(n.) An inert or slightly active substance used in preparing remedies as a vehicle or medium of administration for the medicinal agents.
Example Sentences:
(1) Poly(ortho ester) bioerodible polymers are suitable materials for the topical administration of a wide variety of therapeutic agents; varying the nature and amounts of excipients physically incorporated into the polymer will vary the erosion rates from a few hours to many months.
(2) Starch particles are the smallest among the excipients studied.
(3) Concentrations of lactose (4.85 and 4.81%), fat (3.76 and 3.67%), total solids (12.57 and 12.44%), SNF (8.83 and 8.75%), casein (2.56 and 2.53%), and true protein (3.13 and 3.08%) were similar in milks from cows receiving bST and excipient, respectively.
(4) The following results were obtained in the treated forearm versus the untreated forearm (excipient alone): clinically, an increase in skin thickness; by noninvasive techniques, an increase in skin thickness, skin elasticity, skin conductance, and TEWL, and a reduction in the size of the corneocytes.
(5) The results show that the choice of the excipients is basic.
(6) safety of HPCD and its well-characterized chemical composition, suggest that this starch derivative may be a potentially useful excipient for protein drugs intended for parenteral use.
(7) However, the observation that dextran 40 formulations showed poor stability toward aggregation demonstrates that an amorphous excipient system is not a sufficient condition for stability.
(8) However, due to crystallization of the excipients during storage and the resulting decrease in Tg, samples stored at 25 degrees C were also above their Tg during much of the storage period.
(9) The effect of intramuscular injections of two multivitamin preparations, two excipient preparations without vitamins, and a placebo preparation (glycine 2.5%) on serum creatine kinase activity (S-CK) in ten healthy volunteers (three female, seven male) aged between 23 and 25 years was investigated.
(10) The method is precise and selective for nitrazepam in the presence of the tablet excipients and 2-amino-5-nitrobenzophenone, the principal hydrolysis product of nitrazepam.
(11) Solid excipients, cornstarch, and talcum powder when injected intra-arterially decreased flow, and vascular obstruction was shown angiographically.
(12) Gluconolactone contributed least to the degradation of the drug as compared to other excipients studied.
(13) Gluconolactone was evaluated as an excipient for tablets prepared by direct compression using various drugs known to be difficult to compress.
(14) Tolerance was excellent except for mild nausea, probably due to the excipients, in two patients taking nine capsules.
(15) The oral provocation test with the excipient of the commercial preparation was negative; the tolerance to Methyl-Digoxin complete.
(16) The best solvents were then used in the study of different semisolid vehicles for topical use (cetylic excipient, Beeler's base and Carbopol gel), which show different physicochemical characteristics.
(17) In contrast, no significant difference in mean survival was observed between excipient and rHTNF treated animals bearing MCA-38, -101, or -102.
(18) Excipient-treated PIC barrows exhibited faster and more efficient growth (P less than .001) and a higher capacity for carcass protein accretion (P less than .001) but similar rates of lipid deposition compared to excipient-treated NEB barrows.
(19) TIMI Phase 1.5 compared two preparations of rt-PA, the early formulation in liquid excipient ("old" rt-PA) and the new lyophilized form ("new" rt-PA).
(20) Canrenone can be determined by high-speed liquid chromatography in pharmaceutical dosage forms without interference from common excipients or degradation products.
Vehicle
Definition:
(n.) That in or on which any person or thing is, or may be, carried, as a coach, carriage, wagon, cart, car, sleigh, bicycle, etc.; a means of conveyance; specifically, a means of conveyance upon land.
(n.) That which is used as the instrument of conveyance or communication; as, matter is the vehicle of energy.
(n.) A substance in which medicine is taken.
(n.) Any liquid with which a pigment is applied, including whatever gum, wax, or glutinous or adhesive substance is combined with it.
Example Sentences:
(1) They broke in with a battering ram: an armoured vehicle known as a Bearcat.
(2) Six of 7 SAO shock rats treated with U74006F survived for 120 min following reperfusion, while none of 7 SAO shock rats given the vehicle survived for 120 min (P less than .01).
(3) It would be "very easy to manipulate and access one of our vehicles", he said.
(4) A group of rats raised on D-P++ for 4 weeks were fed D-P- for 7 days after which they received 500 pmol of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; SUPP] or an equal volume of the vehicle (ETH).
(5) Neonatal treatment with a low dose of the estrogen diethylstilbestrol (DES) had no significant effect on adult estrogen binding within the assayed vaginal compartments; however, this treatment caused a 2-fold increase in the level of cytosolic progestin binding in the vaginal FMW over that in vehicle-treated mice.
(6) Each subject applied a vehicle cream containing 0.075% capsaicin (Axsain, GalenPharma Inc.) to a 4 cm2 area of skin on one volar forearm and vehicle alone to an identical treatment area on the other forearm, according to a double-blind procedure.
(7) Utilizing the bilateral comparison technique in 30 hospitalized patients with chronic stable plaque-type psoriasis vulgaris, we closely monitored the clinical responses to ultraviolet radiation (Westinghouse fluorescent FS40 bulbs, 290--400 nm) and a variety of tar preparations and lubricant vehicles in combination and separately.
(8) Controls were injected in the same manner with vehicle and microspheres.
(9) Sympathetic nervous system function was blocked in developing male SHR by treating pups from days 0 to 14 with: (1) guanethidine, (2) combined alpha- and beta-receptor antagonists (prazosin and timolol), or (3) vehicle (5% sucrose).
(10) The most common seenario was a vehicle-vehicle collision in which seat belts were not used and the decedent or the decedent's driver was at fault.
(11) Thus, the lymphoid population containing cell-mediated anti-idiotypic responsiveness served as a vehicle of resistance.
(12) Well known buyout firms such as Blackstone and Carlyle appear in the leaked documents, and Luxembourg investment vehicles are commonplace in such investment firms.
(13) Future studies will need to carefully evaluate the vehicle used and the strength of topical CsA employed.
(14) The Calspan 3-D Computer Simulator of a Motor Vehicle Crash Victim was used to provide estimates of the head and neck response to be expected for the very specific deceleration profiles simulated.
(15) "There were around 50 attackers, heavily armed in three vehicles, and they were flying the Shebab flag," Maisori added, speaking from the town, where several buildings including hotels, restaurants, banks and government offices were razed to the ground.
(16) Two officers who witnessed the shooting of unarmed 43-year-old Samuel DuBose in Cincinnati will not face criminal charges, despite seemingly corroborating a false claim that DuBose’s vehicle dragged officer Ray Tensing before he was fatally shot.
(17) Vehicle administration had no effect on pulmonary function.
(18) The best was the oral version of the Symbol Digit Modalities test, which by itself accounted for 70% of the variance of the full-sized-vehicle driving score.
(19) II with melatonin instead of 25.9% in the corresponding vehicle controls.
(20) Twenty-four h prior to the measurement of 45Ca2+ uptake, the cells were transferred to serum-free medium ([Ca2+], 1.0 mM) containing 1.0 nM 1,25(OH)2D3 or vehicle.