(v. t.) To wind off; to loose or separate, as what or convolved; to untwist; to untwine; as, to unwind thread; to unwind a ball of yarn.
(v. t.) To disentangle.
(v. i.) To be or become unwound; to be capable of being unwound or untwisted.
Example Sentences:
(1) Unlike cisplatin, bis(platinum) complex binding does not unwind supercoiled DNA.
(2) Of the 47 compounds that were positive or equivocal in the alkaline unwinding assay, only carbon tetrachloride and prednisolone were negative in the mouse lymphoma assay, while 12 of the 19 compounds that were negative in the alkaline unwinding assay were positive in the mouse lymphoma assay.
(3) As suggested from the high level of sequence similarity of these viral proteins with the recently described superfamilies of helicase-like proteins (3-5), the NTBM-containing cylindrical inclusion (CI) protein from plum pox virus (PPV), which belongs to the potyvirus group of positive strand RNA viruses, is shown to be able to unwind RNA duplexes.
(4) This limited unwinding of heterologous duplex DNA, termed heterologous unwinding, was detected within 30 seconds and reached a steady state within a few minutes.
(5) Comparison of the superhelix densities obtained by both methods permits a calculation of an unwinding angle for ethidium.
(6) The exposure of the cells from mussel haemolymph and from mouse L1210 to a genotoxic compound such as dimethylsulfate results in DNA damage and consequently in a reduction of the unwinding time.
(7) As for unwinding, the rituals of it give a satisfying end to the shape of my day.
(8) Chromosome replication appears to initiate in E. coli when the dnaA boxes in oriC become filled with DnaA protein, which could simultaneously mediate both the unwinding of the origin for the start of polymerization and the attachment of oriC to the cell envelope (Bramhill and Kornberg, 1988; Løbner-Olesen et al., 1989; Pierucci et al., 1989).
(9) The protein fraction containing the 93 000 dalton protein had considerable unwinding activity, depressing the melting temperature of poly(dA-dT) by 39 degrees C. The protein fraction containing the bulk of the 35 000 dalton protein did not have unwinding activity.
(10) The required cellular protein may be a eukaryotic single-stranded-DNA-binding protein (SSB), since unwinding of the template is also observed when Escherichia coli SSB is substituted for the HeLa protein fraction.
(11) Evidence is presented that the first step in initiation of SV40 DNA replication involves the specific binding of T antigen to the origin, followed by the local unwinding of the two strands of the template.
(12) Complex formation leads to very little, if any, unwinding of the duplex.
(13) It is suggested that the gene D product may function in replicative form DNA unwinding to expose the template for transcription.
(14) Topotecan (SK&F 104864) is a novel antitumor agent whose mechanism of action is inhibition of the DNA unwinding protein topoisomerase I.
(15) We used an RNA unwinding assay to compare the activities of these factors from the different species.
(16) The extension and unwinding of the DNA helix brought about by the intercalating chromophore of the dye molecules are not requirements for the entrapment process.
(17) Second, mutant T antigens with impaired ATPase function also showed a reduced DNA unwinding activity.
(18) Analysts at UBS said: “After Friday’s ... market plunge, many turned to the authorities for support measures as concerns rose that the rapid unwinding of margin trades was fuelling the sell-off.
(19) It is proposed that the DNA-unwinding activity causes the efficient recombination, DNA repair, and SOS induction (after application of nalidixic acid) in recD mutants.
(20) But within minutes of the five-year-old video of Obama being released by the Daily Caller website on Tuesday night , the "exclusive" began to unwind amid criticism that much of it had been reported at the time and the content was anything but explosive.