(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Nap
Definition:
(v. i.) To have a short sleep; to be drowsy; to doze.
(v. i.) To be in a careless, secure state.
(n.) A short sleep; a doze; a siesta.
(n.) Woolly or villous surface of felt, cloth, plants, etc.; an external covering of down, of short fine hairs or fibers forming part of the substance of anything, and lying smoothly in one direction; the pile; -- as, the nap of cotton flannel or of broadcloth.
(n.) The loops which are cut to make the pile, in velvet.
(v. t.) To raise, or put, a nap on.
Example Sentences:
(1) Effects of habitual variations in napping on psychomotor performance, short-term memory and subjective states were investigated.
(2) Of these 30-45% were of high affinity with a mean Kd value of 0.3 and 0.7 nM for GRO alpha and NAP-2, respectively, and 55-70% of low affinity (Kd = 30 nM).
(3) Stage REM frequently appeared within 10 min of stage 1 onset and the normal sequence of stages REM and 4 were altered, demonstrating that the organization of sleep within a nap is quite different from that in monophasic nocturnal sleep.
(4) During subsequent time off, napping and night sleep increased total sleep length above baseline levels.
(5) It is suggested that the modifier site is accessible to NAP-taurine only from the outside whereas the transport site may be accessible from either side.
(6) One service NAPS provides is a clip sheet of publication-ready newspaper columns complete with artwork which an editor can "clip" and use directly in a newspaper.
(7) Screening studies, from the most simple (night-time Holter monitor or ear oximetry) to either a carefully performed nap study or a home recording may aid in deciding which patients require a formal polysomnogram.
(8) Thus a large portion of Rp binding to NAP may represent nonspecific binding rather than binding to a finite number of Rp acceptor sites.
(9) By contrast, NAP did not affect these chondroformative processes.
(10) US supreme court justice Ruth Bader Ginsburg admitted that her traditional State of the Union nap may have been induced by a glass or two of wine.
(11) Some new data are presented about the clinical pathology of glossitis on the base of clinical, paraclinical, microbiological and virological studies and reliable possibilities of affecting by nistatin-prednisolone emulsion (NAP).
(12) Napping did not affect subsequent nocturnal sleep in either group.
(13) These observations suggest that our method can represent high NAP activity more exactly than NAP score and may be a potential tool in differentiating polycythemia vera from essential thrombocythemia.
(14) The late nap was more efficient in reducing sleepiness during the last 5 h of the experiments (23.00-04.00).
(15) The probable structures of the inclusion compounds of NAP with natural cyclodextrins were constructed using a molecular graphics program.
(16) This paper describes the 200-fold enrichment of the native RBF-2 class of PR acceptor sites beginning with the DNase I digestion of NAP to obtain DNase-resistant fragment (NAPf) containing approximately 150 bp of DNA.
(17) In contrast to G-CSF, GM-CSF did not affect the NAP activity in PMN in spite of the enhanced incorporation of amino acids into PMN by GM-CSF.
(18) Although anti-NH2SPD and anti-NAPS antibodies were identified that appeared to bind 3H-SPD, 3H-DOMP or 125I-IBZM with high affinity, none of the populations of polyclonal antibodies or monoclonal antibodies bound all three ligands with high affinity.
(19) In the dark, this compound, 8-methoxy-2-(N-n-propyl,N-3-(2-nitro-4-azidophenyl)aminopropyl) aminotetralin or 8-methoxy-3'-NAP-amino-PAT, displaced [3H]8-OH-DPAT and [3H]5-HT bound to 5-HT1A and 5-HT1 sites in hippocampal membranes with IC50 values of 6.6 and 18.1 nM respectively.
(20) Using highly purified CTAP-III as the substrate we studied the generation of NAP-2 by several neutral tissue proteinases.