(n.) The theory of generation which holds that the germ is created entirely new, not merely expanded, by the procreative power of the parents. It is opposed to the theory of evolution, also to syngenesis.
Example Sentences:
(1) Here, however, it is shown that a more general version of epigenesis can be held, because of a new principle which states that it is mathematically possible to obtain not only a convergent generation of form, or structure, but also a convergent generation of information.
(2) The study suggests that various second-trimester prenatal disturbances in the epigenesis of one twin in a pair discordant for schizophrenia may be related to the fact that only one of the twins expresses his or her genetic predisposition toward schizophrenia.
(3) A quantitative re-examination was made of the influence of noradrenergic depletion on the epigenesis of kitten visual cortex.
(4) This, the first linear morphometric analysis of the epigenesis of the fetal mammalian adrenal cortex, has shown that in the fetal sheep during the latter two thirds of gestation and in the newborn lamb, there are two periods of rapid growth separated by a period of much reduced growth.
(5) The epigenesis of the different muscles is related to the appearance of their various functions.
(6) Two sequential stages occur: 1) the realisation of an intrinsic programme of maturation, by which cortical specificity appears at eye opening and increases independently of visual experience 2) a phase of "epigenesis" beginning at 19 days, during which functional modification depends on visual experience.
(7) It has been observed that the activity of acid phosphatase does not remain constant, but undergoes changes at different phases of epigenesis.
(8) We report here that functional changes in single neurons of area 17, analogous to those known to take place during epigenesis of visual cortex, can be induced experimentally during the time of recording.
(9) Next, epigenetic influences on synaptogenesis are examined, and later in the article the concept of epigenesis is integrated with that of hierarchy.
(10) A mathematical modeling approach called epigenesis theory is presented which relates three aspects of pathogenesis to the population distribution of disease.
(11) The activity rhythmically becomes higher and lower throughout the whole period of epigenesis.
(12) Both specific epigenesis and specific cell kinetics are involved.
(13) The theory of epigenesis is the undisputed paradigm of embryology, and it is still based on the classical concept proposed by Aristotle: the idea that embryonic development is a generation of structures which takes place according to a design--today we say a set of instructions--already present in the fertilized egg.
(14) Epigenesis theory unifies the sufficient-component causes model and the simple independent action model and exceeds either model in the range of observations it can explain.
(15) Epigenesis theory defines the following multivariable relations between two disease causes: 1) "Complementary" causes contribute different causal actions to the sole pathogenic process leading to disease.
(16) Models of disease causation pertinent to IDDM are presented with a primary focus on the recently developed epigenesis theory.
Epigenetic
Definition:
(a.) Of or pertaining to the epigenesis; produced according to the theory of epigenesis.
Example Sentences:
(1) Although each of palate and limb is concurrently susceptible to epigenetic regulation, their differential intrinsic genomic capabilities appear to have been uncoupled.
(2) The incomplete penetrance of the neoplastic phenotype and the monoclonality of lymphoid tumors suggest that tumor formation in v-fps mice requires genetic or epigenetic events in addition to expression of the P130gag-fps protein-tyrosine kinase.
(3) Incomplete penetrance of the simpler pattern suggests that this genetic locus interacts in a probabilistic manner with epigenetic mechanisms involved in morphogenesis of the cerebellum.
(4) The literature, mainly from non-neural tissues, suggests derepression of normally silent genes, possibly in association with DNA demethylation; decreased synthesis of neuronal rRNA due to deletion of rRNA genes; epigenetic changes in hnRNA splicing; reduced turnover rates and the accumulation of nonfunctional proteins.
(5) The technique is specific, sensitive, and reliable for the routine detection of genetic and epigenetic variation in thyroxin-binding globulin.
(6) An integration of the mutation and epigenetic theories of cancer with the "two-stage" theory and Comings's general theory of carcinogenesis is proposed.
(7) Since no random decline in DNA methylation could be detected in any of the cases, our results suggest that it is unlikely that mortality of cells in culture is the outcome of random loss of epigenetic control imposed by 5-methyldeoxycytidine at CpG sites in the genome.
(8) Although the sequence of events involved in triggering differentiation is uncertain, cloning and cell hybridization experiments demonstrate that this phenotype is under rather stable genetic (or epigenetic) control.
(9) Leukocyte interferon genes could not be mapped to these chromosomes, but this negative result could be influenced by the epigenetic state of the hybrid cells.
(10) The results obtained following manipulation of the otocyst indicate the major role of extrinsic (epigenetic) parameters in normal skeletogenesis and emphasize an apparent discrepancy between the normal and potential expansion of a bone.
(11) Psychiatrists have also pinpointed anomalies that might be explained by epigenetics.
(12) The process of cancer causation involves a series of steps that can be classified broadly into (a) the definition of DNA-reactive carcinogens and (b) the assessment of enhancing or inhibiting epigenetic agents.
(13) These epigenetic marks seem to outline those two women.
(14) The model can be used to assess the importance of chromosomal damage such as mitotic recombination and epigenetic mechanisms such as hyperplasia and cytotoxicity in the onset of malignant tumors.
(15) Experimental evidence also points towards a largely epigenetic mode of pattern specification.
(16) The evidence favors an epigenetic rather than a genetic origin of the variations in appearance and behavior of the subpopulations.
(17) This review covers the basis for distinguishing between carcinogens that have either DNA reactivity or epigenetic activity as their primary effect.
(18) The long latent period, the evidence of cell degeneration, necrosis, foreign material (probably of nickel composition), cell invasion, and subsequent rapid myofibroblast-type cell development, proliferating to malignant tumors highly suggestive of malignant fibrous histiocytoma, seem to suggest an epigenetic form of carcinogenicity of cytotoxic variety.
(19) The highly similar karyotypes of both components suggest that the phenotypic difference is predominantly epigenetically determined.
(20) Early studies on heritable variation in cultured mammalian cells suggested that both mutation and epigenetic events might be involved.