(1) The proposed assay should be useful for in vitro metabolic studies of 1,2-dihaloethanes and mustards and has potential application for similar studies of monohalogenated ethanes, ethanols, and ethenes.
(2) A total of nine chlorinated ethanes and ethenes were circulated over lithium hydroxide in a laboratory scale closed system simulator.
(3) The level of adducts from ethene, determined as N-(2-hydroxyethyl)valine, was also higher in mice from diet S than in animals fed diet C, when all treatment groups were considered.
(4) About equimolar concentrations of bleomycin and FeCl3 resulted in optimal ethene formation.
(5) Halogenated ethenes are oxidatively metabolized by cytochrome P-450 to intermediates which inactivate cytochrome P-450 by destroying heme and to epoxides which may react with cellular macromolecules or decompose to other products.
(6) Previous mixed-culture studies have demonstrated that complete dechlorination to ethene is possible, although the final dechlorination step from vinyl chloride to ethene is rate limiting, with significant levels of vinyl chloride typically persisting.
(7) The results demonstrate a raised level of hydroxyethylation of N-terminal valine of Hb of smokers that is quantitatively compatible with ethene in the smoke being the source.
(8) Lipid peroxidation and metabolism of intestinal bacteria, giving rise to ethene, precursor of ethylene oxide, are thus indicated to be sources of observed background hydroxyethylations.
(9) The bioconversions with the three most promising ethene-utilizers (M26, M90C, M93A) were scaled-up to yield essentially optically pure (enantiomeric excess = 93%) S-(+)-phenyl glycidyl ether.
(10) This figure is compatible with a metabolic conversion of 3% (1-10%) of the inhaled ethene to ethylene oxide.
(11) KMBA was converted to ethene by dithranol under aerobic conditions, whereas ethene formation was negligible in the absence of oxygen.
(12) Ethene formation depended on oxygen, NADPH, FeCl3 and the enzyme.
(13) The limitations of Fluosol DA led to fluorocarbons under investigation such as F dimethyl bicyclononanes, F methyladamantane, bis (F-butyl) ethene or F-octylbromide.
(14) Eighteen newly isolated ethene- and propene-utilizing bacteria were screened for the ability to produce phenyl glycidyl ether, a common precursor for the synthesis of beta blockers, from phenyl allyl ether.
(15) O2- - and .OH-scavengers such as rutin, catechin, dimethyl sulfoxide, mannitol, ethanol, sodium salicylate and propyl gallate as well as catalase and superoxide dismutase inhibited ethene formation.
(16) Because the singlet oxygen (1O2) sensitizer, rose bengale, showed enlarged production of ethene when irradiated in the presence of KMBA, experiments were performed in the dark in order to avoid 1O2 production by dithranol.
(17) Efforts to measure adducts originating from ethene in environmental tobacco smoke and urban air show, however, that the resolving power of the methods used for identifying unknown risk factors must be increased.
(18) The detection limit was one pmol ethene or ethane per five mL air sample; the within-run precision (CV) of analysis was 2.1 percent at an ethane concentration of 16 pmol per five mL sample.
(19) For unknown reasons, uninduced mice varied strongly in the extent to which they converted ethene to epoxide.
(20) A sixth chlorinated ethene, tetrachloroethylene, was not degraded by the methane-utilizing culture under these conditions.
Hydrocarbon
Definition:
(n.) A compound containing only hydrogen and carbon, as methane, benzene, etc.; also, by extension, any of their derivatives.
Example Sentences:
(1) The high transition enthalpy for kerasin is ascribed to a lesser accommodation of gauche conformers in the hydrocarbon chains just below the transition temperature.
(2) Aryl hydrocarbon hydroxylase (AHH) inducibility, carbon monoxide in expired air (CO), serum gammaglutamyl-transferase (GGT), and total cholesterol were compared in equal-sized, age-matched samples of healthy middle-aged males born in 1921, 1934-1936, and 1946 attending the ongoing preventive medical population program in Malmö.
(3) The length of the hydrocarbon chains of the surface-modified silica supports had no significant influence on the selectivity.
(4) The specificity of binding to microsomal proteins of metabolically activated hydrocarbons has been studied.
(5) Aryl hydrocarbon (benzo(a)pyrene) hydroxylase is present and inducible in Buffalo rat liver cells in culture.
(6) The possible occupational cause of the disease, as more solvents in the mud have the structure of aromatic hydrocarbons is discussed.
(7) Experiments with a series of adsorbents homologous with CPAD-Sepharose, in which the length of the hydrocarbon chain was varied, provided strong evidence of hydrophobic interactions, in addition to ionic interactions, in the binding of these proteins to CPAD-Sepharose.
(8) In the hydrocarbon promotion study, dose related increases were observed in the incidence of ACF in male rats promoted with UG or 50 ppm TMP for 24 or 60 weeks.
(9) The results also demonstrated that there was not any apparent correlation between the receptor-binding avidities and in vitro monooxygenase enzyme-induction potencies for the most active polynuclear aromatic hydrocarbons.
(10) Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent.
(11) Pancreas transplantation offers the possibility of preventing the development and progression of diabetic lesions by adequate control of hydrocarbon metabolism.
(12) A comparison of the relative cytosolic Ah (9S) receptor binding affinities and aryl hydrocarbon hydroxylase (AHH) induction potencies of these hydrocarbons with their 4S protein binding affinities demonstrated the following: five compounds, namely 1,2,5,6-dibenz[a]-anthracene, 1,2,3,4-dibenz[a]anthracene, picene, benzo[a]pyrene and 3-methylcholanthrene exhibited high to moderate binding affinities for the 4S and 9S cytosolic proteins (EC50 values less than 10(-6) M) and induced AHH in rat hepatoma cells; three compounds, namely perylene, benzo[e]pyrene and benzo[g,h,i]perylene exhibited high affinities for the 4S binding protein (1.25 X 10(-7), 4.4 X 10(-8) and 2.9 X 10(-8) M, respectively) and low affinities (EC50 values greater than 10(-5) M) for the Ah receptor protein; moreover these three compounds did not induce AHH in rat hepatoma H-4-II E cells in culture.
(13) It was found that HBSAg was strongly bound to straight hydrocarbon chains with more than seven carbon atoms.
(14) The parent hydrocarbons and the related K-region dihydrodiols induced some sister-chromatid exchanges but they were considerably less active than these two non-K-region diols.
(15) The effect of various fuel additives on the ability of platinum-palladium catalytic converters to remove the carbon monoxide and hydrocarbon components of automotive exhaust has been examined.
(16) Other chlorinated hydrocarbons as decachlorobiphenyl, pentachloronaphthalene, hexachloronaphthalene and hexachlorostyrene were identified, but not quantified.
(17) It has been estimated that natural oil seeps may also contribute as much as 10% of the hydrocarbons in the global marine environment.
(18) The metabolic fate of the carcinogenic aza-aromatic hydrocarbon 7-methyl[7-(14)C]benz[c]acridine (14C-7MBAC) was studied in hepatocytes freshly isolated from untreated, phenobarbital-pretreated and 3-methylcholanthrene-pretreated rats.
(19) Renal cytochrome P450, aryl hydrocarbon hydroxylase, 7-ethoxycoumarin-O-deethylase, and benzphetamine N-demethylase were increased after partial hepatectomy by 84%, 360%, 165% and 406%, respectively.
(20) Antioxidants devoid of hydrocarbon tails, are 10-20 fold more potent LPO inhibitors than the corresponding AOs with hydrocarbon tails.