(a.) Indented with small concave curves, as the edge of a bordure, bend, or the like.
Example Sentences:
(1) An ectopic expression assay in Drosophila embryos was used to investigate the roles of pair-rule segmentation genes in the spatial regulation of the segment-polarity gene, engrailed (en).
(2) Engrailed has been suggested to play an important role during development by controlling position-specific characteristics in the CNS of the early embryo.
(3) The engrailed gene is required during embryogenesis of Drosophila melanogaster for normal segmental development and for differentiation of posterior compartments.
(4) Genetic analysis in Drosophila has shown that engrailed (en) plays an important role in segmentation and neurogenesis.
(5) The first pattern of expression is in alternating segments followed by expression in every segment, suggesting that engrailed may be responding to pair-rule segmentation gene products.
(6) By contrast, the homeo box within the engrailed gene diverges substantially and, unlike the other homeo boxes, is interrupted by an intervening sequence.
(7) These results indicate that 1) Engrailed-2 expression is suppressed in the most ventral neural tube owing to induction of the floor plate by the notochord, and 2) that the presence of an underlying notochord is not required for correct rostrocaudal expression, suggesting that multiple pathways act in the patterning of the rudiment of the central nervous system.
(8) The crystal structure of a complex containing the engrailed homeodomain and a duplex DNA site has been determined at 2.8 A resolution and refined to a crystallographic R factor of 24.4%.
(9) This early requirement for engrailed does not appear to be a maternal function, and only genetically engrailed embryos displayed these precellular phenotypes.
(10) No other transcribed regions were found up to 16 kb downstream and 48 kb upstream of the engrailed transcription unit, the portion of the genome to which engrailed mutations have been mapped.
(11) Comparison of amino acid sequences between the entire Xenopus En-2 and the Drosophila engrailed proteins confirms conservation of sequences inside as well as proximal to the homeobox and reveals a region of similarity towards the N terminus.
(12) The Drosophila engrailed gene product (En) is a homeodomain-containing protein that contributes to segmental patterning.
(13) These results are discussed in the context of an autoregulatory model for engrailed regulation.
(14) hh expression in epidermal cells is confined to the posterior compartments and coincides precisely with that of engrailed (en).
(15) An enzyme system that accurately initiates transcription of the engrailed gene has been prepared from Drosophila embryos.
(16) We have examples of patches of hairy cells (where we monitor the effect on fushi tarazu (ftz) expression), even-skipped (monitoring ftz) and ftz (monitoring engrailed and Ultrabithorax).
(17) By examining embryonic expression of the mouse engrailed (En) genes, from 8.0 to 9.5 days postcoitum, we demonstrate that Wnt-1 primarily regulates midbrain development.
(18) This gene, which encodes a transmembrane protein, is initially expressed in a generalized way at blastoderm, but later stops being transcribed in cells expressing the engrailed gene, and even later in cells in the middle of the parasegment.
(19) Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.
(20) It appears to control morphogenesis by regulating the expression of the segmentation gene engrailed (en), and by autoregulating its own expression (M. Frasch and M.L., in preparation).
Shield
Definition:
(n.) A broad piece of defensive armor, carried on the arm, -- formerly in general use in war, for the protection of the body. See Buckler.
(n.) Anything which protects or defends; defense; shelter; protection.
(n.) Figuratively, one who protects or defends.
(n.) In lichens, a Hardened cup or disk surrounded by a rim and containing the fructification, or asci.
(n.) The escutcheon or field on which are placed the bearings in coats of arms. Cf. Lozenge. See Illust. of Escutcheon.
(n.) A framework used to protect workmen in making an adit under ground, and capable of being pushed along as excavation progresses.
(n.) A spot resembling, or having the form of, a shield.
(n.) A coin, the old French crown, or ecu, having on one side the figure of a shield.
(n.) To cover with, or as with, a shield; to cover from danger; to defend; to protect from assault or injury.
(n.) To ward off; to keep off or out.
(n.) To avert, as a misfortune; hence, as a supplicatory exclamation, forbid!
Example Sentences:
(1) 11 patients with a postoperative classification of stage D had additional external beam radiation to the pelvic and paraaortic lymph nodes with shielding of the implanted prostatic region.
(2) An effective gonadal shield should reduce the gonadal dose to a level low enough to preserve spermatogenesis in most patients.
(3) Scott was born in North Shields, Tyne and Wear, the youngest of the three sons of Colonel Francis Percy Scott, who served in the Royal Engineers, and his wife, Elizabeth.
(4) Fred had to be substituted to shield him from the crowd’s disdain.
(5) Was the Dalkon Shield so harmful in the nulliparous woman?
(6) Physicians need to prescribe the lowest possible dose of hormones in these women and counsel them to shield their face from sunlight.
(7) Moulton said his colleagues were preparing to table an offer next week that will shield 50% of the council's staff from a pay cut.
(8) Adult males acclimated to an LD 14:10 photoperiod were distributed in five experimental groups: intact controls (NO), sham-pinealectomized (S), sham-pinealectomized with black plastic shielding of the pineal region, pinealectomized (PX), and pinealectomized with the operated region shielded.
(9) In order to evaluate long-term as well as short-term effects, blood loss was measured at postinsertion levels of 6, 12, and 18 months in 72 women wearing the Lippes loop, in 73 wearing the Dalkon shield, and in 82 with TCu 300.
(10) Using the outer 2 mm of the skin-fold, and shielding the rest of the hand with a lead plate, cutaneous blood flow rate could be monitored separately.
(11) Shielded marrow self renewal capacity, a measurement reflecting primitive hematopoietic stem cell function, remained depressed and did not recover with time.
(12) We believe the shield makes the patient more comfortable and decreases the likelihood of dislodgement of the adhesive.
(13) He lost contact with his father, a lorry driver, for several years, but says that his mother - aided by his uncle - made it her mission to shield him from the crime and disorder around them.
(14) The lead shield encloses only the testes, allowing its use with nearly any radiation field that does not include the testes.
(15) "Let us arm ourselves with the weapon of knowledge and let us shield ourselves with unity and togetherness," Malala said.
(16) I’m not satisfied until I collect everything' … EFL Cup Europa League International Champions Cup Community Shield Which competition was Ian Rush talking about when he said: 'This is why cup finals are so special, because anyone can beat anyone.
(17) Nemanja Matic, more normally such a man-mountain of a midfield shield, is diminished and was beaten too easily in the air by James Morrison for the home side’s second.
(18) The results indicate that collagen shields can slowly release cyclosporin A and increase the penetration time for the drug.
(19) Shields accepted that the Irish appeared more inclined to send up their grim fiscal situation than go out and riot.
(20) Some Coalition MPs raised concerns earlier this year that transparency could expose wealthy business owners to security risks, including kidnapping , and the government prepared legislation to shield private Australian companies.