(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Tap
Definition:
(v. t.) To strike with a slight or gentle blow; to touch gently; to rap lightly; to pat; as, to tap one with the hand or a cane.
(v. t.) To put a new sole or heel on; as, to tap shoes.
(n.) A gentle or slight blow; a light rap; a pat.
(n.) A piece of leather fastened upon the bottom of a boot or shoe in repairing or renewing the sole or heel.
(n.) A signal, by drum or trumpet, for extinguishing all lights in soldiers' quarters and retiring to bed, -- usually given about a quarter of an hour after tattoo.
(v. i.) To strike a gentle blow.
(n.) A hole or pipe through which liquor is drawn.
(n.) A plug or spile for stopping a hole pierced in a cask, or the like; a faucet.
(n.) Liquor drawn through a tap; hence, a certain kind or quality of liquor; as, a liquor of the same tap.
(n.) A place where liquor is drawn for drinking; a taproom; a bar.
(n.) A tool for forming an internal screw, as in a nut, consisting of a hardened steel male screw grooved longitudinally so as to have cutting edges.
(v. t.) To pierce so as to let out, or draw off, a fluid; as, to tap a cask, a tree, a tumor, etc.
(v. t.) Hence, to draw from (anything) in any analogous way; as, to tap telegraph wires for the purpose of intercepting information; to tap the treasury.
(v. t.) To draw, or cause to flow, by piercing.
(v. t.) To form an internal screw in (anything) by means of a tool called a tap; as, to tap a nut.
Example Sentences:
(1) Tap the relevant details into Google, though, and the real names soon appear before your eyes: the boss in question, stern and yet oddly quixotic, is Phyllis Westberg of Harold Ober Associates.
(2) A time course study using serially tapped guinea pig peritoneal cells is described.
(3) In the UK the twin threat of Ukip and the BNP tap into similar veins of discontent as their counterparts across the English channel.
(4) If you worship money and things - if they are where you tap real meaning in life - then you will never have enough.
(5) In order to clarify the development of mandibular movements associated with growth and development of the stomatognathic system, we compared the mandibular movements of children with normal occlusion at different Hellman's dental age between IIA and IIIB, during tooth tapping movements using the following 7 different kinds of frequency; ad lib.
(6) We examined the MLS, a motor performance test, in an extended form including assessment of "tapping" regularity for its practicability in therapy control of Parkinson's disease.
(7) We conclude that routine use of Golytely is preferable to methods involving catharsis and standard tap water enemas for barium enema examination, on the grounds that it is equally effective, yet more convenient for patients and for the radiology department, and reduces total costs.
(8) The surgical treatment was initiated with percutaneous subdural tapping which was repeated periodically, if indicated, for 2 weeks.
(9) The onset of tolerance to morphine analgesia was studied in 34 female Wistar rats immediately after they drank a dextrose-saccharin cocktail or tap water for 6 or 24 hours.
(10) Painless recovery of radiopaque substances after positive contrast myelography is often difficult, especially if the initial spinal tap is not made precisely in the midline.
(11) It’s about state sovereignty.” The BLM’s retreat vindicated his stance, he said, tapping a copy of the US constitution which he keeps in a breast pocket.
(12) Never leave a tap dripping - it can waste up to four litres a day.
(13) His balancing pole swayed uncontrollably, nearly tapping the sides of his feet.
(14) The power users and early adopters of these apps, the ones you're most likely to see tapping their thumbs over a tiny screen, are under 25.
(15) Der Spiegel magazine reported on Friday that Germany’s bid committee had tapped into a slush fund of €6.7m to buy votes at world football’s governing body Fifa.
(16) Past studies have shown that in normal non-depleted cats, somatosensory stimuli (forepaw tap) evoke both complex and simple spike responses.
(17) Citing information gathered from "intelligence services, witnesses and phone taps" he named the Liberal Democratic party of Russia (LDPR), an ultra-nationalist party in Russia's Duma.
(18) Dortmund seemed certain to score after Reus and Grosskreutz swapped passes on the edge of the area and Reuz tapped the ball into the path of Gundogan, charging in to meet it five yards out.
(19) While you can buy commercial formulations, I have always found that tap water, a cup of strong black tea, and some lemon juice provide enough nutrients for a lovely fermentation.
(20) This study investigates the mechanism of activation via the TAP molecule.