(n.) A nesting or unfledged bird; in falconry, a young hawk from the nest, not able to prey for itself.
(a.) Unfledged, or newly fledged.
Example Sentences:
(1) This was supported by the fact that Poly EYK(EYA)5 is alpha-helical but the peptides used here showed only a slight propensity to adopt this structure and it did not correlate with their functional activity.
(2) To understand the molecular basis of epitope selection we have analysed the hierarchy of T cell epitopes in a repeating synthetic polypeptide antigen Poly 18, Poly EYK(EYA)5 in the mice of H-2d haplotype.
(3) Animals which are nonresponders to Poly EYA or Poly EFA, when primed with Poly EYAEFA, produce both T cells and antibodies which crossreact with Poly EYA and Poly EFA.
(4) However, we observed the dominance of (EYA)5 reactive clones even when EYK(EYA)3 was used as an immunogen and this could be related to the degeneracy of their antigen specificity.
(5) We investigated the Ia and T cell receptor interaction sites on the synthetic polypeptide antigen poly-18 [poly-EYK(EYA)5] using T cell hybridoma clones specific for this antigen in the context of I-Ad.
(6) We have analyzed the fine specificity of 21 randomly chosen Poly 18-reactive, (EYA)5-specific and H-2d-restricted T cell hybridomas derived from H-2d, H-2bxd, and H-2b----H-2bxd Poly 18-responding mice to determine the number of unique antigen reactivity patterns represented by this T cell population.
(7) In these mice Poly 18 induced good T-cell proliferative response, which was inhibited by anti-Ia antibody, and the mice were able to respond to tyrosine-containing polypeptide Poly EYA but not to the phenylalanine-containing antigen Poly EFA.
(8) Synthetic antigen Poly EYK(EYA)5 induces T cells of narrowly defined fine specificity as represented by the two I-Ad-restricted T cell hybridomas, A.1.1 and B.1.1.
(9) Mice of H-2b,d haplotypes are high responders to Poly EYA, mice of H-2p,q haplotypes are high responders to Poly EFA and mice of H-2b,d,p,q strains are high responders to Poly EYAEFA.
(10) The binding of (EYA)5 to the antigen-binding groove of I-Ad appears to generate a highly diversified T cell response.
(11) (EYA)5 reactive T cell clones appear to be very heterogenous and much larger in number than EYK(EYA)4 reactive clones.
(12) Hybridoma A.1.1 responds to EYK(EYA)4 as the minimum antigenic sequence while hybridoma B.1.1 recognizes (EYA)5 sequence.
(13) By considering, in particular, the kinetic constants obtained with the pentapeptides AAYAA, EEYAA, AEYAA, EAYAA, with the tetrapeptides AYAA and EYAA and with the tripeptides AYA and EYA, it turns out that N-terminal acidic residue(s) are only essential with TPK-IIB for efficient phosphorylation with multiple residues displaying a synergistic effect.
(14) The unusual hierarchy observed for immunodominance in these overlapping epitopes of EYK(EYA)5 sequence suggest a bias in the selection of T cell repertoire based upon the crossreactivity between potential epitopes generated as a result of antigen processing.
(15) The T cell response directed to the repeating tripeptide epitope (EYA)5 is extremely heterogenous even though the epitope has a relatively simple amino acid sequence.
(16) Therefore, (EYA)5-I-Ad complex allows the activation of unrelated T cell clonotypes with the same overall antigen specificity and MHC restriction, but with distinct microheterogeneity in response and receptor usage.
(17) The epitope (EYA)3EYK appears to be subdominant since it can elicit Poly EYK(EYA)5 specific T cells upon immunization but does not appear to be part of Poly EYK(EYA)5 repertoire.
(18) (EYA)5 reactive clones could be elicited by at least three short Poly-18 derived epitopes (EYA)4, EYK(EYA)3 and (EYA)3EYK while EYK(EYA)4 reactive clones elicited only by the EYK(EYA)3 epitope.
(19) Surprisingly, the substituted peptide EYAEAA(EYA)3 could activate A.1.1, indicating that an Ala at position 5 instead of a Tyr obviates the critical requirement for Lys3.
(20) Hen egg lysozyme, pigeon cytochrome C and the synthetic polypeptide Poly 18, Poly EYK(EYA)5 antigen produce good antibody responses.
Nyas
Definition:
(n.) See Nias.
Example Sentences:
(1) Mice from our Nya:NYLAR colony were parabiosed using the skin-to-skin or coelomic method, and more than 150 such pairs survived for periods greater than 1 mo.
(2) The found Mg and Nya frequency is comparable to that in the world but is significantly lower than in Switzerland and Norway, respectively; the frequency of antigens Sc 2 and Wra in Czechoslovakia is generally significantly lower.
(3) White mice of the NYA: NYLAR strain were infected with coxsackie B1 or B4 virus and studied for persistence of virus, antibody conversion, histologic changes, and glucose tolerance during periods up to 13 months.
(4) Nya:NYLAR albino mice infected with Toxoplasma gondii gradually developed a chronic and progressive wasting syndrome characterized by facial and body alopecia, corneal opacities, necrotic lesions of ears and tail, signs of neurologic disease and death within six to eight months after infection.
(5) The oldest pair at this writing survived for 27 mo after parabiosis, which is equivalent to the normal life span of the Nya:NYLAR mouse.
(6) The histocompatibility status of the Nya:NYLAR mouse colony was studied by exchange of skin grafts between female mice.
(7) In randomly selected thousands-sized samples of the Central Slovakian population the following proportions of antigen (antibody) positivity were found: 0% for Mg (0.158% for anti-Mg), 0% for Nya (0.008% for anti-Nya), 0.284% for Sc 2 (0% for anti-Sc 2) and 0% for Wra (0.035% for anti-Wra).