(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Lap
Definition:
(n.) The loose part of a coat; the lower part of a garment that plays loosely; a skirt; an apron.
(n.) An edge; a border; a hem, as of cloth.
(n.) The part of the clothing that lies on the knees or thighs when one sits down; that part of the person thus covered; figuratively, a place of rearing and fostering; as, to be reared in the lap of luxury.
(n.) That part of any substance or fixture which extends over, or lies upon, or by the side of, a part of another; as, the lap of a board; also, the measure of such extension over or upon another thing.
(n.) The amount by which a slide valve at its half stroke overlaps a port in the seat, being equal to the distance the valve must move from its mid stroke position in order to begin to open the port. Used alone, lap refers to outside lap. See Outside lap (below).
(n.) The state or condition of being in part extended over or by the side of something else; or the extent of the overlapping; as, the second boat got a lap of half its length on the leader.
(n.) One circuit around a race track, esp. when the distance is a small fraction of a mile; as, to run twenty laps; to win by three laps. See Lap, to fold, 2.
(n.) In card playing and other games, the points won in excess of the number necessary to complete a game; -- so called when they are counted in the score of the following game.
(n.) A sheet, layer, or bat, of cotton fiber prepared for the carding machine.
(n.) A piece of brass, lead, or other soft metal, used to hold a cutting or polishing powder in cutting glass, gems, and the like, or in polishing cutlery, etc. It is usually in the form of wheel or disk, which revolves on a vertical axis.
(v. t.) To rest or recline in a lap, or as in a lap.
(v. t.) To cut or polish with a lap, as glass, gems, cutlery, etc. See 1st Lap, 10.
(n.) To fold; to bend and lay over or on something; as, to lap a piece of cloth.
(n.) To wrap or wind around something.
(n.) To infold; to hold as in one's lap; to cherish.
(n.) To lay or place over anything so as to partly or wholly cover it; as, to lap one shingle over another; to lay together one partly over another; as, to lap weather-boards; also, to be partly over, or by the side of (something); as, the hinder boat lapped the foremost one.
(n.) To lay together one over another, as fleeces or slivers for further working.
(v. i.) To be turned or folded; to lie partly upon or by the side of something, or of one another; as, the cloth laps back; the boats lap; the edges lap.
(v. i.) To take up drink or food with the tongue; to drink or feed by licking up something.
(v. i.) To make a sound like that produced by taking up drink with the tongue.
(v. t.) To take into the mouth with the tongue; to lick up with a quick motion of the tongue.
(n.) The act of lapping with, or as with, the tongue; as, to take anything into the mouth with a lap.
(n.) The sound of lapping.
Example Sentences:
(1) On the other hand, the LAP level, identical in preterms and SDB, is lower than in full-term infants but higher than in adults.
(2) We conclude that plasma LAP measurements have little value in monitoring ovulation induction therapy.
(3) A light rain pattered the rooftops of Los Mochis in Friday’s pre-dawn darkness, the town silent and still as the Sea of Cortez lapped its shore.
(4) Experimentally induced tongue contact with a variety of solid surfaces during lapping (an activity involving accumulation of a liquid bolus in the valleculae) induced neither increased jaw opening nor the additional EMG pattern.
(5) Kester said her daughter came and cried in her lap.
(6) 1.08pm BST Lap 2: Sergio Perez is out after an incident at Mirabeau, which is what brought out the yellow flags and safety car.
(7) By comparing P-LAP activity with cystine aminopeptidase activity, we concluded that both activities were shared by the same molecule.
(8) 1.57pm BST Lap 36: Punchy stuff from Jules Bianchi up to 13th, literally bumping his way through Kobayashi on the inside.
(9) The new tablet models come with a better built-in kickstand with two positions rather than one, so they can rest more firmly on users' laps.
(10) After Manchester United came the long goodbye to Stamford Bridge, a home game against Leeds on 15 May 2004, Abramovich's dismissal notice in Ranieri's pocket, but a lap and guard of honour with the players.
(11) Having personally witnessed their live act (Black Flag frantically twanging Bootsy’s Rubber Band) at Dingwalls in late August, I thought I’d made a great discovery until, two breathless days later, and a mere few hours before they left these fair isles, the Peppers deposited their press kit in my lap.
(12) Analysis of the activity of each unit was made at intervals from the beginning of the conditioned signal (light or sound) to the beginning of lapping milk which appeared in the feeding trough after the cat pressed the pedal.
(13) (2) The alleles at the Est-1, Est-2, Amy loci and the AP-4(1.0) and the LAP-1(.90) alleles show north south clinal change in frequency.
(14) On the other hand, grinding the glossy ridge-lap surface, painting the teeth with monomer or a solvent, preparing retention grooves on the ridge-lap portion of the teeth effectively lock the teeth to the denture base.
(15) We correlated Doppler variables of pulmonary venous flow and mitral inflow with simultaneously obtained mean LAP and changes in pressure measured by left atrial or pulmonary artery catheters.
(16) However, saccharin does not trigger a fixed rate of lapping at any point in the sequence.
(17) We might as well put a white cat in his lap.” The photographer asks McCluskey to hold the king up to the camera, and the press officer laughs with a wince.
(18) The race itself will feature 120 cyclists starting at 12.45pm and covering 13 laps of the Tour's finish circuit up and down the Champs Elysées, turning at Place de la Concorde and at the Arc de Triomphe, with a total distance of 90 kilometres.
(19) A significant LAP activity decrease was found only after a 30 day postcastration period when naloxone treated intact animals were compared with the castrated rats.
(20) These results suggest that P-LAP shows oxytocinase activity and plays an important role in the regulation of the plasma level of these hormones during pregnancy.