(1) The conceptual framework provides for both the variation in estr ogenic responses in various target organs.
(2) The in vitro metabolism of 7 alpha-methyl-19-nortestosterone (7 alpha-methyl-3-oxo-estr-4-ene-17 beta-ol) was investigated in male rat liver, ventral prostate, and epididymis.
(3) Fifty patients responded to treatment or had stable disease, and 28 did not respond (12 in the ORX and 16 in the ESTR group).
(4) This model of peripheral aromatization was utilized to evaluate in vivo pharmacological parameters of MDL 18,962 (10-(2-propynyl)estr-4-ene-3,17-dione) such as bioavailability of several formulations, time course and dose responses following different routes of drug administration, pharmacokinetics and tissue distribution of [14C]MDL 18,962.
(5) Both 10-[(1R)-1-hydroxyethyl]- and 10-[(1S)-1-hydroxyethyl]estr-4-ene-3,17-dione were oxygenated to 10-(1,1-dihydroxyethyl)estr-4-ene-3,17-dione and isolated following in situ dehydration as 10-acetylestr-4-ene-3,17-dione.
(6) Tissues were homogenized and incubated in vitro with labeled progesterone and 2 different antiovulatories, lynestrenol (17alpha-ethin yl-17beta-hydroxy-estr-4-one) and MK 665 (17alpha-chloroethinyl-19-nor-4 ,9(10)-androstadiene-17beta-ol-3-one).
(7) In contrast, both analogues of 19-hydroxyandrostenedione [10-[(1S)-1-hydroxyethyl]estr-4-ene-3,17-dione (2c) and 10-[(1R)-1-hydroxyethyl]estr-4-ene-3,17-dione (2e)] were converted to the intermediate analogue 3c in a process requiring O2 and either NADH or NADPH.
(8) 32 patients with high-risk pregnancies were treated with 3 X 5 mg of 17alpha-ally1-17beta-hydroxy-estr-4-ene (allylestrenol, Gestanon) daily.
(9) The key reaction in the synthesis of the hapten was the cuprate-mediated 1,4-conjugate addition on 3,3,17,17-bis-ethylenedioxy-5 alpha,10 alpha-oxido-estr-9(11)-ene by the Grignard reagent derived from trimethyl 4-bromoorthobutyrate; this regiospecifically introduces the 11 beta-butanoate function.
(10) All oxidative functions of aromatase, i.e., estrogen production, 19-oxygenated androgen production and 7-ethoxycoumarin deethylation, were inhibited in parallel in placental microsomes from non-smokers by the mechanism-based, time-dependent inactivators (suicide substrates) 10 beta-(2-propynyl)estr-4-ene-3,17-dione and 4-hydroxyandrost-4-ene-3,17-dione.
(11) The peripheral aromatization ([rho]BM) of androstenedione (A) and testosterone (T) was measured before and after administration of the aromatase inhibitor 10-(2 propynyl)estr-4-ene-3,17-dione (MDL-18,962) to five mature female baboons, Papio annubis.
(12) When microsomes were preincubated with the suicide substrates 10 beta-mercapto-estr-4-ene-3,17-dione (10 beta-SHnorA), or 17 beta-hydroxy-10 beta-mercaptoestr-4-ene-3-one (10 beta-SHnorT), it was found that 19-hydroxy-, 19-oxo- and aromatase activities were inhibited in parallel.
(13) The sulfate and phosphate conjugates of 19-nortestosterone (17beta-hydroxy-estr-4-ene-3-one) and ent-19-nortestosterone (ent-17beta-hydroxy-estr-4-ene-3-one) have been synthesized.
(14) Bioassays were conducted to determine various endocrinological properties of two spirolactone derivatives, 4',5'-dihydrospiro-[estr-4-ene-17,2'(3'H)-furan]-3-one (Compound I) and dispiro[cyclopropane-1,6'-estr-4'-ene-17',2"(3"h)-furan]-3'-one (Compound II).
(15) A convenient synthesis of both 5 beta,17 alpha-19-norpregn-20-yne-3 beta,17-diol (1) and 5 beta,17 alpha-19-norpregn-20-yne-3 alpha,17-diol (2) in multigram quantities from estr-4-ene-3,17-dione is reported.
(16) The compound 10-(2-propynyl)-estr-4-ene-3,17-dione is an effective inhibitor of the peripheral aromatization of both androstenedione and testosterone.
(17) The reversal potential of Str-induced current (EStr) was -75 mV, which was close to the K+ equilibrium potential (EK = -76.3 mV).
(18) The change in EStr for a ten fold change in extracellular K+ concentration was 58 mV, indicating that the membrane behaves like a K+ electrode in the presence of Str.
(19) The change of EStr for a ten fold change in extracellular K+ concentration was 58 mV, indicating that the membrane behaves like a K+ electrode in the presence of Str.
(20) The effect of silastic implants containing 0-5000 mcg of 17beta-estr adiol on serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin and their relationship to social cues was studied in adult, ovariectomized mice.
Layout
Definition:
Example Sentences:
(1) 31 junior high students and seven university undergraduates who graduated from the same junior high school seven years before were asked to draw a layout of the school campus.
(2) With no font preferences, every designer can do a picture-perfect layout on every screen, because they don't have to reflow the text accordingly, which is what websites should always do," he says.
(3) These charts facilitate the use of nonstandard testing distances which might be used when there is low visual acuity, when examination room layout prevents testing at the standard distance, or when it is necessary to validate visual acuity scores or detect malingering.
(4) The weekly titles will all be receiving new layout and design with a central section of common pages for the weeklies, drawn from the MEN's leisure and entertainment content.
(5) Work station design and layout play the most critical role in eliminating sources of postural problems.
(6) The strength of these associations was considered significant depending on the magnitude of the HOP ratio, the correlation coefficient, a two-way layout and relative risk (R.R.).
(7) Attention is focused on the problems arising from the community therapy context, the general layout of the setting, the definition of objectives and methods, and in particular the attitude of group leaders.
(8) Thus, both sacroiliac articulation and symphysis pubis show characteristic distribution of the subchondral bone density and layout of the tensile collagen fibrous material as expression of a strongly varying qualitative pattern of stress during walking.
(9) A spatial layout was used that minimized postperceptual errors in reporting location.
(10) After this a specific transducer layout is considered, which is suitable for in-plane measurements, and possible performances are evaluated by means of simulation.
(11) The program calculates most standard model fitting statistics for either overall or stratified analyses and uses data layout files compatible with those of other related epidemiologic analysis software.
(12) We report here on (1) a summary of the layout of cortical areas associated with vision and with other modalities, (2) a computerized database for storing and representing large amounts of information on connectivity patterns, and (3) the application of these data to the analysis of hierarchical organization of the cerebral cortex.
(13) In addition to repetitive motion, these factors included forceful manual exertions and awkward postures required by work station design and layout.
(14) All the problems which arose when the test sheet was filled out were recorded and subsumed into one of the following categories: comprehension problems, problems with the answer categories, answer tendency, problems with layout.
(15) These require careful layout to reduce electric and magnetic coupling, decoupling and filtering of power supplies and components, screening of RF circuits and particular attention to the reduction of power and computer signal currents flowing in RF signal earth paths.
(16) Problems are viewed as falling into several major categories: administration, personnel, location, space allocation, structural, layout, and undue reliance on generalized formulas.
(17) Dos Passos, like his innovative contemporary EE Cummings, played with typography and layout.
(18) Despite the problems with the structure, with its chaotic levels, leaking roofs, bewildering layout and dimly lit interiors, the building splendidly sited beside the handsome Victorian city hall and museum had passionate admirers.
(19) Actually, working with a game designer who knows their layout, colours and shape basics would be a treat beyond words, so you guys should totally take a look at that stuff too.
(20) It has been found out that the layout and arrangement of the wards are fully in keeping with the hygienic requirements on such specialized workplaces.