(n.) A nesting or unfledged bird; in falconry, a young hawk from the nest, not able to prey for itself.
(a.) Unfledged, or newly fledged.
Example Sentences:
(1) This was supported by the fact that Poly EYK(EYA)5 is alpha-helical but the peptides used here showed only a slight propensity to adopt this structure and it did not correlate with their functional activity.
(2) To understand the molecular basis of epitope selection we have analysed the hierarchy of T cell epitopes in a repeating synthetic polypeptide antigen Poly 18, Poly EYK(EYA)5 in the mice of H-2d haplotype.
(3) Animals which are nonresponders to Poly EYA or Poly EFA, when primed with Poly EYAEFA, produce both T cells and antibodies which crossreact with Poly EYA and Poly EFA.
(4) However, we observed the dominance of (EYA)5 reactive clones even when EYK(EYA)3 was used as an immunogen and this could be related to the degeneracy of their antigen specificity.
(5) We investigated the Ia and T cell receptor interaction sites on the synthetic polypeptide antigen poly-18 [poly-EYK(EYA)5] using T cell hybridoma clones specific for this antigen in the context of I-Ad.
(6) We have analyzed the fine specificity of 21 randomly chosen Poly 18-reactive, (EYA)5-specific and H-2d-restricted T cell hybridomas derived from H-2d, H-2bxd, and H-2b----H-2bxd Poly 18-responding mice to determine the number of unique antigen reactivity patterns represented by this T cell population.
(7) In these mice Poly 18 induced good T-cell proliferative response, which was inhibited by anti-Ia antibody, and the mice were able to respond to tyrosine-containing polypeptide Poly EYA but not to the phenylalanine-containing antigen Poly EFA.
(8) Synthetic antigen Poly EYK(EYA)5 induces T cells of narrowly defined fine specificity as represented by the two I-Ad-restricted T cell hybridomas, A.1.1 and B.1.1.
(9) Mice of H-2b,d haplotypes are high responders to Poly EYA, mice of H-2p,q haplotypes are high responders to Poly EFA and mice of H-2b,d,p,q strains are high responders to Poly EYAEFA.
(10) The binding of (EYA)5 to the antigen-binding groove of I-Ad appears to generate a highly diversified T cell response.
(11) (EYA)5 reactive T cell clones appear to be very heterogenous and much larger in number than EYK(EYA)4 reactive clones.
(12) Hybridoma A.1.1 responds to EYK(EYA)4 as the minimum antigenic sequence while hybridoma B.1.1 recognizes (EYA)5 sequence.
(13) By considering, in particular, the kinetic constants obtained with the pentapeptides AAYAA, EEYAA, AEYAA, EAYAA, with the tetrapeptides AYAA and EYAA and with the tripeptides AYA and EYA, it turns out that N-terminal acidic residue(s) are only essential with TPK-IIB for efficient phosphorylation with multiple residues displaying a synergistic effect.
(14) The unusual hierarchy observed for immunodominance in these overlapping epitopes of EYK(EYA)5 sequence suggest a bias in the selection of T cell repertoire based upon the crossreactivity between potential epitopes generated as a result of antigen processing.
(15) The T cell response directed to the repeating tripeptide epitope (EYA)5 is extremely heterogenous even though the epitope has a relatively simple amino acid sequence.
(16) Therefore, (EYA)5-I-Ad complex allows the activation of unrelated T cell clonotypes with the same overall antigen specificity and MHC restriction, but with distinct microheterogeneity in response and receptor usage.
(17) The epitope (EYA)3EYK appears to be subdominant since it can elicit Poly EYK(EYA)5 specific T cells upon immunization but does not appear to be part of Poly EYK(EYA)5 repertoire.
(18) (EYA)5 reactive clones could be elicited by at least three short Poly-18 derived epitopes (EYA)4, EYK(EYA)3 and (EYA)3EYK while EYK(EYA)4 reactive clones elicited only by the EYK(EYA)3 epitope.
(19) Surprisingly, the substituted peptide EYAEAA(EYA)3 could activate A.1.1, indicating that an Ala at position 5 instead of a Tyr obviates the critical requirement for Lys3.
(20) Hen egg lysozyme, pigeon cytochrome C and the synthetic polypeptide Poly 18, Poly EYK(EYA)5 antigen produce good antibody responses.
Nias
Definition:
(n.) A young hawk; an eyas; hence, an unsophisticated person.
Example Sentences:
(1) The NIa-like protein of plum pox virus is a protease with high sequence specificity that is autocatalytically released from the viral polyprotein.
(2) Development and present stand of treatment of NIA are described.
(3) NCIB 11015, Achromobacter xylosoxidans GIFU 543); II, denitrifying bacteria in which cytochrome c' has not been found (Alcaligenes faecalis IAM 1015, Bacillus firmus NIAS 237, Pseudomonas stutzeri ATCC 17641); III, non-denitrifying bacterium containing cytochrome c' (A. xylosoxidans GIFU 1055).
(4) These results were consistent for NIa protein sequences placed at a foreign TEV cleavage site or in unrelated proteins.
(5) Positive results were correlated with the occurrence of neonatal isohemolytic anemia (NIA) in calves and were used to predict the occurrence of NIA.
(6) Two domains within NIa, one between amino acid residues 1 to 11 (signal domain I) and the other between residues 43 to 72 (signal domain II), were found to function additively for efficient localization of fusion proteins to the nucleus, although either region independently could facilitate a low level of translocation.
(7) Virions expressing the pgI also emerged after serial in vitro passages of the wild-type PRV strain NIA-5 which initially expressed wild-type pgI.
(8) The proteolytic activities at different cleavage sites of several deletion and point mutations of NIa protein have been analysed.
(9) Tour begins 22 November, NIA, Birmingham, thenia.co.uk Black Sabbath Still without original drummer Bill Ward, but with their first US No 1 album (the Rick Rubin-produced 13), the undisputed godfathers of metal play a handful of UK shows.
(10) GL-AIa reacted strongly with beta-glucosyl-Yariv antigen, GL-NIa reacted weakly, whereas GL-NIb and GL-AIb showed no reaction with the antigen.
(11) Intermediate virulent virus 2.4N3A, a mutant strain derived from NIA-3, caused less necrosis of the mucosa and did not reach axons of olfactory nerves until 72 h after inoculation.
(12) Zone C has been defined as the cortical region projecting to the nucleus interpositus anterior (NIA) and posterior (NIP).
(13) The use of probes which permitted translation through as few as 15 nucleotide residues beyond the sequences encoding the proposed carboxyl terminus of NIa resulted in normal processing.
(14) Among various nitrate reductase-deficient mutants, an apoprotein gene mutant (nia.
(15) The unique short (Us) region of the pseudorabies virus (PRV) genome, which displays high transcriptional activity during the late phase of infection and has been found to code for glycoproteins, is partially deleted in the genomes of three vaccine strains (A57, Norden, and NIA-4).
(16) The remaining 80% of the administered dose of NIA or NAM disappeared from rumen liquor without being washed out.
(17) Precipitation of 125I-labeled VPg with anti-tobacco etch virus 49K nuclear inclusion protein antiserum (which reacts with the NIa nuclear inclusion protein of TVMV) indicated that the TVMV VPg is immunologically related to NIa.
(18) But one might have imagined Corbyn would have used the opportunity to send one of the really big power players of the new shadow cabinet – his transport spokeswoman Lilian Greenwood, say, or Nia Griffith, who has the Wales portfolio – rather than his lowly shadow chancellor.
(19) The hindlimb region of RNm receives input from anteriomedial NIA and medial NIP.
(20) To investigate nocturnal leg movement activity and other polysomnographic features in patients with neuroleptic-induced akathisia (NIA), all-night polysomnography was performed in nine patients with NIA and compared with nine healthy individuals and eight unmedicated patients with depression.