(1) PAAG-electrophoresis of the isogenic pair of Rickettsia prowazekii strains E and Evir lysates demonstrate the similarity in polypeptide tracks.
(2) The strains under study have been divided into two groups according to the character of differences in their restrictograms: the group of virulent typing strain Breinl (Breinl, G. Anan'ev) and the group of strain E with low pathogenicity (E, EVir, Katsinian).
(3) Immunoblot analysis with immune rabbit sera to the strain E, EVir, and Breinl showed differences in immunological response to the 70 kD and 60 kD polypeptides of low virulent strain E and those of virulent strains EVir and Breinl.
(4) The sensitivity of some cell cultures to different R. prowazekii strains (strain E with low pathogenicity, virulent strain Breinl, strains ERifRI and EVir) has been studied with a view to the selection of an adequate culture for growing these strains and the study of their biological properties.
(5) The DNA of Rickettsia prowazekii vaccine strain E was analysed by restriction analysis with 17 endonucleases in comparison with its virulent revertant - Evir and the virulent reference strain Breinl.
(6) The high immunogenicity of the protein antigens of E, EVir and Breinl strains was demonstrated by immunoblot assay with human sera, which did not show any differences between the strains studied.
(7) In spite of stable differences in virulence, strains E and Evir displayed a totally identical DNA cleavage pattern indicating the absence of marked structural differences between their genomes.
(8) The protein antigens of two distinct lines of genetically related strains, namely the nonpathogenic strain E and its virulent revertant EVir and of the standard virulent strain Breinl were compared in SDS-PAGE and immunoblot assay using typhus patient sera and immune rabbit sera.
(9) The major M(r) 100 kD protein (protein I) from the standard virulent R. prowazekii strain Breinl, from the nonvirulent strain E and its virulent revertant EVir were isolated by chromatography and characterized.
(10) Protein I from virulent strains Breinl and EVir differed from that of nonpathogenic strain E by the quantity of N epsilon-Me-Lys and N epsilon-Me3-Lys, but all had the same total amount of Lys and its derivatives.
(11) No differences in the polypeptide pattern as detected in SDS-PAGE were found between strain E and EVir; the Breinl strain differed in a 30 kD protein.
(12) On the other hand 9 endonucleases showed differences in the restrictograms of the DNA strain Breinl as compared with strains E and Evir.
(13) In immunoblot experiments the specific rabbit antiserums obtained on the 30th day of infection with the Breinl, E or Evir strains demonstrate the presence of the different main antigens 60 Kd or 70 Kd.
Weak
Definition:
(v. i.) Wanting physical strength.
(v. i.) Deficient in strength of body; feeble; infirm; sickly; debilitated; enfeebled; exhausted.
(v. i.) Not able to sustain a great weight, pressure, or strain; as, a weak timber; a weak rope.
(v. i.) Not firmly united or adhesive; easily broken or separated into pieces; not compact; as, a weak ship.
(v. i.) Not stiff; pliant; frail; soft; as, the weak stalk of a plant.
(v. i.) Not able to resist external force or onset; easily subdued or overcome; as, a weak barrier; as, a weak fortress.
(v. i.) Lacking force of utterance or sound; not sonorous; low; small; feeble; faint.
(v. i.) Not thoroughly or abundantly impregnated with the usual or required ingredients, or with stimulating and nourishing substances; of less than the usual strength; as, weak tea, broth, or liquor; a weak decoction or solution; a weak dose of medicine.
(v. i.) Lacking ability for an appropriate function or office; as, weak eyes; a weak stomach; a weak magistrate; a weak regiment, or army.
(v. i.) Not possessing or manifesting intellectual, logical, moral, or political strength, vigor, etc.
(v. i.) Feeble of mind; wanting discernment; lacking vigor; spiritless; as, a weak king or magistrate.
(v. i.) Resulting from, or indicating, lack of judgment, discernment, or firmness; unwise; hence, foolish.
(v. i.) Not having full confidence or conviction; not decided or confirmed; vacillating; wavering.
(v. i.) Not able to withstand temptation, urgency, persuasion, etc.; easily impressed, moved, or overcome; accessible; vulnerable; as, weak resolutions; weak virtue.
(v. i.) Wanting in power to influence or bind; as, weak ties; a weak sense of honor of duty.
(v. i.) Not having power to convince; not supported by force of reason or truth; unsustained; as, a weak argument or case.
(v. i.) Wanting in point or vigor of expression; as, a weak sentence; a weak style.
(v. i.) Not prevalent or effective, or not felt to be prevalent; not potent; feeble.
(v. i.) Lacking in elements of political strength; not wielding or having authority or energy; deficient in the resources that are essential to a ruler or nation; as, a weak monarch; a weak government or state.
(v. i.) Tending towards lower prices; as, a weak market.
(v. i.) Pertaining to, or designating, a verb which forms its preterit (imperfect) and past participle by adding to the present the suffix -ed, -d, or the variant form -t; as in the verbs abash, abashed; abate, abated; deny, denied; feel, felt. See Strong, 19 (a).
(v. i.) Pertaining to, or designating, a noun in Anglo-Saxon, etc., the stem of which ends in -n. See Strong, 19 (b).
(a.) To make or become weak; to weaken.
Example Sentences:
(1) There was a weak relation between AER and both systolic and diastolic blood pressures.
(2) Muscle weakness and atrophy were most marked in the distal parts of the legs, especially in the gastrocnemius and soleus muscles, and then spread to the thighs and gluteal muscles.
(3) Consensual but rationally weak criteria devised to extract inferences of causality from such results confirm the generic inadequacy of epidemiology in this area, and are unable to provide definitive scientific support to the perceived mandate for public health action.
(4) The strengths and weaknesses of each technique are described in this article.
(5) In group V, five cases of Taenia saginata parasitosis were studied showing a weak positive reading.
(6) Although the longest period required for resolving weakness was three days, the MRI, the CT and the electroencephalogram revealed no significant abnormality.
(7) Her muscle weakness and hyperCKemia markedly improved by corticosteroid therapy, suggesting that the diagnosis was compatible with polymyositis (PM).
(8) It was concluded that Ta acts as a weak zeitgeber in laboratory rats and has greater effects on males compared to females.
(9) And adding to this toxic mix, was the fear that the hung parliament would lead to a weak government.
(10) Sensory loss, motor weakness, paraesthesia and a new pain were found as complications in 12, 7, 4 and 6 patients, respectively.
(11) Here's Dominic's full story: US unemployment rate drops to lowest level in six years as 288,000 jobs added Michael McKee (@mckonomy) BNP economists say jobless rate would have been 6.8% if not for drop in participation rate May 2, 2014 2.20pm BST ING's Rob Carnell is also struck by the "extraordinary weakness" of US wage growth .
(12) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(13) The weakness was treated by intensive physical rehabilitation with complete and sustained recovery in all cases.
(14) It also showed weak inhibition of the solid type of Ehrlich carcinoma and prolonged the survival period of mice inoculated with L-1210 cells.
(15) Exposure to whole cigarette smoke from reference cigarettes results in the prompt (peak activity is 6 hrs), but fairly weak (similar to 2 fold), induction of murine pulmonary microsomal monooxygenase activity.
(16) Though the concept of phase, known also as focus, is a very helpful notion, its empirical foundation is yet very weak.
(17) DL 071 IT, a new potent non-selective beta-adrenergic blocking drug with intrinsic sympathomimetic activity and weak membrane stabilizing activity, was evaluated alone and in comparison with oxprenolol, in six volunteers, at rest and during an exercise test.
(18) A variety of weak acids at and below their pK(a) are potent inhibitors of transport in Penicillium chrysogenum.
(19) It added that the crisis had highlighted significant weaknesses in financial regulation, with further measures needed to strengthen supervision.
(20) The radioprotective action in E. coli ATCC 9637 of ascorbate added to media containing the weak sensitizer, tetracycline (effect described by Pittillo and Lucas (1967)), was found to be dependent on the presence of metal catalysts of the autoxidation of ascorbate.