(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Fay
Definition:
(n.) A fairy; an elf.
(n.) Faith; as, by my fay.
(v. t.) To fit; to join; to unite closely, as two pieces of wood, so as to make the surface fit together.
(v. i.) To lie close together; to fit; to fadge; -- often with in, into, with, or together.
Example Sentences:
(1) The GMB had contacts with him via Fulham football club; 'Pal Fayed', the local paper, the Rhondda Leader, called him on their front page.
(2) Cas Anvar is Dodi Fayed, the billionaire boyfriend who died with Diana in a car crash in Paris on 31 August 1997.
(3) Fay Ballard, daughter of the writer JG Ballard , is describing what happened when her mother, Mary, died of pneumonia, aged 34, on a family holiday in Alicante, Spain.
(4) With Redknapp's and Mandaric's trial now over, it can be revealed that as a result of Operation Apprentice, Storrie was prosecuted, charged with cheating the public revenue in relation to the alleged payment to Faye, and that he and Mandaric were also tried for tax evasion over an alleged termination fee paid to the midfielder Eyal Berkovic via a company, Medellin Enterprises, registered in the British Virgin Islands.
(5) Tony Pulis came down on the side of boldness, recalling Abdou Faye and Andy Wilkinson in defence after suspension in the strongest available line-up.
(6) 1986 Tory MP Tim Smith begins taking cash in brown envelopes from Fayed in return for asking Commons questions and other parliamentary activities.
(7) Fay Ballard in her garden with a sculpture JG Ballard made in the early 1960s.
(8) Conspiracy theories, many put forward by Mohamed Al Fayed, former Harrods owner and father of Dodi Fayed , Diana's companion at the time, who was also killed in the crash on 31 August 1997, were demolished in the course of the much-delayed inquest, held in the high court between October 2007 and April 2008.
(9) To all involved – including our presenters Warren Beatty and Faye Dunaway, the film-makers, and our fans watching worldwide – we apologise.” The Academy said it spent Sunday night and the following day “investigating the circumstances” to “determine what actions are appropriate going forward”.
(10) With his dying breath, Fred Ery identified Floyd "Buzz" Fay as his murderer.
(11) We previously showed that in pupae of Hyalophora cecropia, eight hemolymph proteins (P1 through P8) were selectively synthetized after immunization (Faye et al., Infect, Immun.
(12) "When I reached the age of 34, that was a milestone," says Fay.
(13) Reporter Fay Schlesinger tweeted : "James Harding's departure is a massive loss for us.
(14) Sutherland and Johnson both agreed the picture was Austen; Le Faye did not.
(15) Harrods was sold by Mohammed Al Fayed in 2010 to an investment trust of the Qatari royal family for a reported £1.5bn .
(16) Though it's clear that this was a traumatic experience for Ballard, Fay says that he actually quite liked being in Lunghua camp and based his novel Empire of the Sun on that time.
(17) Peter Barlow's son, Our Simon, is particularly irksome, and Faye, who has been used to address the issue of bullying, has it coming.
(18) "I remember taking it for granted that there would be whisky on his study table at 9am," says Fay.
(19) In his last high profile victory, a year ago, he successfully defended the Harrods owner Mohammed Al Fayed, who was sued by Neil Hamilton over allegations that the former Tory MP took cash for asking parliamentary questions.
(20) Atypical facial pain was first described by Temple Fay in 1927 as a vascular syndrome of dull, throbbing pain situated deep in the eye and malar region often referred toward the ear, lateral neck, and shoulders.