(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Rap
Definition:
(n.) A lay or skein containing 120 yards of yarn.
(v. i.) To strike with a quick, sharp blow; to knock; as, to rap on the door.
(v. t.) To strike with a quick blow; to knock on.
(v. t.) To free (a pattern) in a mold by light blows on the pattern, so as to facilitate its removal.
(n.) A quick, smart blow; a knock.
(v.) To snatch away; to seize and hurry off.
(v.) To hasten.
(v.) To seize and bear away, as the mind or thoughts; to transport out of one's self; to affect with ecstasy or rapture; as, rapt into admiration.
(v.) To exchange; to truck.
(n.) A popular name for any of the tokens that passed current for a half-penny in Ireland in the early part of the eighteenth century; any coin of trifling value.
Example Sentences:
(1) The figures, published in the company’s annual report , triggered immediate anger from fuel poverty campaigners who noted that energy suppliers had just been rapped over the knuckles by the Competition and Markets Authority (CMA) for overcharging .
(2) Anxiety, depression, and somatization were greater in RAP mothers than well mothers.
(3) Now she also dabbles in playwriting and rap, and is in the band Sound of Rum .
(4) Renal autoregulation during decreases in renal arterial pressure (RAP) was examined in animals pretreated with a competitive antagonist of angiotensin ii, [1-sarcosine, 8-glycine] angiotensin II, or one of two chemically dissimilar inhibitors of prostaglandin synthetase, indomethacin and meclofenamate.
(5) To test this hypothesis, children with recurrent abdominal pain (RAP) with no identifiable organic cause were compared to children with an organic diagnosis for their abdominal pain, children with psychiatric disorders, and healthy controls.
(6) The fiery energy she radiated on stage and her motormouth, ragga-influenced raps brought her to the attention of So Solid Crew, who invited her to collaborate.
(7) In dogs with heart failure, PGE2 lowered the MAP and TPR and elevated the CO and SV without an effect on the RAP, PRC, and NE.
(8) Yet, in PX dogs infused simultaneously with amino acids and glucagon, RBF and GFR rose by 22 and 24%, respectively, at baseline RAP.
(9) On board Air Force One on the flight from Washington to New Orleans, Donna Brazile, the Democratic strategist, New Orleans native and former member of the Louisiana Recovery Authority, told reporters that Bush had gotten a bad rap for his handling of the recovery.
(10) His greatest passion on the trek up, apart from finding a 3G signal and playing rap music from a speaker on the back of his pack, was playing Tigers and Goats, a local version of chess, taking on all-comers – climbers, Sherpas, trekkers, random elderly porters passing through the lodges.
(11) The expression of ras p21 (as detected by RAP-5 and Y13-259) was noted in a wide range of cell types and tissues; intense immunostaining was noted in epithelial cells of the gastrointestinal tract, exocrine and endocrine pancreas, renal tubules and transitional urotheliem, as well as in other tissues.
(12) The analysis of the haemodymanic responses and the behaviour of many "contractility indices" of the right ventricle -- after acute intravenous injection of large doses of acetil-digoxin, in twelve patients with CPC caused by COLD with predominant clinical signs of emphysema (group A) or bronchitis (group B) -- showed an alarming, although transient, increase of the average pulmonary pressure (PAP), accompanied by rise of pulmonary arteriolar resistanced (RAP), especially in patients of the first group.
(13) Rap group Migos were stopped from riding their IO Hawks through a shopping centre when they launched their own clothing line, and Khalifa has used a similar device ( the PhunkeeDuck ) while shopping.
(14) Apart from that, nothing much to write home about, except that Whelan was lucky to escape a booking when he trod on Olivier Giroud's ankle and Erik Pieters possibly took the rap a few minutes later, picking up a caution for a less obvious foul on the same player.
(15) He rapped – he was introducing Dr Carson to his lyrics and what he raps about.” He quickly added that “it was clean rap; his lyrics were all clean.” The conversation was some time ago, Williams said, while Carson was still at Johns Hopkins.
(16) At rest, pulmonary artery (PAP), pulmonary wedge (PWP), and right atrial pressures (RAP) were reduced by 42%, 55% and 77%, respectively, after the first dose and by 26%, 32% and 45%, respectively, after the chronic (three weeks) treatment with BN.
(17) Reduction of RAP to 100 mmHg during CEI infusion caused SNGFR to decrease below control values in both OC and IC nephrons, and the autoregulation as found in control rats was impaired.
(18) Therefore, FK-506 interferes with an early event of T-cell activation that leads to apoptosis whereas RAP does not.
(19) In contrast, RAP did not modify the inhibitory effect of CsA on A23187-induced histamine release.
(20) Pitch A mix of hard-edged content – rap freestyles delivered straight to camera by attitude-heavy grime artists – and glitzier material: red-carpet reporting from movie premieres, backstage interviews with popstars and high-profile music videos.