(a.) To make stable or firm; to fix immovably or firmly; to set (a thing) in a place and make it stable there; to settle; to confirm.
(a.) To appoint or constitute for permanence, as officers, laws, regulations, etc.; to enact; to ordain.
(a.) To originate and secure the permanent existence of; to found; to institute; to create and regulate; -- said of a colony, a state, or other institutions.
(a.) To secure public recognition in favor of; to prove and cause to be accepted as true; as, to establish a fact, usage, principle, opinion, doctrine, etc.
(a.) To set up in business; to place advantageously in a fixed condition; -- used reflexively; as, he established himself in a place; the enemy established themselves in the citadel.
Example Sentences:
(1) Similar experimental manipulation has yielded in vitro lines established from avian B-cell lymphomas expressing elevated levels of c-myc or v-rel.
(2) The liver metastasis was produced by intrasplenic injection of the fluid containing of KATOIII in nude mouse and new cell line was established using the cells of metastatic site.
(3) The role of whole Mycobacteria, mycobacterial cell walls and waxes D as immunostimulants was well established many years ago.
(4) A backbench policy advisory group will be established to develop ideas.
(5) Since it was established, it has stoked controversy about contemporary art, though in recent years it has been more notable for its lack of sensationalism.
(6) Nasotracheal intubation has been well established as a method for maintaining an artificial airway in children.
(7) Using multiple regression, a linear correlation was established between the cardiac index and the arterial-venous pH and PCO2 differences throughout shock and resuscitation (r2 = .91).
(8) Developing seminiferous tubules and interstitial cells were first seen on day 26, and were well established one day later.
(9) In three of these patients this was associated with the presence of a previously well established abscess cavity.
(10) To identify the NHE-1 protein and to establish its cellular and subcellular localization in the rabbit kidney, we prepared antibodies to a NHE-1 fusion protein.
(11) The structures of 1 and 2 were established mainly on the basis of nmr spectroscopic data.
(12) It was established that nonsurgical methods of transplantation with laboratory animals were less time-consuming and were more readily applicable.
(13) The haplotype of the recombinant X chromosome of each of 241 backcross progeny has been established using the X-linked anchor loci Otc, Hprt, Dmd, Pgk-1, and Amg and the additional probes DXSmh43 and Cbx-rs1.
(14) We found that, although controlled release delivery of ddC inhibited de novo FeLV-FAIDS replication and delayed onset of viremia when therapy was discontinued (after 3 weeks), an equivalent incidence and level of viremia were established rapidly in both ddC-treated and control cats.
(15) After several months, a temporal discrimination was well established, as shown by maximum suppression toward the end of the signal period.
(16) An experimental model was established in the ewe allowing one to predict with accuracy an antral follicle that coincidentally would either undergo ovulation (6-8 mm diameter) or atresia (3-4 mm diameter) following synchronization of luteal regression and the onset of the gonadotropin surge.
(17) In 8 of 32 patients (25%) the diagnosis was established only at autopsy.
(18) For the second propositus, a woman presenting with abdominal and psychiatric manifestations, the age of onset was 38 years; the acute attack had no recognizable cause; she had mild skin lesions and initially was incorrectly diagnosed as intermittent acute porphyria; the diagnosis of variegate porphyria was only established at the age of 50 years.
(19) We previously established that the binding constant (Ka) of this receptor site for the chemically synthesized model AGE, 2-(2-furoyl)-4(5)-(2-furanyl)-1H- imidazole-butyric acid (FFI-BA), on cells of the mouse macrophagelike cell line RAW 264.7 is identical to that for AGE proteins.
(20) Neil Blessitt Bristol • We need to establish what the legal position is with regard to the establishment by the government of a private company co-owned by the Department of Health and the French firm Sopra Steria.
Investigate
Definition:
(v. t.) To follow up step by step by patient inquiry or observation; to trace or track mentally; to search into; to inquire and examine into with care and accuracy; to find out by careful inquisition; as, to investigate the causes of natural phenomena.
(v. i.) To pursue a course of investigation and study; to make investigation.
Example Sentences:
(1) Lebedev says he is aware that he is under investigation.
(2) We have investigated the effect of methimazole (MMI) on cell-mediated immunity and ascertained the mechanisms of immunosuppression produced by the drug.
(3) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(4) Clinical and roentgenographic criteria could not discriminate between patients with and without pneumonia, confirming the findings of previous investigations.
(5) The combined immediate and delayed responses to fleas in the dog are as observed by other investigators in man and guinea pigs.
(6) "As the investigation remains live and in order to preserve the integrity of that investigation, it would not be appropriate to offer further comment."
(7) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(8) The ability of azelastine to influence antigen-induced contractile responses (Schultz-Dale phenomenon) in isolated tracheal segments of the guinea-pig was investigated and compared with selected antiallergic drugs and inhibitors of arachidonic acid metabolism.
(9) Electronmicroscopical investigations have revealed that, under normal conditions, a minor vesicular transfer of intravenously injected peroxidase occurs across the endothelium in segments of arterioles, capillaries and venules, especially in arterioles with a diameter about 15-30 mu.
(10) Using mini-pigs with an indwelling vascular catheter, the pharmacokinetics of chloramphenicol were investigated in healthy and liver-damaged animals.
(11) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(12) The quaternary structure of ribonucleotide reductase of Escherichia coli was investigated, with the use of purified B1 and B2 proteins and bifunctional cross-linking agents.
(13) We have investigated a physiological role of endogenous insulin on exocrine pancreatic secretion stimulated by a liquid meal as well as exogenous secretin and cholecystokinin octapeptide (CCK-8) in conscious rats.
(14) The subcellular distribution of sialyltransferase and its product of action, sialic acid, was investigated in the undifferentiated cells of the rat intestinal crypts and compared with the pattern observed in the differentiated cells present in the surface epithelium.
(15) We have investigated the increase in the spcDNA population upon cycloheximide treatment of individual sequences, which are found to amplify differentially.
(16) A phytochemical investigation of an ethanolic extract of the whole plant of Echites hirsuta (Apocynaceae) resulted in the isolation and identification of the flavonoids naringenin, aromadendrin (dihydrokaempferol), and kaempferol; the coumarin fraxetin; the triterpene ursolic acid; and the sterol glycoside sitosteryl glucoside.
(17) In the present investigation we monitored the incorporation of [14C] from [U-14C]glucose into various rat brain glycolytic intermediates of conscious and pentobarbital-anesthetized animals.
(18) Among the groups investigated, the subjects with gastric tumors presented the greatest values.
(19) Typological and archaeological investigations indicate that the church building represents originally the hospital facility for the lay brothers of the monastery, which according to the chronicle of the monastery was built in the beginning of the 14th century.
(20) Therefore, we have developed a powerful new microcomputer-based system which permits detailed investigations and evaluation of 3-D and 4-D (dynamic 3-D) biomedical images.