(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Flap
Definition:
(n.) To beat with a flap; to strike.
(v.) Anything broad and limber that hangs loose, or that is attached by one side or end and is easily moved; as, the flap of a garment.
(v.) A hinged leaf, as of a table or shutter.
(v.) The motion of anything broad and loose, or a stroke or sound made with it; as, the flap of a sail or of a wing.
(v.) A disease in the lips of horses.
(n.) To move, as something broad and flaplike; as, to flap the wings; to let fall, as the brim of a hat.
(v. i.) To move as do wings, or as something broad or loose; to fly with wings beating the air.
(v. i.) To fall and hang like a flap, as the brim of a hat, or other broad thing.
Example Sentences:
(1) 14 patients with painful neuroma, skin hyperesthesia or neuralgic rest pain were followed up (mean 20 months) after excision of skin and scar, neurolysis and coverage with pedicled or free flaps.
(2) A distally based posterior tibial artery adipofascial flap with skin graft was used for the reconstruction of soft tissue defects over the Achilles tendon in three cases and over the heel in three cases.
(3) Our results show that stenosis of about one-third of the original external diameter of the artery and vein of the pedicle in our model did not have any significant influence on the survival of the flap and ligation of the femoral artery distal to the branch to the flap did not produce any statistical difference in the viability of the flap.
(4) The haemodynamics and affecting factors of the acute random skin flap and the methods for monitoring its viability were studied.
(5) The general tendency of gradual CBF reduction from the pedicle to the distal end of all the flaps was observed.
(6) This report adds another modification of the standard gastrocnemius muscle flap: transtibial transposition of the muscle through the posterior cortex.
(7) The immediate reconstruction either by local flaps or by free grafts.
(8) Linton flap operation was performed in 202 patients with postphlebitic syndrome complicated by evident ulceration 64% of patients were followed up for 1-14 years.
(9) It was treated by the method of free autogenous gingival graft on the labial side and gingivectomy by flap on the palatal side.
(10) Osteocutaneous flaps from the foot are being utilized more for thumb and digit reconstruction.
(11) The difference from the Hughes flap is that the blood supply is maintained through two tubed pedicles of conjunctiva and Muller's muscle, rather than an apron of conjunctiva.
(12) These observations lead to the hypothesis that acidosis quenches fluorescence in distal skin flaps.
(13) The most common complications in breast augmentation surgery with homologous fat grafts obtained from fresh cadavers are presented, showing subsequent surgical procedures to reconstruct the breasts of such patients through use of silicone prostheses and muscle flaps from the latissimus dorsi.
(14) Both acquired defects were covered by two different cross-finger flap techniques, despite extensive scarring of the adjacent finger.
(15) Based on a limited experience we have found that triangular flap ureteroplasty is a worthwhile means of repeat reimplantation of the obstructed ureter and perhaps provides a better alternative than transureteroureterostomy.
(16) Is there not enough material available, can neck-, breast-or forehead flaps cover the defect, although they do not fulfill the demands for a satisfactory restoration of specific function.
(17) We present our initial experience with a new method of increasing the survival of acute skin flaps through stress conditioning using heat shock and recovery.
(18) We conclude that although the tissue expansion technique yields acceptable results, the TRAM flap yields superior aesthetic results in terms of both appearance and consistency.
(19) The usual approach to the inferior orbit has been through a subciliary skin incision and dissection of a skin flap to the orbital rim.
(20) Exteriorization is accomplished by mobilizing 2 lateral skin flaps from the perineum and joining them with the inverted U flap to reach the vagina.