(1) It was concluded that metoclopramide and dexamethasone showed an excellent antiemetic effect on acute drug-induced emesis, as well as on delayed emesis, induced by cisplatin.
(2) The neuroleptic agents haloperidol, fluphenazine, domperidone, sulpiride and tiapride also antagonized emesis induced by cisplatin but only a proportion of the animals were completely protected and diazepam and prednisolone only reduced the intensity of the response.
(3) Despite excellent control of acute-stage emesis, some patients are still bothered by delayed emesis occurring more than 24 hours after cisplatin administration.
(4) Nine patients suffered emesis in spite of prophylactic therapy and were classified as grade 3.
(5) The efficacy of ipecac syrup in the induction of emesis and safety of its administration was studied in 105 poison-exposed infants 6 through 11 months of age (study subjects) and compared prospectively with 302 poison-exposed infants and children 12 through 35 months of age who served as age controls.
(6) We have compared the ability of drugs to induce chewing and retching or emesis in squirrel monkeys; such studies are not possible in rodents, which do not vomit.
(7) One of these agents, batanopride, produced no severe toxicity at doses that prevented emesis due to chemotherapy in early Phase I trials.
(8) One hundred ten pediatric patients, ages 8 months to 14 yr, admitted for outpatient strabismus surgery were enrolled in a randomized, double-blinded study to compare droperidol and metoclopramide to placebo for the prevention of postoperative emesis.
(9) The aftereffects of home-induced emesis with ipecac syrup were determined by telephone interviews of callers to a poison center.
(10) The treatment given followed the purpose to eliminate the toxic: emesis, gastric washing and in cases of respiratory depression, naloxone was given.
(11) Clinical evidence of pain on injection, myoclonic muscle activity, apnea, nausea, and emesis were documented.
(12) Postoperative emesis, the most common reason for unscheduled admissions, occurred in 23.4% of patients.
(13) Emesis has long been thought to be organized by a 'vomiting centre'; the possibility that this vomiting centre could be the parvocellular reticular formation is reviewed, as is the concept that the 'centre' is larger than an anatomically defined single group of cells.
(14) The 24-h pH monitoring data were within normal ranges in 26 infants (20 controls, 2 babies with emesis, and 4 with RD).
(15) Both findings demonstrate that bismuth subsalicylate can provide antiemetic action and that the decreases in the occurrence of emesis in humans and dogs parallels the decrease in nausea found in humans and the nausea suspected to occur prior to emesis in dogs.
(16) As ICS205930, at high doses, is reported to be a 5-HT4 receptor antagonist it appears likely that activation of 5HT4-receptors contributes to emesis induced by zacopride.
(17) Only in recent years has serious attention been given to the control of chemotherapy-induced emesis (CIE) which is to the patient a most obnoxious side-effect.
(18) Two other sets of experiments suggest that dopaminergic mechanisms play a minor role in radiation-induced emesis in the ferret.
(19) There was no evidence of emesis during the experiments or of overt changes in the appearance of the oral cavity, heart, liver, spleen, kidney, proventriculus, gizzard, and intestines of a random sample of birds killed by carbon dioxide asphyxiation and necropsied.
(20) YM-08050 was more potent than either HPD or CPZ in inhibitory effects on a variety of behaviors such as apomorphine-induced stereotypes behavior and emesis, methamphetamine-induced stereotyped behavior, conditioned avoidance response and open field behavior.
Ipecac
Definition:
(n.) An abbreviation of Ipecacuanha, and in more frequent use.
Example Sentences:
(1) The efficacy of ipecac syrup in the induction of emesis and safety of its administration was studied in 105 poison-exposed infants 6 through 11 months of age (study subjects) and compared prospectively with 302 poison-exposed infants and children 12 through 35 months of age who served as age controls.
(2) The aftereffects of home-induced emesis with ipecac syrup were determined by telephone interviews of callers to a poison center.
(3) Recent literature suggests using initial charcoal therapy instead of ipecac as a first-line antidotal agent for many acute poisonings.
(4) Griseofulvin exerts a direct though partial influence on the mitotic apparatus, which entails "pluripolar anaphasis"; on the other hand Ipecac alkaloïds act indirectly and produce "floating poles anaphases".
(5) Eight and two tenths percent were referred to a health care facility, 2.9% obtained ipecac from a neighbor, 2.3% went to an emergency room prior to calling the poison center, and 3% obtained ipecac from other sources.
(6) Successful emesis was defined as emesis within 30 minutes after ipecac administration, while failure was defined as emesis occurring more than 30 minutes after administration.
(7) The time of onset of ipecac-induced emesis is not significantly influenced by the temperature of concurrently administered fluid.
(8) Two cases (120 mg and 300 mg) received ipecac at home and were followed by telephone with 1.4 and 24 hr callbacks.
(9) Progressive myopathy developed in two women who consumed ipecac syrup containing emetine hydrochloride to induce vomiting as part of their anorexia nervosa.
(10) Patients presenting on even-numbered days had no gastric emptying procedures performed, and they were compared to patients presenting on odd-numbered days who received either syrup of ipecac or gastric lavage.
(11) The symptom presentation and management problems in this case are discussed to alert clinicians involved in consultation about ipecac abuse.
(12) A study was conducted in ten human volunteers to determine if activated charcoal prevents the emetic effect of syrup of ipecac when a temporal separation exists between administration of the two substances.
(13) Ipecac toxicity should be considered in children with unexplained colitis and vomiting.
(14) Data from 100 patients, where 15 ml of syrup of ipecac was administered, revealed an average time for emesis to occur of 25.82 minutes.
(15) The rates at which 15- and 30-mL doses of syrup of ipecac induced emesis within 30 minutes were evaluated in pediatric patients treated for accidental poisoning.
(16) In the ipecac group the mean latency period before onset of vomiting was 11.6 minutes (range 4 to 26 min) and in the apomorphine group, 5.3 minutes (range 2 to 13 min) (P less than .01).
(17) Retail pharmacists should recognize their inadequate knowledge of Ipecac instructions.
(18) Ipecac syrup, administered to 11 patients, uniformly failed to expel the battery.
(19) However, several toxicities have been reported with the use of the fluid extract of ipecac.
(20) Poison education efforts should be targeted to populations with low ipecac availability and low utilization of the poison center.