(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Fat
Definition:
(n.) A large tub, cistern, or vessel; a vat.
(n.) A measure of quantity, differing for different commodities.
(superl.) Abounding with fat
(superl.) Fleshy; characterized by fatness; plump; corpulent; not lean; as, a fat man; a fat ox.
(superl.) Oily; greasy; unctuous; rich; -- said of food.
(superl.) Exhibiting the qualities of a fat animal; coarse; heavy; gross; dull; stupid.
(superl.) Fertile; productive; as, a fat soil; a fat pasture.
(superl.) Rich; producing a large income; desirable; as, a fat benefice; a fat office; a fat job.
(superl.) Abounding in riches; affluent; fortunate.
(superl.) Of a character which enables the compositor to make large wages; -- said of matter containing blank, cuts, or many leads, etc.; as, a fat take; a fat page.
(n.) An oily liquid or greasy substance making up the main bulk of the adipose tissue of animals, and widely distributed in the seeds of plants. See Adipose tissue, under Adipose.
(n.) The best or richest productions; the best part; as, to live on the fat of the land.
(n.) Work. containing much blank, or its equivalent, and, therefore, profitable to the compositor.
(a.) To make fat; to fatten; to make plump and fleshy with abundant food; as, to fat fowls or sheep.
(v. i.) To grow fat, plump, and fleshy.
Example Sentences:
(1) This effect was more marked in breast cancer patients which may explain our earlier finding that women with upper body fat localization are at increased risk for developing breast cancer.
(2) After a period on fat-rich diet the patient's physical fitness was increased and the recovery period after the acute load was shorter.
(3) In the clinical trials in which there was complete substitution of fat-modified ruminant foods for conventional ruminant products the fall in serum cholesterol was approximately 10%.
(4) To estimate the age of onset of these differences, and to assess their relationship to abdominal and gluteal adipocyte size, we measured adiposity, adipocyte size, and glucose and insulin concentrations during a glucose tolerance test in lean (less than 20% body fat), prepubertal children from each race.
(5) High radioactivities were observed in the digestive organs, mesenteric lymphnodes, liver, pancreas, urinary bladder, fat tissue, kidney and spleen after oral administration to rats.
(6) There were few significant differences between high polyunsaturated (safflower oil) and saturated fat (lard) diet groups.
(7) Protein composition was determined in mesenteric lymph chylomicrons from fat-fed rats.
(8) The relationship of weight history with current fat distribution was also explored.
(9) The heterogeneity of obesity may be demonstrated by the shape of fat distribution and the prolactin response to insulin hypoglycaemia.
(10) Dietary factors affect intestinal P450s markedly--iron restriction rapidly decreased intestinal P450 to beneath detectable values; selenium deficiency acted similarly but was less effective; Brussels sprouts increased intestinal AHH activity 9.8-fold, ECOD activity 3.2-fold, and P450 1.9-fold; fried meat and dietary fat significantly increased intestinal EROD activity; a vitamin A-deficient diet increased, and a vitamin A-rich diet decreased intestinal P450 activities; and excess cholesterol in the diet increased intestinal P450 activity.
(11) I usually use them as a rag with which to clean the toilet but I didn’t have anything else to wear today because I’m so fat.” While this exchange will sound baffling to outsiders, to Brits it actually sounds like this: “You like my dress?
(12) Assuming 1 kg LBM to contain 52.1 mmol potassium, the mean LBM was 3028 g in the I-NSM and 2739 in the I-SM; mean fat mass was similar in both groups.
(13) Cholestyramine resin was beneficial in reducing stool bulk but had no substantial effect on fat absorption.
(14) This study examined the association between diet composition, particularly dietary fat intake, and body-fat percentage in 205 adult females.
(15) With both approaches, carbohydrate and fat had little influence whereas egg albumin had a significant inhibitory effect on the absorption of nonheme iron.
(16) Computed Tomography was used to demonstrate the increased retro-orbital fat.
(17) The results obtained on fat cell membranes from abdominal subcutaneous adipose tissue demonstrated the following.
(18) The latter appears to reflect methodological problems since both fat-free determinations depend upon TBW rather than somatic proteins.
(19) There were no relationships between blood pressure and calorie-adjusted intakes of fats, carbohydrates, sodium, potassium, calcium or magnesium.
(20) As with alloplastic orbital implant extrusions in enucleated sockets, autogeneous dermis fat grafts can be useful in managing extrusions in previously eviscerated sockets.