What's the difference between epigenetic and transvection?
Epigenetic
Definition:
(a.) Of or pertaining to the epigenesis; produced according to the theory of epigenesis.
Example Sentences:
(1) Although each of palate and limb is concurrently susceptible to epigenetic regulation, their differential intrinsic genomic capabilities appear to have been uncoupled.
(2) The incomplete penetrance of the neoplastic phenotype and the monoclonality of lymphoid tumors suggest that tumor formation in v-fps mice requires genetic or epigenetic events in addition to expression of the P130gag-fps protein-tyrosine kinase.
(3) Incomplete penetrance of the simpler pattern suggests that this genetic locus interacts in a probabilistic manner with epigenetic mechanisms involved in morphogenesis of the cerebellum.
(4) The literature, mainly from non-neural tissues, suggests derepression of normally silent genes, possibly in association with DNA demethylation; decreased synthesis of neuronal rRNA due to deletion of rRNA genes; epigenetic changes in hnRNA splicing; reduced turnover rates and the accumulation of nonfunctional proteins.
(5) The technique is specific, sensitive, and reliable for the routine detection of genetic and epigenetic variation in thyroxin-binding globulin.
(6) An integration of the mutation and epigenetic theories of cancer with the "two-stage" theory and Comings's general theory of carcinogenesis is proposed.
(7) Since no random decline in DNA methylation could be detected in any of the cases, our results suggest that it is unlikely that mortality of cells in culture is the outcome of random loss of epigenetic control imposed by 5-methyldeoxycytidine at CpG sites in the genome.
(8) Although the sequence of events involved in triggering differentiation is uncertain, cloning and cell hybridization experiments demonstrate that this phenotype is under rather stable genetic (or epigenetic) control.
(9) Leukocyte interferon genes could not be mapped to these chromosomes, but this negative result could be influenced by the epigenetic state of the hybrid cells.
(10) The results obtained following manipulation of the otocyst indicate the major role of extrinsic (epigenetic) parameters in normal skeletogenesis and emphasize an apparent discrepancy between the normal and potential expansion of a bone.
(11) Psychiatrists have also pinpointed anomalies that might be explained by epigenetics.
(12) The process of cancer causation involves a series of steps that can be classified broadly into (a) the definition of DNA-reactive carcinogens and (b) the assessment of enhancing or inhibiting epigenetic agents.
(13) These epigenetic marks seem to outline those two women.
(14) The model can be used to assess the importance of chromosomal damage such as mitotic recombination and epigenetic mechanisms such as hyperplasia and cytotoxicity in the onset of malignant tumors.
(15) Experimental evidence also points towards a largely epigenetic mode of pattern specification.
(16) The evidence favors an epigenetic rather than a genetic origin of the variations in appearance and behavior of the subpopulations.
(17) This review covers the basis for distinguishing between carcinogens that have either DNA reactivity or epigenetic activity as their primary effect.
(18) The long latent period, the evidence of cell degeneration, necrosis, foreign material (probably of nickel composition), cell invasion, and subsequent rapid myofibroblast-type cell development, proliferating to malignant tumors highly suggestive of malignant fibrous histiocytoma, seem to suggest an epigenetic form of carcinogenicity of cytotoxic variety.
(19) The highly similar karyotypes of both components suggest that the phenotypic difference is predominantly epigenetically determined.
(20) Early studies on heritable variation in cultured mammalian cells suggested that both mutation and epigenetic events might be involved.
Transvection
Definition:
(n.) The act of conveying or carrying over.
Example Sentences:
(1) Chromosomal rearrangements which disrupt transvection possess a breakpoint in a particular segment of the chromosome arm bearing the transvection-sensitive gene (arm 2L for the DDP-C and 3R for the BX-C); this segment of each arm has been termed the critical region by Lewis (1954).
(2) The zeste gene product is required for transvection effects that imply the ability of regulatory elements on one chromosome to affect the expression of the homologous gene in a somatically paired chromosome.
(3) The factor Dichaete (D3) permits easier scoring of the transvection phenotype.
(4) Possible mechanisms for the trans-acting effect of niv-525 and its relationship to other examples of allelic interactions, such as transvection in Drosophila melanogaster, are discussed.
(5) These results indicate that both the zeste-white interaction and transvection effects require the formation of high order aggregates.
(6) We discuss the normal cis regulatory role of these functions involved in trans interactions between homologous Ubx genes, as well as the implications of our results for the current models on transvection.
(7) Only Cbx2 and CbxIRM (a revertant of Cbx1) show synapsis-dependent gene expression ("transvection").
(8) These recent observations continue a history of studies concerning zeste and transvection which has inspired molecular models linking chromosome structure and positioning to the modulation of gene expression.
(9) Somatic transfer of genomic imprinting between homologs by means of a transvection-like process between paired Tme and T loci is proposed as a model to explain the results obtained.
(10) We show that this domain is responsible for the extensive aggregation properties of zeste that are required for its role in transvection phenomena.
(11) A new adaptation of the bithorax transvection method by Mendelson permits the recovery of high yields of chromosome aberrations in a fast one-generation test.
(12) We have confirmed that, although the Ubx1 allele does not produce detectable Ubx proteins (UBX), it does retain other genetic functions detectable by their effects on the expression of a paired, homologous Ubx allele, i.e., by transvection.
(13) The conditions necessary for each transvection effect were determined from these transvection groups.
(14) The genetic properties of the proximity-dependent allelic complementation (termed transvection effects) at the BX-C and DPP-C, are quite similar.
(15) Transvection was explained by trans-activation of promoter in y2-allele by enhancer of y1-allele.
(16) The bithorax34e mutation only transvects with Ultrabithorax mutations with a contiguous Ultrabithorax transcriptional unit.
(17) The zeste gene product is involved in two types of genetic effects dependent on chromosome pairing: transvection and the zeste-white interaction.
(18) Special attention is paid to the transvection effect (synapsis-dependent interaction between white and zeste genes), cis-acting regulatory elements and the behaviour of the white genes introduced into the genome by P element-mediated DNA transformation.
(19) Surprisingly, previous genetic experiments indicate that zeste is a nonessential gene shown only to act in a dispensable regulatory process termed transvection.
(20) One can discriminate between otherwise phenotypically similar mutations via their transvection behavior.