(n.) A nesting or unfledged bird; in falconry, a young hawk from the nest, not able to prey for itself.
(a.) Unfledged, or newly fledged.
Example Sentences:
(1) This was supported by the fact that Poly EYK(EYA)5 is alpha-helical but the peptides used here showed only a slight propensity to adopt this structure and it did not correlate with their functional activity.
(2) To understand the molecular basis of epitope selection we have analysed the hierarchy of T cell epitopes in a repeating synthetic polypeptide antigen Poly 18, Poly EYK(EYA)5 in the mice of H-2d haplotype.
(3) Animals which are nonresponders to Poly EYA or Poly EFA, when primed with Poly EYAEFA, produce both T cells and antibodies which crossreact with Poly EYA and Poly EFA.
(4) However, we observed the dominance of (EYA)5 reactive clones even when EYK(EYA)3 was used as an immunogen and this could be related to the degeneracy of their antigen specificity.
(5) We investigated the Ia and T cell receptor interaction sites on the synthetic polypeptide antigen poly-18 [poly-EYK(EYA)5] using T cell hybridoma clones specific for this antigen in the context of I-Ad.
(6) We have analyzed the fine specificity of 21 randomly chosen Poly 18-reactive, (EYA)5-specific and H-2d-restricted T cell hybridomas derived from H-2d, H-2bxd, and H-2b----H-2bxd Poly 18-responding mice to determine the number of unique antigen reactivity patterns represented by this T cell population.
(7) In these mice Poly 18 induced good T-cell proliferative response, which was inhibited by anti-Ia antibody, and the mice were able to respond to tyrosine-containing polypeptide Poly EYA but not to the phenylalanine-containing antigen Poly EFA.
(8) Synthetic antigen Poly EYK(EYA)5 induces T cells of narrowly defined fine specificity as represented by the two I-Ad-restricted T cell hybridomas, A.1.1 and B.1.1.
(9) Mice of H-2b,d haplotypes are high responders to Poly EYA, mice of H-2p,q haplotypes are high responders to Poly EFA and mice of H-2b,d,p,q strains are high responders to Poly EYAEFA.
(10) The binding of (EYA)5 to the antigen-binding groove of I-Ad appears to generate a highly diversified T cell response.
(11) (EYA)5 reactive T cell clones appear to be very heterogenous and much larger in number than EYK(EYA)4 reactive clones.
(12) Hybridoma A.1.1 responds to EYK(EYA)4 as the minimum antigenic sequence while hybridoma B.1.1 recognizes (EYA)5 sequence.
(13) By considering, in particular, the kinetic constants obtained with the pentapeptides AAYAA, EEYAA, AEYAA, EAYAA, with the tetrapeptides AYAA and EYAA and with the tripeptides AYA and EYA, it turns out that N-terminal acidic residue(s) are only essential with TPK-IIB for efficient phosphorylation with multiple residues displaying a synergistic effect.
(14) The unusual hierarchy observed for immunodominance in these overlapping epitopes of EYK(EYA)5 sequence suggest a bias in the selection of T cell repertoire based upon the crossreactivity between potential epitopes generated as a result of antigen processing.
(15) The T cell response directed to the repeating tripeptide epitope (EYA)5 is extremely heterogenous even though the epitope has a relatively simple amino acid sequence.
(16) Therefore, (EYA)5-I-Ad complex allows the activation of unrelated T cell clonotypes with the same overall antigen specificity and MHC restriction, but with distinct microheterogeneity in response and receptor usage.
(17) The epitope (EYA)3EYK appears to be subdominant since it can elicit Poly EYK(EYA)5 specific T cells upon immunization but does not appear to be part of Poly EYK(EYA)5 repertoire.
(18) (EYA)5 reactive clones could be elicited by at least three short Poly-18 derived epitopes (EYA)4, EYK(EYA)3 and (EYA)3EYK while EYK(EYA)4 reactive clones elicited only by the EYK(EYA)3 epitope.
(19) Surprisingly, the substituted peptide EYAEAA(EYA)3 could activate A.1.1, indicating that an Ala at position 5 instead of a Tyr obviates the critical requirement for Lys3.
(20) Hen egg lysozyme, pigeon cytochrome C and the synthetic polypeptide Poly 18, Poly EYK(EYA)5 antigen produce good antibody responses.
Fledged
Definition:
(imp. & p. p.) of Fledge
Example Sentences:
(1) It is the only fully-fledged casino to open in the region, outside Lebanon.
(2) The position that it is time for the nursing profession to develop programs leading to the N.D. degree, or professional doctorate, (for the college graduates) derives from consideration of the nature of nursing, the contributions that nurses can make to development of an exemplary health care system, and from the recognized need for nursing to emerge as a full-fledged profession.
(3) I knew absolutely nothing about what to expect when I entered the cinema but within 10 minutes I was a fully fledged convert.
(4) The downgrading in late 2013 of what had been a fully fledged A&E unit at Chase Farm to an urgent care centre, despite a huge campaign of opposition, led to a 20% increase in the number of sick people seeking treatment at the North Middlesex.
(5) Furthermore, feminism requires new forms of social interaction that embody the esthetical space women need to experience life as full-fledged citizens.
(6) On the Colville River in northwestern Alaska, the last young falcons will fledge in 1975 and the remaining adult population will disappear by 1980 unless the present rate of reproductive failure is drastically and quickly reversed.
(7) On the other hand the Scots voted by a two to one majority and were rewarded with a fully-fledged parliament.
(8) Fortunately for her and her readers, this voice arrived fully fledged, and proved to be remarkably reliable.
(9) This year, heading into 2016, they are becoming fully fledged substitutes for campaigns, taking over functions including opposition research, polling and even knocking on doors.
(10) Breeding success was measured as a function of eggs hatched and chicks fledged.
(11) A fledging ratio is used to support the hypothesis that maternal prezygotic exposure affects the viability of embryos and chicks.
(12) The author concludes that C-L psychiatry has achieved the status of a full-fledged subspecialty of psychiatry, one whose main contribution has been to draw attention of clinicians and researchers to psychosocial aspects of physical illness, and to the psychiatric complications of such illness and of the medical and surgical therapies.
(13) Other Hamas officials said only a fully fledged deal to end hostilities would be accepted.
(14) The armistice never became a fully-fledged peace agreement and therefore North and South Korea technically remain at war.
(15) Full-fledged allergic bronchopulmonary aspergillosis (ABPA) has been estimated to occur in 10% of patients with CF.
(16) The most significant difference from last year's London event is that instead of a tottering and discredited transitional regime, Somalia now has a fully fledged government, led by Hassan Sheikh Mohamud.
(17) Kindle Fire, the fully fledged tablet computer Amazon first released in 2011, sold 9m units last year.
(18) Homelessness, that most visceral signifier of hard times, is on the rise and shaping up to be not merely another policy embarrassment for the coalition, but a fully fledged social crisis.
(19) Nursing is the agent of change for moving health care from a cottage industry to a full-fledged business enterprise--a business with compassion, empathy, and quality.
(20) In a speech in Manchester, Trevor Phillips, the head of the Commission for Racial Equality, will warn against the country "sleep-walking" into a "New Orleans-style" quagmire of "fully fledged ghettoes".