(n.) The extreme or last point or part of any material thing considered lengthwise (the extremity of breadth being side); hence, extremity, in general; the concluding part; termination; close; limit; as, the end of a field, line, pole, road; the end of a year, of a discourse; put an end to pain; -- opposed to beginning, when used of anything having a first part.
(n.) Point beyond which no procession can be made; conclusion; issue; result, whether successful or otherwise; conclusive event; consequence.
(n.) Termination of being; death; destruction; extermination; also, cause of death or destruction.
(n.) The object aimed at in any effort considered as the close and effect of exertion; ppurpose; intention; aim; as, to labor for private or public ends.
(n.) That which is left; a remnant; a fragment; a scrap; as, odds and ends.
(n.) One of the yarns of the worsted warp in a Brussels carpet.
(v. t.) To bring to an end or conclusion; to finish; to close; to terminate; as, to end a speech.
(v. t.) To form or be at the end of; as, the letter k ends the word back.
(v. t.) To destroy; to put to death.
(v. i.) To come to the ultimate point; to be finished; to come to a close; to cease; to terminate; as, a voyage ends; life ends; winter ends.
Example Sentences:
(1) These included bringing in the A* grade, reducing the number of modules from six to four, and a greater attempt to assess the whole course at the end.
(2) The oral nerve endings of the palate, the buccal mucosa and the periodontal ligament of the cat canine were characterized by the presence of a cellular envelope which is the final form of the Henle sheath.
(3) A full-length cDNA encoding porcine heart aconitase was derived from lambda gt10 recombinant clones and by amplification of the 5' end of the mRNA.
(4) The present findings indicate that the deafferented [or isolated] hypothalamus remains neuronally isolated from the environment if the operation is carried out later than the end of the first week of life.
(5) In patients with coronary artery disease, electrocardiographic signs of left atrial enlargement (LAE-negative P wave deflection greater than or equal to 1 mm2 in lead V1) are associated with increased left ventricular end diastolic pressure (LVEDP).
(6) The distance between the end of fic and the start of pabA was 31 base pairs.
(7) Further, at the end of treatment fewer patients had depressive symptoms and the total daily number of hours of wellbeing and normal movement increased.
(8) DI James Faulkner of Great Manchester police said: “The men and women working in the factory have told us that they were subjected to physical and verbal assaults at the hands of their employers and forced to work more than 80-hours before ending up with around £25 for their week’s work.
(9) One rare case of blind-ending branch originating in the upper third of the ureter are described.
(10) Mapping of the cross-link position between U2 and U6 RNAs is consistent with base-pairing between the 5' domain of U2 and the 3' end of U6 RNA.
(11) Anthropometric and nutritional (serum albumin and transferrin) values were normal in both groups both at the beginning and at the end of the treatment period.
(12) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(13) Noradrenaline (NA) was released from sympathetic nerve endings in the tissue by electrical stimulation of the mesenteric nerves or by the indirect sympathomimetic agent tyramine.
(14) The B cell epitopes included regions of transition between the more hydropathic (including the N-terminal end of the F1 and F2 protein) and hydrophilic sequences.
(15) According to the national bank, four Russian banks were operating in Crimea as of the end of April, but only one of them, Rossiisky National Commercial Bank, was widely represented, with 116 branches in the region.
(16) This paper reports, principally, the caries results of the first three surveys of 5, 12 and 5-year-olds undertaken at the end of 1987, 1988 and 1989, respectively.
(17) For dental procedures requiring tracheal intubation, one could perhaps use non-depolarizing muscle relaxants, like pancuronium, with reversal at the end of the procedure.
(18) For retrospective action to be taken, and an FA charge to follow, the decision of the panel must be unanimous.” The match between the sides ended in acrimony and two City red cards.
(19) The number of peripheral blood lymphocytes (PBL) producing IgM (spontaneous and pokeweed mitogen (PWM) stimulated) at the end of a seven day culture period was similar in PBC patients and control subjects while the amount of IgM synthesized (spontaneous and PWM stimulated) during this period was significantly greater in the patient group, implying that the amount of IgM produced per B cell was increased in PBC.
(20) ACh released from the vesicular fraction was about 100-fold more than could be accounted for by miniature end-plate potentials; possible causes of this overestimate are discussed.
Terminus
Definition:
(n.) Literally, a boundary; a border; a limit.
(n.) The Roman divinity who presided over boundaries, whose statue was properly a short pillar terminating in the bust of a man, woman, satyr, or the like, but often merely a post or stone stuck in the ground on a boundary line.
(n.) Hence, any post or stone marking a boundary; a term. See Term, 8.
(n.) Either end of a railroad line; also, the station house, or the town or city, at that place.
Example Sentences:
(1) Conditions for limited digestion of the heterodimer by subtilisin, removing only the carboxyl terminus, were determined.
(2) The elongation of helix III with the addition of helix II at the N-terminus somewhat stabilizes the ordered structure.
(3) Synthetic DNA corresponding to the hydrophobic domain of cytochrome b5 was enzymatically fused in-frame to cloned DNA corresponding to the C-terminus of the Escherichia coli enzyme, beta-galactosidase.
(4) TCR beta chain gene expression of individual T cell clones that share the same MHC class II restriction and similar fine specificity for the encephalitogenic NH2 terminus of the autoantigen myelin basic protein (MBP) has been examined.
(5) When these sequences were fused to the N terminus of yeast cytochrome oxidase subunit IV lacking its own presequence, they directed the attached subunit IV to its correct intramitochondrial location in vivo.
(6) Both proteins appeared to be recognized by antibodies against the amino (N) terminus of the alpha 1 subunit sequence.
(7) These plasmin-cleaved peptides are derived from the COOH terminus of C2b, and they induce the contraction of estrous rat uterus.
(8) From the decreased alignment at the N-terminus and the presence of additional residues compared with bacterial phosphorylases, we conclude that the regulatory sequences that also carry the phosphorylation site in the muscle enzyme were joined to a presumed ancestral precursor gene by gene fusion after separation of the eukaryotic and prokaryotic lines of descent.
(9) Microsequencing of the peptides resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicates that the amino terminus of the protein is disposed at or near the cytoplasmic surface of the gap junction, and that this surface also contains a protease-hypersensitive hydrophilic sequence between residues 109 and 123, presumably connecting the second and third transmembrane segments.
(10) The N-terminal sequence (15 amino acid residues) of the L-proline activating fragment obtained by trypsin treatment was identical with that of GS2, indicating that the L-proline activating site is located at the N-terminus of the native synthetase.
(11) It is suggested that a general manner of folding may be a common feature of the heterogeneous population of kappa-chains: one bridge which folds an invariable stretch of the chain, another bridge which folds a stretch that varies from protein to protein, and a bridge at the C-terminus which is the interchain link.
(12) Cysteine proteinase I cleaved peptides primarily from the C-terminal region of Tg, which contained two major hormonogenic sites, while cathepsin-B produced peptides mainly from the N-terminus, containing another major hormonogenic site.
(13) Deletions from the N terminus of LMM did not alter the solubility properties of the expressed material, but deletion of 92 residues from the C terminus caused a large increase in solubility at low ionic strength, indicating that a determinant important for interaction between LMM molecules was located in this region.
(14) Middle component particles of bean pod mottle virus (BPMV) containing small protein subunits with a cleaved C terminus were used to produce monoclonal antibodies (MAbs).
(15) We find that the NH2-terminus of PTH is rapidly degraded in situ by the liver but that both liver and especially kidney nevertheless contain low levels of NH2-terminal PTH fragments that, although not released into the blood, are large enough to be potentially active.
(16) 2) By contrast, the COOH terminus is an inhibitory regulator of mitogenesis, and removal of the terminal 43 amino acids converts the receptor from a moderately active growth signaler to a very active one.
(17) Since the HPV-16 E6-promoted degradation involves the ubiquitin-dependent proteolysis pathway, specific mutations were made in the amino terminus of p53 to examine whether the E6 targeted degradation involved the N-end rule pathway.
(18) Examination of the inhibitory effect of ATP using oligo(dA)12-18 as well as activated DNA as primers revealed that (a) ATP inhibition is not due to its addition onto a 3'-OH primer terminus ad judged by the lack of incorporation of labeled ATP, although under similar conditions incorporation of GTP can be demonstrated, (b) a consistent degree of inhibition was noted independent of primer or enzyme concentration; (c) addition of ATP to an ongoing reaction promptly reduces the rate of polymerization; (d) kinetic studies indicate a competitive (with respect to substrate deoxy triphosphate) pattern of inhibition; (e) addition of excess deoxyribotriphosphate promptly relieves the inhibition.
(19) A peptide corresponding to the COOH terminus (residues 45-65) was synthesized utilizing lysine 47 as a specific residue to conjugate to thyroglobulin as a carrier for raising antibodies in mice.
(20) Myristic acid-labeled virions contained a single radioactive protein, p10, supporting the mapping of this molecule to the amino terminus.