(1) This suggests that there was a deterioration of the vasoconstrictor response and indicated a possible effect of heat at the receptor or effector level.
(2) Three effector: target ratios (6.2:1, 25:1, and 50:1) were studied in quadruplicate using 3, 4 and 5-h incubations.
(3) The results support the notion that mediator lymphocytes circulate in tumor immunized rats in a noncytotoxic state, specifically recognize tumor cells at a challenge site, and mediate induction of effector cells locally.
(4) The presence of a previously unreported dipeptide transport mechanism within blood leukocytes and the selective enrichment of the granule enzyme, DPPI, within cytotoxic effector cells of lymphoid or myeloid lineage appear to afford a unique mechanism for the targeting of immunotherapeutic reagents composed of simple dipeptide esters or amides.
(5) The isolated LGL were highly cytotoxic against YAC-1 lymphoma cells and this cytolytic activity was blocked by treatment of the effector cells with an antibody against natural killer cells (anti-asialo GM1).
(6) Interestingly, different mechanisms of nucleated and non-nucleated TC directed lysis by CD4+ effectors were implied by distinct patterns of sensitivity to cholera toxin (CT) and cyclosporin A (CsA).
(7) These killer cells could lyse a wide range of syngeneic and allogeneic lymphoid tumour cell lines in vitro, and it was found that cell suspensions from nude mice were always significantly more active than those from normal mice, and that the most active effector population was a polymorph-enriched peritoneal-exudate cell suspension.
(8) We speculate that intestinal injury may also induce or perpetuate arthritis by systemic distribution of inflammatory mediators produced by intestinal immune effector cells.
(9) Effector cells capable of mediating cytotoxicity in each assay were defined by testing the cytotoxic function of lymphocyte subpopulations isolated from two representative patients with each disease using techniques of immunoabsorbent affinity chromatography and Fc receptor binding to antigen-antibody complexes.
(10) Thus, monocytes may play a dual role, not only as effector cells, but also as cells that collaborate with T cells after OKT3 MoAb stimulation so as to produce PCA.
(11) Furthermore, effector TH cells within the two compartments exert differential effector activities: splenic effector TH cells induce B cells to both proliferation and maturation, while thymic effector TH cells are defective in activating B-cell maturation.
(12) Our results suggest that NCAM, in the presence of other AM, may have a supportive role in adhesion of leukaemic targets to LAK effectors.
(13) The cytolytic activity of peritoneal SEA reactive effector cells was confined to the TCR alpha beta+ CD4- CD8+ CD45RC- cell population.
(14) FBP was bound with greater frequency and intensity to 3-day oil-elicited peritoneal macrophages which are responsive to migration inhibition by FBP and migration inhibitory factor (MIF) than to resident or 7-day inflammatory macrophages which are unresponsive to activation by the same effectors.
(15) Pyocyanine did not interfere with interleukin 2 synthesis, nor did it affect the lytic stage of cytotoxic effector T cells.
(16) Such data show that effector cells which kill antibody-coated target cells may be of T cell nature.
(17) The immune system has evolved to protect an organism from the pathogens that invade it but the effector mechanisms involved in mediating this protection are potentially lethal to the host itself.
(18) Chimeric oligodeoxynucleotides, comprised of internal phosphodiester and terminal methylphosphonodiester sections, possess many beneficial characteristics as antisense effectors.
(19) The development of T cells from stem (progenitor) cells to effector cells results from a two-wave process of proliferation and differentiation.
(20) Because previous work has shown that radioisotope release from parasites may be nonspecific, separate experiments were performed to determine the cytotoxicity of LAK cells against antibody-coated trophozoites by using ethidium bromide-acridine orange staining to assess effector cell damage.
Stimulus
Definition:
(v. t.) A goad; hence, something that rouses the mind or spirits; an incentive; as, the hope of gain is a powerful stimulus to labor and action.
(v. t.) That which excites or produces a temporary increase of vital action, either in the whole organism or in any of its parts; especially (Physiol.), any substance or agent capable of evoking the activity of a nerve or irritable muscle, or capable of producing an impression upon a sensory organ or more particularly upon its specific end organ.
Example Sentences:
(1) In the absence of atrial dilatation there was minimal stimulus for ANF secretion.
(2) At the same time the duodenum can be isolated from the stomach and maintained under constant stimulus by a continual infusion at regulated pressure, volume and temperature into the distal cannula.
(3) With glucose and protein as intraduodenal stimulus (no pancreatin added), the plasma amino acids rose significantly less (by approximately 50% of the control experiment) and the increment in insulin (but not C-peptide) concentrations was significantly reduced by loxiglumide.
(4) Since intracellular Ca2+ seems to play a role in stimulus-secretion coupling and ion movements, several aspects of Ca2+ homeostasis have been investigated in CF.
(5) Three coyotes were operantly conditioned to depress one of two foot treadles, left or right, depending on the condition of the stimulus light.
(6) Clinical measurements of the loudness discomfort level (LDL) are generally performed while the subject listens to a particular stimulus presented from an audiometer through headphones (AUD-HP).
(7) NE differentially affected responses to stimulus movement in the preferred and non-preferred direction in one-third of these neurons, such that directional selectivity was increased.
(8) II, the visual and auditory stimuli were exposed conversely over the habituation- (either stimulus) and the test-periods (both stimuli).
(9) The marine vibrio alone is a powerful stimulus to mucus secretion but lethal for the host.
(10) Taken together with our previous studies showing that MDMA substitutes for the phenylisopropylamine stimulant (+)amphetamine, but that neither MDE nor N-OH MDA substitute for (+)amphetamine or for the phenylisopropylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), the present results [i.e., MDMA-stimulus generalization to MDE, N-OH MDA, but not to (+)amphetamine] suggest that 1) MDMA produces effects other than those that may be considered amphetamine-like, and 2) MDE and N-OH MDA are MDMA-like agents with even less of an amphetamine-like component of action than MDMA itself.
(11) Changes in pain tolerance after administration of differently labelled placebos were studied by measuring the reaction time after a cold stimulus.
(12) 27% of the neurons revealed high sensitivity to the temperature stimulus with coefficient Q10 from 2.4 to 30; 6% of the neurons reacted by the on-response type; 5% of the neurons changed their activity and preserved the new level.
(13) Isolated outer hair cells from the organ of Corti of the guinea pig have been shown to change length in response to a mechanical stimulus in the form of a tone burst at a fixed frequency of 200 Hz (Canlon et al., 1988).
(14) Adhesion and O2- production were also found to be differentially affected by the NADPH oxidase inhibitor diphenylene iodonium, the sulfhydryl reagent N-ethylmaleimide and the A2 agonist adenosine, indicating that these neutrophil responses have various transductional pathways that also depend on the type of stimulus.
(15) The following results were obtained: 1) In normal subjects, the changes in ABR waveforms according to the changes of the rise-time, interstimulus interval and frequency of the stimulus were mainly attributed to component wave C. 2) In patients with central disorders, component wave C were initially affected.
(16) Following each stimulus, the subject had to press a button for RT and then report the digit perceived.
(17) Subjects with high ocular-dominance scores (right- or left-dominant subjects) showed for the green stimulus asymmetric behavior, while subjects with low ocular-dominance scores showed a tendency toward symmetry in perception.
(18) Prior to each long-term intake test, rats received a 1 min, 1 ml intraoral infusion of the same chemical stimulus.
(19) In positive patterning, elemental stimuli, A and B, were presented without an unconditioned stimulus while their compound, AB, was paired with electric shock.
(20) In a recent study, Orr and Lanzetta (1984) showed that the excitatory properties of fear facial expressions previously described (Lanzetta & Orr, 1981; Orr & Lanzetta, 1980) do not depend on associative mechanisms; even in the absence of reinforcement, fear faces intensify the emotional reaction to a previously conditioned stimulus and disrupt extinction of an acquired fear response.