(a.) Freeing from a burden or obligation; tending to exonerate.
Example Sentences:
(1) We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene.
(2) Therefore, we conclude this is a bovine DR beta-like pseudogene, BoDR beta I. Exon-containing regions have been used as probes in Southern blot analyses of bovine genomic DNA digested with EcoRI.
(3) Exons and flanking introns (greater than 14 kb) were sequenced to determine the structural organization of the gene.
(4) The gene is 20 kilobases (kb) long and has 11 exons, the first and second exons being separated by an intron of 10 kb.
(5) All four human MBP variants were identical except for the insertion of deletion of two peptide fragments corresponding to those encoded by exons 2 and 5 of the MBP gene.
(6) The RB transcript is encoded in 27 exons dispersed over about 200 kilobases (kb) of genomic DNA.
(7) Using a DNA insert encoding exons 2-5, the renin gene was mapped to human chromosome bands 1q25----q32 by in situ hybridization.
(8) Twenty-nine deletion breakpoints were mapped in 220 kb of the DXS164 locus relative to potential exons of the Duchenne and Becker muscular dystrophy gene.
(9) In this type IIB lck transcript, 10 residues encoded by exon 1 from the new AUG codon replace the first 35 residues encoded by exon 1'.
(10) The nucleotide sequence and organization of the human theta 1 gene (exons, introns, promoter, and polyadenylation signals) are similar to those reported for the orangutan theta 1-globin gene.
(11) A comparison between the primary structures of the rat and human genes reveals that the heterogeneity of the C-terminal peptides can be explained in large part by a frameshift mutation and the utilization of an alternative splice donor site in the third exon of the rat gene.
(12) These fragments contain the coding exons for the EBV-determined nuclear antigens EBNA2 and EBNA1, and the membrane antigen LMP, respectively.
(13) This change led to an exon-skipping event resulting in a frame shift and generation of a stop codon.
(14) Amino- and carboxy-terminal information are contained in exons 2 and 7, respectively.
(15) The protein variation potentially includes N-terminal differences coded for by transcript-specific 5' exons and internal differences arising from the optional inclusion of a 39 base-pair exon and from the alternative use of two 3' splice sites separated by six base-pairs.
(16) Moreover, the homozygous mutation appears to cause skipping of exon 6 in the mutant E1 alpha transcript.
(17) DNA sequencing analysis indicated that it was 426 base pairs in size and located in close proximity to a putative c-fms exon.
(18) We infer that a 5' cap is present on both of these RNAs and conclude that the mini-exon-derived RNA donates its 5' cap along with the mini-exon sequence to the pre-mRNA.
(19) Polyadenylated S14 transcripts purified from HeLa cell cytoplasma display heterogeneous 5' ends that map within noncoding RPS14 exon 1.
(20) cDNA was prepared by reverse transcription of peripheral blood mRNA and amplified by the polymerase chain reaction (PCR) using primers corresponding to sequences 400 bp apart on the cDNA, spanning the last three exons (X, Y, Z) of the beta-Sp gene.
Obligation
Definition:
(n.) The act of obligating.
(n.) That which obligates or constrains; the binding power of a promise, contract, oath, or vow, or of law; that which constitutes legal or moral duty.
(n.) Any act by which a person becomes bound to do something to or for anouther, or to forbear something; external duties imposed by law, promise, or contract, by the relations of society, or by courtesy, kindness, etc.
(n.) The state of being obligated or bound; the state of being indebted for an act of favor or kindness; as, to place others under obligations to one.
(n.) A bond with a condition annexed, and a penalty for nonfulfillment. In a larger sense, it is an acknowledgment of a duty to pay a certain sum or do a certain things.
Example Sentences:
(1) However, he has also insisted that North Korea live up to its own commitments, adhere to its international obligations and deal peacefully with its neighbours.
(2) Shorten said any arrangement needed to be consistent with international obligations, with asylum seekers afforded due process and their claims properly assessed.
(3) And this has opened up a loophole for businesses to be morally bankrupt, ignoring the obligations to its workforce because no legal conduct has been established.” Whatever the outcome of the pending lawsuits, it’s unlikely that just one model will work for everybody.
(4) If we’re waiting around for the Democratic version to sail through here, or the Republican version to sail through here, all those victims who are waiting for us to do something will wait for days, months, years, forever and we won’t get anything done.” Senator Bill Nelson, whose home state of Florida is still reeling from the Orlando shooting, said he felt morally obligated to return to his constituents with results.
(5) 45Calcium has been used to compare the kinetics for the transport and bioaccumulation of this regulatory cation in keratinocyte cultures of a kindred with HPS (i.e., one HPS homozygote, one HPS obligate heterozygote, one normal family member, and healthy adult controls).
(6) The department will consider the judgment to see whether it is obliged to rerun the consultation process.
(7) Physicians have an obligation to ensure that parents make a well-considered decision, and to provide them with counsel and support.
(8) As he told us: 'Individual faults and frailties are no excuse to give in and no exemption from the common obligation to give of ourselves.'
(9) Organisms of the genus Bacteroides represent the major group of obligate anaerobes involved in human infections.
(10) Considerations of different ways of obtaining informed consent, determining ways of minimizing harm, and justifications for violating the therapeutic obligation are discussed but found unsatisfactory in many respects.
(11) As commander in chief, I believe that taking care of our veterans and their families is a sacred obligation.
(12) A 20% discount will save the average first-time buyer £43,000 on a £218,000 home (the average cost paid by such buyers), which would leave a revenue shortfall of £8bn from income if current regulatory obligations had been retained on the 200,000 homes.
(13) Justice Hiley later suggested the conduct required by a doctor outside of his profession, as Chapman was describing it, was perhaps a “broad generality” and not specific enough “to create an ethical obligation.” “It’s no broader than the Hippocratic oath,” Chapman said in her reply.
(14) Asked by Marr if he knew if Ashcroft paid tax in this country, Hague said:" I'm sure he fulfils the obligations that were imposed on him at the time he became …" Marr: "Have you asked him?"
(15) These species are all obligately anaerobic, asaccharolytic, and generally nonreactive, and they grow poorly and slowly on media commonly used to isolate anaerobic bacteria.
(16) According to Swedish law, couples who are planning to marry are obliged to publish their address.
(17) In the present report we summarize our data on 144 obligate female carriers.
(18) But whether it arose from religious belief, from a noblesse oblige or from a sense of solidarity, duty in Britain has been, to most people, the foundation of rights rather than their consequence.
(19) No serious side effects were reported and none of the patients was obliged to terminate treatment because of side effects.
(20) This paper argues that although this is true of some types of obligation, including the ones discussed by Professor Kluge, it is by no means true of all.