(1) This suggests that there was a deterioration of the vasoconstrictor response and indicated a possible effect of heat at the receptor or effector level.
(2) Three effector: target ratios (6.2:1, 25:1, and 50:1) were studied in quadruplicate using 3, 4 and 5-h incubations.
(3) The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally.
(4) The presence of a previously unreported dipeptide transport mechanism within blood leukocytes and the selective enrichment of the granule enzyme, DPPI, within cytotoxic effector cells of lymphoid or myeloid lineage appear to afford a unique mechanism for the targeting of immunotherapeutic reagents composed of simple dipeptide esters or amides.
(5) The isolated LGL were highly cytotoxic against YAC-1 lymphoma cells and this cytolytic activity was blocked by treatment of the effector cells with an antibody against natural killer cells (anti-asialo GM1).
(6) Interestingly, different mechanisms of nucleated and non-nucleated TC directed lysis by CD4+ effectors were implied by distinct patterns of sensitivity to cholera toxin (CT) and cyclosporin A (CsA).
(7) These killer cells could lyse a wide range of syngeneic and allogeneic lymphoid tumour cell lines in vitro, and it was found that cell suspensions from nude mice were always significantly more active than those from normal mice, and that the most active effector population was a polymorph-enriched peritoneal-exudate cell suspension.
(8) We speculate that intestinal injury may also induce or perpetuate arthritis by systemic distribution of inflammatory mediators produced by intestinal immune effector cells.
(9) Effector cells capable of mediating cytotoxicity in each assay were defined by testing the cytotoxic function of lymphocyte subpopulations isolated from two representative patients with each disease using techniques of immunoabsorbent affinity chromatography and Fc receptor binding to antigen-antibody complexes.
(10) Thus, monocytes may play a dual role, not only as effector cells, but also as cells that collaborate with T cells after OKT3 MoAb stimulation so as to produce PCA.
(11) Furthermore, effector TH cells within the two compartments exert differential effector activities: splenic effector TH cells induce B cells to both proliferation and maturation, while thymic effector TH cells are defective in activating B-cell maturation.
(12) Our results suggest that NCAM, in the presence of other AM, may have a supportive role in adhesion of leukaemic targets to LAK effectors.
(13) The cytolytic activity of peritoneal SEA reactive effector cells was confined to the TCR alpha beta+ CD4- CD8+ CD45RC- cell population.
(14) FBP was bound with greater frequency and intensity to 3-day oil-elicited peritoneal macrophages which are responsive to migration inhibition by FBP and migration inhibitory factor (MIF) than to resident or 7-day inflammatory macrophages which are unresponsive to activation by the same effectors.
(15) Pyocyanine did not interfere with interleukin 2 synthesis, nor did it affect the lytic stage of cytotoxic effector T cells.
(16) Such data show that effector cells which kill antibody-coated target cells may be of T cell nature.
(17) The immune system has evolved to protect an organism from the pathogens that invade it but the effector mechanisms involved in mediating this protection are potentially lethal to the host itself.
(18) Chimeric oligodeoxynucleotides, comprised of internal phosphodiester and terminal methylphosphonodiester sections, possess many beneficial characteristics as antisense effectors.
(19) The development of T cells from stem (progenitor) cells to effector cells results from a two-wave process of proliferation and differentiation.
(20) Because previous work has shown that radioisotope release from parasites may be nonspecific, separate experiments were performed to determine the cytotoxicity of LAK cells against antibody-coated trophozoites by using ethidium bromide-acridine orange staining to assess effector cell damage.
Nerve
Definition:
(n.) One of the whitish and elastic bundles of fibers, with the accompanying tissues, which transmit nervous impulses between nerve centers and various parts of the animal body.
(n.) A sinew or a tendon.
(n.) Physical force or steadiness; muscular power and control; constitutional vigor.
(n.) Steadiness and firmness of mind; self-command in personal danger, or under suffering; unshaken courage and endurance; coolness; pluck; resolution.
(n.) Audacity; assurance.
(n.) One of the principal fibrovascular bundles or ribs of a leaf, especially when these extend straight from the base or the midrib of the leaf.
(n.) One of the nervures, or veins, in the wings of insects.
(v. t.) To give strength or vigor to; to supply with force; as, fear nerved his arm.
Example Sentences:
(1) Such a signal must be due to a small ferromagnetic crystal formed when the nerve is subjected to pressure, such as that due to mechanical injury.
(2) They are going to all destinations.” Supplies are running thin and aftershocks have strained nerves in the city.
(3) Elements in the skin therefore seemed to enhance nerve regeneration and function.
(4) The possibility that the ventral nerve photoreceptor cells serve a neurosecretory function in the adult Limulus is discussed.
(5) Following central retinal artery ligation, infarction of the retinal ganglion cells was reflected by a 97 per cent reduction in the radioactively labeled protein within the optic nerve.
(6) During the performance of propulsive waves of the oesophagus the implanted vagus nerve caused clonic to tetanic contractions of the sternohyoid muscle, thus proving the oesophagomotor genesis of the reinnervating nerve fibres.
(7) The oral nerve endings of the palate, the buccal mucosa and the periodontal ligament of the cat canine were characterized by the presence of a cellular envelope which is the final form of the Henle sheath.
(8) Sixteen patients were operated on for lumbar pain and pain radiating into the sciatic nerve distribution.
(9) The dependence of fluorescence polarization of stained nerve fibres on the angle between the fibre axis and electrical vector of exciting light (azimuth characteristics) has been considered.
(10) No monosynaptic connexions were found between anterodorsal and posteroventral muscles except between the muscles innervated by the peroneal and the tibial nerve.
(11) Histological studies of nerves 2 years following irradiation demonstrated loss of axons and myelin, with a corresponding increase in endoneurial, perineurial, and epineurial connective tissue.
(12) The ATP content of the cholinergic electromotor nerves of Torpedo marmorata has been measured.
(13) Plasma NPY correlated better with plasma norepinephrine than with epinephrine, indicating its origin from sympathetic nerve terminals.
(14) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(15) Standard nerve conduction techniques using constant measured distances were applied to evaluate the median, ulnar and radial nerves.
(16) An experimental autoimmune model of nerve growth factor (NGF) deprivation has been used to assess the role of NGF in the development of various cell types in the nervous system.
(17) Noradrenaline (NA) was released from sympathetic nerve endings in the tissue by electrical stimulation of the mesenteric nerves or by the indirect sympathomimetic agent tyramine.
(18) However, none of the nerve terminals making synaptic contacts with glomus cells exhibited SP-like immunoreactivity.
(19) The number of axons displaying peptide-like immunoreactivity within the optic nerve, retinal or cerebral to the crush, and within the optic chiasm gradually decreased after 2-3 months.
(20) Somatostatin-like immunoreactivity has been found to occur in nerve terminals and fibres of the normal human skin using immunohistochemistry.