(1) Structure assignment of the isomeric immonium ions 5 and 6, generated via FAB from N-isobutyl glycine and N-methyl valine, can be achieved by their collision induced dissociation characteristics.
(2) Polyribosomes isolated from the livers of rats sacrificed 6 h after treatment with actinomycin D showed a 42% reduction in their capacity to bind anti-RSA Fab'.
(3) The combined amounts of S-1 and Fab binding to actin suggested that the activation of the myosin ATPase activity was due to actin free of Fab.
(4) Brief digestion at neutral pH without reduction produced a molecule in which the Fab and Fc fragments were still linked by a pair of labile disulphide bridges, and the Fc fragment released by cleaving these bonds, called 1Fc fragment, contained a portion of the ;hinge' region including an interchain disulphide bridge.
(5) Initial analysis of aspirated bone marrow disclosed ALL FAB-L1 morphology, common (Ia+, cALLa+) immunophenotype and a complex abnormal karyotype.
(6) An isotopic double-labeling technique was developed that demonstrated that the 603 crystals bind 1 mol of hapten per mol of Fab-fragment, but with a binding constant significantly lower than that observed in solution.
(7) Its autoimmune nature is probable although we failed to demonstrate any inhibitory effect of Fab obtained from the patient's purified IgM.
(8) The use of Fab fragments in conjunction with Fab-specific secondary and tertiary antisera improved tissue penetration and made it possible to identify a number of the immunoreactive neurons.
(9) We present here a case of acute monocytic leukemia (AMoL, FAB M5b) with four copies of chromosome #8.
(10) The superprecipitation activity of Fab-myosin was also highly dependent on phosphorylation of the light chains.
(11) The FAB-MS was used in conjunction with carboxypeptidase Y digestion and results indicated that this procedure proved to be a powerful tool for rapid sequence determination.
(12) Fab fragment half times were only 0.31 and 5.4 h, with 9% remaining intravascularly.
(14) The affinity-purified rabbit anti-human chorionic gonadotropin Fab'-beta-D-galactosidase conjugate was separated from non-specific goat Fab'-beta-D-galactosidase conjugate and unconjugated beta-D-galactosidase by affinity chromatography on a column of goat (anti-rabbit IgG) IgG-Sepharose 4B using 4 M urea.
(15) At 37 degrees C, heparin-releasable binding of LDL and binding of Fab fragments were double that at 4 degrees C, whereas binding of antibody remained unchanged.
(16) An infertile 37-year-old woman was diagnosed as having acute monocytic leukemia (AMoL) (FAB classification; M5b).
(17) 5-10%), according to analysis by high-performance liquid chromatography (HPLC) and fast atom bombardment mass spectrometry (FAB-MS).
(18) The Fab fragments contained neutral, monosialylated, and disialylated oligosaccharides, whereas the Fc fragment contained only neutral and monosialylated structures.
(19) IgM antibody levels against both whole IgA and Fab of IgA were significantly higher than IgG antibody levels.
(20) CD11b was uniformly weakly expressed by all FAB subgroups.
Fap
Definition:
(a.) Fuddled.
Example Sentences:
(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.