(n.) The extreme or last point or part of any material thing considered lengthwise (the extremity of breadth being side); hence, extremity, in general; the concluding part; termination; close; limit; as, the end of a field, line, pole, road; the end of a year, of a discourse; put an end to pain; -- opposed to beginning, when used of anything having a first part.
(n.) Point beyond which no procession can be made; conclusion; issue; result, whether successful or otherwise; conclusive event; consequence.
(n.) Termination of being; death; destruction; extermination; also, cause of death or destruction.
(n.) The object aimed at in any effort considered as the close and effect of exertion; ppurpose; intention; aim; as, to labor for private or public ends.
(n.) That which is left; a remnant; a fragment; a scrap; as, odds and ends.
(n.) One of the yarns of the worsted warp in a Brussels carpet.
(v. t.) To bring to an end or conclusion; to finish; to close; to terminate; as, to end a speech.
(v. t.) To form or be at the end of; as, the letter k ends the word back.
(v. t.) To destroy; to put to death.
(v. i.) To come to the ultimate point; to be finished; to come to a close; to cease; to terminate; as, a voyage ends; life ends; winter ends.
Example Sentences:
(1) These included bringing in the A* grade, reducing the number of modules from six to four, and a greater attempt to assess the whole course at the end.
(2) The oral nerve endings of the palate, the buccal mucosa and the periodontal ligament of the cat canine were characterized by the presence of a cellular envelope which is the final form of the Henle sheath.
(3) A full-length cDNA encoding porcine heart aconitase was derived from lambda gt10 recombinant clones and by amplification of the 5' end of the mRNA.
(4) The present findings indicate that the deafferented [or isolated] hypothalamus remains neuronally isolated from the environment if the operation is carried out later than the end of the first week of life.
(5) In patients with coronary artery disease, electrocardiographic signs of left atrial enlargement (LAE-negative P wave deflection greater than or equal to 1 mm2 in lead V1) are associated with increased left ventricular end diastolic pressure (LVEDP).
(6) The distance between the end of fic and the start of pabA was 31 base pairs.
(7) Further, at the end of treatment fewer patients had depressive symptoms and the total daily number of hours of wellbeing and normal movement increased.
(8) DI James Faulkner of Great Manchester police said: “The men and women working in the factory have told us that they were subjected to physical and verbal assaults at the hands of their employers and forced to work more than 80-hours before ending up with around £25 for their week’s work.
(9) One rare case of blind-ending branch originating in the upper third of the ureter are described.
(10) Mapping of the cross-link position between U2 and U6 RNAs is consistent with base-pairing between the 5' domain of U2 and the 3' end of U6 RNA.
(11) Anthropometric and nutritional (serum albumin and transferrin) values were normal in both groups both at the beginning and at the end of the treatment period.
(12) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(13) Noradrenaline (NA) was released from sympathetic nerve endings in the tissue by electrical stimulation of the mesenteric nerves or by the indirect sympathomimetic agent tyramine.
(14) The B cell epitopes included regions of transition between the more hydropathic (including the N-terminal end of the F1 and F2 protein) and hydrophilic sequences.
(15) According to the national bank, four Russian banks were operating in Crimea as of the end of April, but only one of them, Rossiisky National Commercial Bank, was widely represented, with 116 branches in the region.
(16) This paper reports, principally, the caries results of the first three surveys of 5, 12 and 5-year-olds undertaken at the end of 1987, 1988 and 1989, respectively.
(17) For dental procedures requiring tracheal intubation, one could perhaps use non-depolarizing muscle relaxants, like pancuronium, with reversal at the end of the procedure.
(18) For retrospective action to be taken, and an FA charge to follow, the decision of the panel must be unanimous.” The match between the sides ended in acrimony and two City red cards.
(19) The number of peripheral blood lymphocytes (PBL) producing IgM (spontaneous and pokeweed mitogen (PWM) stimulated) at the end of a seven day culture period was similar in PBC patients and control subjects while the amount of IgM synthesized (spontaneous and PWM stimulated) during this period was significantly greater in the patient group, implying that the amount of IgM produced per B cell was increased in PBC.
(20) ACh released from the vesicular fraction was about 100-fold more than could be accounted for by miniature end-plate potentials; possible causes of this overestimate are discussed.
Upstream
Definition:
(adv.) Toward the higher part of a stream; against the current.
Example Sentences:
(1) The latter result indicates that the dexamethasone block is upstream from release of esterified arachidonic acid.
(2) Other DNase I hypersensitive sites located adjacent to the S14 cap site at -65 to -265 base pairs (Hss-1) or upstream at -1.3 kb (Hss-2), -2.1 kb (Hss-3'), -5.3 kb (Hss-4), and -6.2 kb (Hss-5) remained unaffected by changes in S14 gene transcription.
(3) No other essential regulatory sequence is located further upstream.
(4) Analysis of glutamate dehydrogenase (GDH) expression by enzyme assay and immunoblots, as well as Northern and dot blots of poly (A)+ RNA, in the deletion strains indicates that there are two upstream regulatory sequences that control the level of gene expression.
(5) Although the islet promoter was found to lack a TATA box, a major transcript from the islet promoter was mapped 486 nucleotides upstream of the translation initiation site.
(6) If this is the only issue, flight would be fine, but need to make sure that it isn’t symptomatic of a more significant upstream root cause.” Elon Musk (@elonmusk) Btw, 99% likely to be fine (closed loop TVC wd overcome error), but that 1% chance isn't worth rolling the dice.
(7) There was an upstream "HTF" island (Hpa II tiny fragments) followed by four direct repeats of the "chorion box" enhancer.
(8) Six discrete 'phased' nucleosomes are present upstream from the gene and are modulated by induction.
(9) That the opposite was observed in our study indicates that the increase in Pst(L), which results from parenchymal hysteresis, offsets any dimensional decrease in upstream airways due to airways hysteresis.
(10) The human gene-specific upstream stimulatory transcription factor (USF) is required, both in vivo and in vitro, for maximal expression of the major late promoter (MLP) of adenovirus.
(11) A single upstream CCAAT element is essential for high level expression in both liver and non-liver cells.
(12) Deletional analysis demonstrated that a region between -86 and -70 nucleotides upstream from the transcriptional origin of the human VIP gene was responsible for stimulation by forskolin.
(13) The gradient of increasing copper and zinc concentrations with increasing distance upstream from the mouth of the estuary reported in 1975 could not be statistically validated.
(14) By using primer 1 (5'-AAAGAATTCATGGAATCCAGGATCTG-3', upstream nucleotides 157 to 2877), primer 2 (5'-AAAGAATTCATGAACGTGAAGGAATCG-3', upstream nucleotides 1846 to 2877), and primer 4(5'-ATAAAGCTTAATCAGACGTTCTCTTCTTC-3', downstream nucleotides 157 to 2877 and 1846 to 2877), the HCMV B gene code region sequence and its glycoprotein 52 kd antigenic domain sequence were amplified from the recombinant plasmid pBH1 DNA containing the HCMV B gene.
(15) The sequence TAGAAAA was found 30 bases upstream from the transcription initiation site and could be analogous to the TATA box.
(16) A potential ribosome binding site was located 20 nucleotides upstream of the initiation codon in the 5' noncoding region.
(17) A 1,300-base pair fragment of 5'-flanking sequence containing these elements, ligated upstream from a firefly luciferase reporter gene and transfected into cultured normal rat kidney cells, demonstrated strong promoter activity.
(18) Since these three mutants differ in the extent to which EBNA expression is impaired, the data suggest that there are several critical regions upstream of the open reading frame that regulate EBNA expression in COS-1 cells.
(19) One class II mutant carried a Tn10 insertion in or close to malT whereas in the remaining class II mutants the insertions were located at least 4 kb upstream of pulA in a region which may define a new regulatory locus of the maltose operon.
(20) We report here that a nuclear protein is tightly bound to the HBV genome at a position approximately 190 bases upstream from the S gene promoter.