(1) Furthermore, comparison of these studies has revealed a differential dose response relationship between the number of graft lymphocytes, protection of engraftment, and induction of acute GVHD.
(2) Engraftment of donor cells was documented by HLA typing of peripheral lymphocytes.
(3) Glucose response to an arginine challenge was initially abnormal in both groups of mice, but was identical to normal controls 4 months after transplantation, showing that engraftment is a gradual process.
(4) Studies in severe combined immunodeficient mice that were engrafted with selected lymphocyte subpopulations show that B cells, and hence anti-Cryptococcus antibodies, are not necessary for the CD4+ T cell-dependent responses that isolate and subsequently destroy this opportunistic pathogen in the lung parenchyma.
(5) Marrow depleted of T cells exhibited reduced engraftment in the recipient fetuses.
(6) Treating bone marrow with MoAbs to myeloid differentiation antigens does not interfere with pluripotential stem cell engraftment.
(7) Prophylaxis by T cell depletion is associated with increased rates of engraftment failure and leukemic relapse.
(8) Posttransplant recovery was uneventful, and engraftment was comparable to that in 4 patients treated with a similar preparative regimen followed by infusion of autologous marrow.
(9) Ten dogs were given a combination of mAb 7.2 pregrafting and MTX after grafting, and 9 had evidence of engraftment.
(10) Three patients who received T-cell-depleted marrow cells from HLA-haploidentical donors failed to engraft and other graft failures were due to inadequate induction dosage.
(11) The in vivo use of an anti-CD11a-LFA-1 antibody as an additional immunosuppressive therapy in HLA-nonidentical BMT may thus promote engraftment and survival with correction of the primary disease in a significant number of patients with life-threatening immunodeficiency and osteopetrosis, but not with Fanconi's anemia.
(12) All four patients achieved quick engraftment, and three of the four patients are alive and well today.
(13) Engraftment has been sustained for one year and the patient is in normal health and has normal in vitro immunological function.
(14) Three of the seven surviving patients have durable engraftment (greater than 230 to greater than 550 days) while four patients have autologous hematopoietic recovery.
(15) All patients who failed to show engraftment or who rejected their bone marrow graft within three weeks had serum inhibitory to normal bone marrow cell culture, but inhibition could not be demonstrated against autologous bone marrow cells in these patients with aplastic anaemia.
(16) This study demonstrated that poor engraftment was a frequent complication of ABMT when early posttransplant cytotoxic therapy was attempted.
(17) The progressive disappearance of this autoreactivity was correlated with the engraftment of Ia-positive cells (monocytes plus B lymphocytes) of donor origin and the achievement of complete immunological reconstitution.
(18) Researchers are currently trying to reduce the RR by intensifying the conditioning regimen or using the graft-versus-leukemia effect of allogeneic T cells, reducing GvHD by the use of monoclonal antibodies, and improving the engraftment by the use of growth factors.
(19) The present work suggests that fetal liver infusion given following induction chemotherapy may increase the remission rate in AML either by temporary engraftment or by accelerating the rate of haematological recovery.
(20) These mice developed an active inflammatory myopathy beginning 15 days after engraftment.
Graft
Definition:
(n.) A small shoot or scion of a tree inserted in another tree, the stock of which is to support and nourish it. The two unite and become one tree, but the graft determines the kind of fruit.
(n.) A branch or portion of a tree growing from such a shoot.
(n.) A portion of living tissue used in the operation of autoplasty.
(n.) To insert (a graft) in a branch or stem of another tree; to propagate by insertion in another stock; also, to insert a graft upon.
(n.) To implant a portion of (living flesh or akin) in a lesion so as to form an organic union.
(n.) To join (one thing) to another as if by grafting, so as to bring about a close union.
(n.) To cover, as a ring bolt, block strap, splicing, etc., with a weaving of small cord or rope-yarns.
(v. i.) To insert scions from one tree, or kind of tree, etc., into another; to practice grafting.
Example Sentences:
(1) In this study of ten consecutive patients sustaining molten metal injuries to the lower extremity who were treated with excision and grafting, treatment with compression Unna paste boot was compared with that with conventional dressing.
(2) These immunocytochemical studies clearly demonstrated that cells encountered within the fibrous intimal thickening in the vein graft were inevitably smooth muscle cell in origin.
(3) An effective graft-surveillance protocol needs to be applicable to all patients; practical in terms of time, effort, and cost; reliable; and able to detect, grade, and assess progression of lesions.
(4) On the basis of 180 interventions, they describe in detail the use of fibrin glue in myringo- and tympanoplasty for correct fixing of grafts.
(5) Graft life is even more prolonged with patch angioplasty at venous outflow stenoses or by adding a new segment of PTFE to bypass areas of venous stenosis.
(6) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(7) The article describes an unusual case with development of a right anterior mediastinal mass after bypass surgery with internal mammary artery grafts.
(8) In our experience DSA is a safe, specific means of following postoperative grafts and diagnosing their occlusion.
(9) Factors associated with higher incidence of rejection included loose sutures, traumatic wound dehiscence, and grafts larger than 8.5 mm.
(10) The result of this study demonstrates that both the "hat" and "inverted" type grafts are highly successful and satisfactory procedures.
(11) It is concluded that fibroblast replication is an important mechanism leading to the pathologic fibrosis seen in graft versus host disease and, by analogy, probably other types of immunologically mediated fibrosis.
(12) The in vivo approach consisted of interspecies grafting between quail and chick embryos.
(13) Attachment of the graft to the wound is similar with and without the addition of human basic fibroblast growth factor, a potent angiogenic agent, to the skin replacement before graft placement on wounds.
(14) A conduit of a diameter of 23 mm was made by hand with a glutaraldehyde preserved xenopericardial graft.
(15) The remaining grafts appeared to be incorporated securely, as determined by radiographic examination.
(16) Attempts were made to prolong the survival of the grafts by the use of cytotosine arabinoside, methylprednisolone, heparin and azathioprine.
(17) Grafts of intermediate thickness (M III) showed excellent clinical healing of the donor and the recipient site.
(18) It was recently demonstrated that MRL-lpr lymphoid cells transferred into lethally irradiated MRL- +mice unexpectedly failed to induce the early onset of lupus syndrome and massive lymphadenopathy of the donor, instead they caused a severe wasting syndrome resembling graft-vs-host (GvH) disease.
(19) Living nonrelated transplants and 0-haplotype matched transplants did well initially at 1-year graft survival but there was a decrease in graft survival in these transplant groups at 2 and 3 years.
(20) Fascia TM grafts atrophied in 35 of 43 ears (80%), and perichondrium atrophied in 8 of 20 ears (40%).