(1) Membranes of this material were filled with islets of Langerhans and implanted in the peritoneal cavity of rats.
(2) After either 5 or 10 days of culture with both cytokines, intense immunofluorescent staining for Ia could be identified on the surface of greater than 80-90% of the viable islet cells.
(3) High mortality, severe destruction of pancreatic B-cells and presence of sporadic mononuclear infiltrations in islets and around excretory ducts were observed.
(4) These and other results suggest that the experimental agents do not provide protection against alloxan inhibition by preventing the entry of alloxan into the intracellular space of the islet.
(5) In attempts to correlate GLUT-1 and GLUT-2 expression to beta-cell function glucose uptake and glucose-stimulated insulin release in fresh and cultured islets were measured.
(6) It is suggested that PDGF is of importance for fetal islet development.
(7) LFD animals (n = 12) do not show any morphometric changes in comparison with LED controls; but macronesia, micronesia and polynesia of islets were observed.
(8) It is concluded that extracellularly generated free radicals induce damage to the plasma membrane of islet cells.
(9) Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000.
(10) Both substances decreased the concentrations of NAD(+) in the islet cells to about 10% of the control values within 2h after injection.
(11) Grouped islets treated with actinomycin D and cycloheximide did not exhibit aggregation when incubated with these inhibitors.
(12) Although the islet promoter was found to lack a TATA box, a major transcript from the islet promoter was mapped 486 nucleotides upstream of the translation initiation site.
(13) Six days later, the islets exposed to heat shock showed a lower DNA content, indicating islet cell death.
(14) The results show that the difference in insulin secretory response between islets from normal and pregnant rats may be preserved when the islets are cultured for 20 h, and that these differences are enhanced for a variety of reasons after culture of islets in 83.3 mM glucose.
(15) The hamster islet B cell line HIT retains the ability to secret insulin in response to glucose and several receptor agonists.
(16) On the other hand, the islets in the duodenal lobe were small in size compared with the other 3 regions, and were predominant in insulin and pancreatic polypeptide (PP) cells, but almost lacked in glucagon cells.
(17) These new observations provide insight into the complex nature of GABAergic neurons and beta-cell GABA in regulation of islet function.
(18) Prior treatment with MMSucc in the presence of 2.75 mM glucose sensitized islets to the usually weak insulin secretory effect of 7.5 mM glucose.
(19) The glucose 6-phosphate content of intact islets is higher in the presence of beta- than alpha-D-glucose.
(20) Pancreatic islet cell tumors were induced in 32 of 49 male Wistar rats (73%) surviving 9 months or longer following treatment with streptozotocin alone, with streptozotocin and nicotinamide, or with streptozotocin and picolinamide.