in a generalized way at blastoderm, but later stops being transcribed in cells expressing the engrailed gene, and even later in cells in the middle of the parasegment.
(19) Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.
(20) It appears to control morphogenesis by regulating the expression of the segmentation gene engrailed (en), and by autoregulating its own expression (M. Frasch and M.L., in preparation).