(n.) An alkaloid found in the Calabar bean, and the seed of Physostigma venenosum; physostigmine. It is used in ophthalmic surgery for its effect in contracting the pupil.
Example Sentences:
(1) The preparation was mounted in an organ bath and superfused with Tyrode solution containing hemicholinium-3 and eserine.
(2) Differences in Ca2+-binding between normotensive and hypertensive groups (human as well as rats) was found under eserine influence.
(3) By use of different activators and inhibitors, TOCP(tri-o-cresyl phosphate), PCMB (parachloromercury benzoate), NiCl2, Pb(NO3)2, HgCl2, Hg(NO3)2, eserine and sodium taurocholate, it is shown that the esterase in the cyst cells and in group I cells of the guinea pig thyroid probably are A-esterase isoenzymes.
(4) Vidian nerve stimulation causes a significant decrease in histamine content and mast cell density in the mucosa sample, differentially influenced by eserine and atropine pretreatment.
(5) Furthermore, eserine pretreatment did not increase denervated muscle sensitivity to acetylcholine.
(6) It is inhibited by fluoride, but insensitive to eserine or p-chloromercuriphenylsulfonate.
(7) Whereas atropine reduced the amplitude of the second PS elicited by 1 microM DFP and 10 microM eserine, neither atropine nor quinuclidinyl benzylate affected the amplitude of the second PS in 10 microM DFP or 100 microM eserine.
(8) The "alpha-like" activity is due to a monomer enzyme (MW congruent to 60 kd) having a nonspecific tissue distribution, which was inhibited by p-hydroxymercuribenzoate (5 X 10(-4)M) plus eserine (1 X 10(-5)M) and was relatively unstable during polyacrylamide gel electrophoresis.
(9) Upon perfusion with acetylcholine (+ 0,1 mM eserine), the mean gastrin levels in the effluent increased within 2 min to 4 times the basal level, while there was a smaller second release after 20 min.
(10) Carbachol, eserine, and acetylcholine produced a synchronization of slow wave activity (theta) accompanied by depression of perforant path to dentate field potentials.
(11) After administration of eserine, a new acetylcholine (ACh) subfraction called f+ is formed in rat brain tissue.
(12) In voltage-clamp recording, eserine reduced a current termed IAHP.
(13) It is concluded that 10 microM DFP and 100 microM eserine have effects in field CA1 that are probably not mediated by cholinergic mechanisms.
(14) Eserine reversed the paralysis only in the first days but was ineffective in the "chronic" stage of the disease.
(15) Eserine (20 microM) and carbachol (200 microM) increased peak response amplitudes by up to 80% within 5-10 min, and amplitudes remained elevated during 20-33 min of continued treatment.
(16) The administration of eserine and nicotine induced slow wave theta in the hippocampus accompanied by the increased discharge rate of tonic theta-on cingulate cells.
(17) Pimozide, a long-acting dopamine receptor antagonist, abolished the effect of eserine, whereas domperidone, which has the same pharmacological properties but does not cross the blood brain barrier, failed to do so.
(18) These effects are enhanced by an acetylcholinesterase inhibitor, eserine, and blocked by the muscarinic antagonists, pirenzepine and atropine.
(19) This increase was not affected by removal of extracellular calcium, by hemicholinium-3 (a blocker of high-affinity choline uptake) or eserine.
(20) Usually no repolarization was seen during long pulses of carbamylcholine or long pulses of acetylcholine in the presence of eserine or neostigmine.
Serine
Definition:
(n.) A white crystalline nitrogenous substance obtained by the action of dilute sulphuric acid on silk gelatin.
Example Sentences:
(1) Addition in the cultures of 4-deoxypyridoxine, a potent antagonist of vitamin B6 coenzymes, concurrently with the mitogen, inhibits the induction of serine hydroxymethyltransferase.
(2) Amino acid analysis indicated a significant number of serine amino acids: N-terminal sequence data demonstrated a high level of homology; and trypsin digestion followed by reversed-phase HPLC indicated the possibility of multiple phosphorylation sites.
(3) Plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of tissue-type plasminogen activator (t-PA) in plasma, is a serine proteinase inhibitor (serpin) that forms a 1:1 stoichiometric complex with its target proteinase leading to the formation of a stable inactive complex.
(4) The alterations in DS frontal cortex included decreases in (n-6) and increases in (n-3) groups in choline and ethanolamine phosphoglycerides (CPG and EPG), as had previously been found in EPG and serine phosphoglyceride (SPG) of the DS fetal brain.
(5) A significant proportion of the soluble protein of the organic matrix of mollusk shells is composed of a repeating sequence of aspartic acid separated by either glycine or serine.
(6) Serine (12.0-18.2%), tyrosine (5.8-9.0%) and glycine (4.5-7.1%), along with arginine, make up the bulk of the amino acid residues in these molecules.
(7) Serine inhibited the ethanolamine incorporation by this preparation and ethanolamine inhibited the serine incorporation.
(8) The exceptions were the levels of threonine, glutamine, serine and histidine, which were three times greater in brain than in serum.
(9) Phosphorylation of serine occurs mostly (Sp H1) or entirely (Sp H2B) on the N-terminal portions of these molecules.
(10) The structural region contains serines, threonines, and cysteines at exactly the positions required to give mature nisin by a series of post-translational modifications involving dehydration of serines and threonines to dehydro forms, and cross-linking with cysteine residues.
(11) Two-dimensional phosphopeptide map analysis revealed that the major sites of tyrosine and serine phosphorylation in PLC-gamma 1 from activated Jurkat cells are the same as those in PLC-gamma 1 from cells treated with peptide growth factors such as epidermal growth factor and platelet-derived growth factor.
(12) Phosphate appears to be incorporated solely into serine residues.
(13) Other amino acids (glutamine, taurine, asparagine, alanine, serine) were only altered in single brain regions, or were not altered at all (aspartate, glycine, threonine, arginine).
(14) To gain further insight into the side chain requirement at position 177 that confers maltose recognition, further substitutions of isoleucine, leucine, phenylalanine, proline, and serine have been made via site-directed mutagenesis.
(15) Phosphoamino acid analysis showed that histidyl-tRNA synthetase is phosphorylated on serine, as has previously been shown for threonyl-tRNA synthetase of CHO cells.
(16) We present evidence that over-expression of human plasminogen, the precursor to the serine protease plasmin, can be cytotoxic to mammalian cells.
(17) Sodium Acetate, Arginine, Cysteine, Leucine, Norleucine, Methionine and Serine (more than 50%).
(18) Pancreatic and urinary kallikreins failed to form the typical serine proteinase complex with alpha2M (alpha2-macroglobulin).
(19) Serine deletion was also shown to be position-specific.
(20) The data obtained testify to the presence in the granular fraction of the endopeptidase LTH-converting activity which is sensitive to pepstatin A, an aspartyl proteinase inhibitor as well as to chelators and a serine proteinase inhibitor.