(a.) Indented with small concave curves, as the edge of a bordure, bend, or the like.
Example Sentences:
(1) An ectopic expression assay in Drosophila embryos was used to investigate the roles of pair-rule segmentation genes in the spatial regulation of the segment-polarity gene, engrailed (en).
(2) Engrailed has been suggested to play an important role during development by controlling position-specific characteristics in the CNS of the early embryo.
(3) The engrailed gene is required during embryogenesis of Drosophila melanogaster for normal segmental development and for differentiation of posterior compartments.
(4) Genetic analysis in Drosophila has shown that engrailed (en) plays an important role in segmentation and neurogenesis.
(5) The first pattern of expression is in alternating segments followed by expression in every segment, suggesting that engrailed may be responding to pair-rule segmentation gene products.
(6) By contrast, the homeo box within the engrailed gene diverges substantially and, unlike the other homeo boxes, is interrupted by an intervening sequence.
(7) These results indicate that 1) Engrailed-2 expression is suppressed in the most ventral neural tube owing to induction of the floor plate by the notochord, and 2) that the presence of an underlying notochord is not required for correct rostrocaudal expression, suggesting that multiple pathways act in the patterning of the rudiment of the central nervous system.
(8) The crystal structure of a complex containing the engrailed homeodomain and a duplex DNA site has been determined at 2.8 A resolution and refined to a crystallographic R factor of 24.4%.
(9) This early requirement for engrailed does not appear to be a maternal function, and only genetically engrailed embryos displayed these precellular phenotypes.
(10) No other transcribed regions were found up to 16 kb downstream and 48 kb upstream of the engrailed transcription unit, the portion of the genome to which engrailed mutations have been mapped.
(11) Comparison of amino acid sequences between the entire Xenopus En-2 and the Drosophila engrailed proteins confirms conservation of sequences inside as well as proximal to the homeobox and reveals a region of similarity towards the N terminus.
(12) The Drosophila engrailed gene product (En) is a homeodomain-containing protein that contributes to segmental patterning.
(13) These results are discussed in the context of an autoregulatory model for engrailed regulation.
(14) hh expression in epidermal cells is confined to the posterior compartments and coincides precisely with that of engrailed (en).
(15) An enzyme system that accurately initiates transcription of the engrailed gene has been prepared from Drosophila embryos.
(16) We have examples of patches of hairy cells (where we monitor the effect on fushi tarazu (ftz) expression), even-skipped (monitoring ftz) and ftz (monitoring engrailed and Ultrabithorax).
(17) By examining embryonic expression of the mouse engrailed (En) genes, from 8.0 to 9.5 days postcoitum, we demonstrate that Wnt-1 primarily regulates midbrain development.
(18) This gene, which encodes a transmembrane protein, is initially expressed in a generalized way at blastoderm, but later stops being transcribed in cells expressing the engrailed gene, and even later in cells in the middle of the parasegment.
(19) Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.
(20) It appears to control morphogenesis by regulating the expression of the segmentation gene engrailed (en), and by autoregulating its own expression (M. Frasch and M.L., in preparation).
Indent
Definition:
(v. i.) To contract; to bargain or covenant.
(v. t.) To notch; to jag; to cut into points like a row of teeth; as, to indent the edge of paper.
(v. t.) To dent; to stamp or to press in; to impress; as, indent a smooth surface with a hammer; to indent wax with a stamp.
(v. t.) To bind out by indenture or contract; to indenture; to apprentice; as, to indent a young man to a shoemaker; to indent a servant.
(v. t.) To begin (a line or lines) at a greater or less distance from the margin; as, to indent the first line of a paragraph one em; to indent the second paragraph two ems more than the first. See Indentation, and Indention.
(v. t.) To make an order upon; to draw upon, as for military stores.
(v. i.) To be cut, notched, or dented.
(v. i.) To crook or turn; to wind in and out; to zigzag.
(n.) A cut or notch in the man gin of anything, or a recess like a notch.
(n.) A stamp; an impression.
(n.) A certificate, or intended certificate, issued by the government of the United States at the close of the Revolution, for the principal or interest of the public debt.
(n.) A requisition or order for supplies, sent to the commissariat of an army.
Example Sentences:
(1) Over a period of 9 months a 12-year-old girl spontaneously developed a palpable cystic tumor in the upper eye lid which led to an indentation and downward displacement of the globe.
(2) Attachment appeared to involve a very close physical proximity of treponemes to the cultured cells; at the site of attachment, no changes such as swelling or indentation of the cultured cell surface were observed.
(3) Analysed were the results of surgical treatment, causes of the failure and early recurrence in 108 patients with retinal detachment in whom was performed an indentation of the sclera by means of a balloon (1st group--50) or by an episcleral implant (2d group--58).
(4) Thus, the area with separated HL, which is restricted to the region of the PMC released at the stage of PMC ingression, spreads almost entirely throughout the area of the indenting vegetal plate at gastrulation.
(5) Evidence for net C3 synthesis was based on (a) incorporation of 14C-labeled amino acids into C3 protein, (b) indentity of the allotype of C3 produced in vitro with that of the doner's serum C3, even in the presence of carrier C3 protein of a different allotype; (c) correspondence of electrophoretic mobility, size, and subunit structure of C3 protein produced in vitro with serum C3; (d) inhibition of C3 production with cycloheximide.
(6) The light touch stimulus was a slight indentation of the skin produced through a displacement controlled stimulating probe (tip diameter of 2 mm).
(7) Dendritic cells were characterized by their slender cytoplasmic processes, indented nucleus and pale cytoplasm.
(8) The monocytes are large cells with an indented nucleus and cytoplasm containing numerous vesicles of different sizes and also a few lysosomes.
(9) Kitten units responsive to skin indentation showed no evidence of encoding stimulus magnitude information.
(10) The anti-inflammatory effect of dexamethasone was also indentical in both normal and EFAD rats.
(11) (1) was employed to calculate the strain rate and stress from the indentation time and the size of the indentation.
(12) A mathematical solution has been obtained for the indentation creep and stress-relaxation behavior of articular cartilage where the tissue is modeled as a layer of linear KLM biphasic material of thickness h bonded to an impervious, rigid bony substrate.
(13) The responses of slowly-adapting neurons were separated into two components, a "dynamic" response corresponding to activity elicited by the initial indenting ramp and a "static" response produced by the sustained indentation.
(14) Therefore, the pleural indentation sign does not exclusively appear in the lung cancer.
(15) In the fluoride group, a moderate increase of the indentation length and a reduced calcium loss were observed.
(16) Histologically, in addition to diffuse infiltrate of large lymphoid cells with deeply indented nuclei, there were many epithelioid cell granulomas, remarkable tissue eosinophilia and stromal fibrosis, mimicking inflammatory disease.
(17) By utilizing high-speed, microcomputer-controlled data logging techniques, simultaneous monitoring of signals from a dynamic load cell and a displacement transducer could be made throughout an indentation test.
(18) The central axon of a primary afferent neuron that responded to indentation of the glabrous skin of the lower lip in a slowly adapting fashion was intra-axonally injected with horseradish peroxidase.
(19) In addition to the macroglossia, the typical facial signs of this syndrome such as capillary haemangioma of the glabella, soft tissue folds under the eyes and linear indentations of the ear lobes are demonstrable.
(20) Cuplike indentations were present on the paunch epithelial surface and were sites of bacterial aggregation.