(n.) A compound derived from ethyl alcohol by the replacement of the hydroxyl hydrogen, after the manner of a hydrate; an ethyl alcoholate; as, potassium ethylate, C2H5.O.K.
Example Sentences:
(1) This is the first clear example of activation of the K-ras gene by ethylating agents in a rodent lung tumor system.
(2) On the other hand, the hydrophilic reagents, 1-ethyl-3-[3-(dimethylamino)-propyl]carbodiimide and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, did not affect organic cation transport.
(3) The drug is extracted from serum or urine with ethyl acetate, separated by TLC, and determined by fluorescence quenching densitometry.
(4) Hemoglobin A reductively ethylated at the alpha-amino groups eluted on CM-52 ahead of unmodified hemoglobin A, and hemoglobin A reductively ethylated at the epsilon-amino groups.
(5) We have characterized the effects of adenosine, the A1-receptor agonist N6-(L-2-phenylisopropyl)-adenosine (PIA) and the A2-receptor agonist 5'-(N-ethyl)-carboxamido-adenosine (NECA), in isolated human pulmonary vessels.
(6) In comparison to rat pancreas, [D-Phe6]BN-(6-13)ethyl ester, Ac-GRP-(20-26)ethyl ester, [D-Phe6,Cpa14, psi 13-14]BN-(6-14), [Leu14, psi 13-14]BN, and [Leu14, psi 9,10]BN had a 10,000-, 2,940-, 1,425-, 122-, and 4-fold, respectively, weaker affinity for BN receptors.
(7) Imported sweets and liqueurs were homogenized and extracted with ethyl acetate.
(8) These results, in addition to binding studies with the active site titrant N2-(5-dimethylaminonaphthalene-1-sulfonyl)arginine N-(3-ethyl-1,5-pentanediyl)amide, indicate that binding interactions at the catalytic site of Thrombin Quick I are unaltered.
(9) Plasma samples are extracted at pH 9.6 with ethyl acetate after the addition of sodium bisulphite and the internal standard oxprenolol.
(10) Ethyl oleate-hydrolyzing activity was about one-eighth of the synthesizing activity.
(11) We have used a variety of chemical and enzymatic probes: dimethylsulfate, N-cyclohexyl-N'-(2-(N-methylmorpholino)-ethyl)-carbodiimide-p-tolu enesulfonate) , RNase T1 and RNase V1.
(12) The digestive juice showed no action on acetyl-L-tyrosine and benzoyl-L-arginine ethyl esters.
(13) The effect of subchronic feeding of 2,2'-oxamidobis[ethyl 3(3,5-di-tert-butyl-4-hydroxyphenyl) propionate], Naugard XL-1 (CAS number 70331-94-1), was studied in beagle dogs.
(14) After about 3 weeks of culture, N-ethyl-N-nitrosourea-pretreated fetal rat brain cells showed focal proliferation of neural cells on an underlayer of flat, epithelioid cells.
(15) [1-(beta,beta-Pentamethylene-beta-mercaptopropionic acid),2-(O-ethyl)-D- tyrosine,4-valine,9-desglycine]arginine-vasopressin (SK&F 101926, 1), a potent in vivo and in vitro vasopressin V2 receptor antagonist, was recently tested in human volunteers and shown to be a full antidiuretic agonist.
(16) On the basis of spectral and chemical evidence, pedicularioside E and F were identified to be 1'-O-beta-D-(3-methoxy-4-hydroxy-beta-phenyl)-ethyl-6'-O-feruloyl- alpha-L-(2-acetyl)-rhamnosyl-(1----3')-4'-acetylglucopyranoside and shanzhisin methyl ester cellobioside, respectively.
(17) Cross-linking of the one-to-one complex of actin and depactin with 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide (EDC) generated two types of cross-linked products with slightly different apparent molecular weights, denoted as 60KU and 60KL.
(18) ICI 74 205, a synthetic analogue of prostaglandin F2 alpha (PGF2a) with an alkyl side chain extended by an ethyl group, was administered intravenously in 6 patients using normal saline as the vehicle.
(19) Enzyme activity is inhibited by p-chloromercuriphenyl sulfonic acid, quinacrine dihydrochloride, and N-ethyl-maleimide.
(20) Quantitative studies show that the amount of compound solubilized is proportional to the LPC concentration and that solubilization increases in the order ethyl, n-propyl and n-butyl ester.
Methylate
Definition:
(n.) An alcoholate of methyl alcohol in which the hydroxyl hydrogen is replaced by a metal, after the analogy of a hydrate; as, sodium methylate, CH3ONa.
(v. t.) To impregnate or mix with methyl or methyl alcohol.
Example Sentences:
(1) Phospholipid methylation in human EGMs is distinctly different from that in rat EGMs (Hirata and Axelrod 1980) in that the human activity is not Mg++-dependent, and apparent methyltransferase I activity is located in the external membrane surface.
(2) Structure assignment of the isomeric immonium ions 5 and 6, generated via FAB from N-isobutyl glycine and N-methyl valine, can be achieved by their collision induced dissociation characteristics.
(3) Microionophoretically applied excitatory amino acids induced firing of extracellularly recorded single units in a tissue slice preparation of the mouse cochlear nucleus, and the similarly applied antagonist 2-amino-5-phosphonovalerate (2APV) was demonstrated to be a selective N-methyl-D-aspartate (NMDA) receptor antagonist.
(4) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(5) The enzyme was solubilized by Triton X-100 and purified approximately 480-fold by gel filtration and affinity chromatography on alanine methyl ketone-AH-Sepharose 4B.
(6) Glycosyl ceramide concentration was determined by gas-liquid chromatography of the trimethylsilyl ethers of the methyl glycosides.
(7) We have measured the antibody specificities to the two polysaccharides in sera from asymptomatic group C meningococcal carriers and vaccinated adults by a new enzyme-linked immunosorbent assay (ELISA) procedure using methylated human serum albumin for coating the group C polysaccharide onto microtiter plates.
(8) A new type of Escherichia coli mutant which shows increased sensitivity to methyl methane sulfonate but not to UV light or to gamma rays was isolated after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine.
(9) The effect of S-adenosylhomocysteine on DNA methylation was examined, and it was found at equal molar concentrations of S-adenosylhomocysteine to to S-adenosylmethionine that DNA methylation was competitively inhibited 50%.
(10) Thermal stabilities (Tm's) of the hybrid between the 2'-O-methyl ribooligomer and the complementary ribooligomer and of the related hybrids are compared.
(11) Intoxicating concentrations of ethanol also inhibit excitatory synaptic transmission mediated by N-methyl-D-aspartate receptors in hippocampal slices from adult rodents.
(12) S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine.
(13) Immunocytochemical analyses of the hippocampus demonstrated that alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate receptor subunits are present in the cell bodies and dendrites of pyramidal cells.
(14) It was concluded that the detachment of the oxaloyl residue from oxaloacetate and its replacement by a proton proceed with inversion of configuration at the methylene group which becomes methyl during the hydrolysis.
(15) These products were identified to be epimers of 5,12(S)-dihydroxy-eicosatetraenoic acid methyl ester (5,12(S)-diHETE-Me) and epimers of 11,12-diHETE-Me.
(16) CCK-8 was acylated with the iodinated aryl azide derivatives, methyl-3-azido-4-hydroxy-5-[125I]iodobenzimidate and N-[4-(4'-azido-3'-[125I]iodophenylazo)benzoyl]-3-aminopropionyl-N- oxy- succinimide.
(17) Substitution of NaCl in the extracellular medium by sucrose, LiCl, or Na2SO4 had no effect on glutamate stimulation of [3H]dopamine release; however, release was inhibited when NaCl was replaced by choline chloride or N-methyl-D-glucamine HCl.
(18) Incubation of membrane with DL-Hcys alone (5 X 10(-5) M), the combination of both Ad (5 X 10(-5)) and DL-Hcys (5 X 10(-5)), or S-adenosyl-L-homocysteine (SAH) (1 X 10(-6)) strongly decreased the methyl ester formation.
(19) The 1-0-methylalduronic-acidmethylesters, obtained by the methanolysis of the polysaccharides, are reduced with boronhydrid to the corresponding methyl glycosides; there are split with acid to the aldoses, which are converted in pyridine with hydroxylamine to the aldoximes and than with acetic anhydride to the aldonitrilacetates, which can be separated by gaschromatography without difficulty.
(20) The effects of postnatal methyl mercury exposure on the ontogeny of renal and hepatic responsiveness to trophic stimuli were examined.