(1) In contrast, TTR(Met30) was relatively enriched in cerebrospinal fluid samples from two FAP patients.
(2) Haplotype analysis revealed that the Val----Met mutation has recurred frequently in the population to generate the FAP families of independent origins.
(3) An informative Dutch pedigree showed that two other linked polymorphic DNA markers, Pi227 and YN5.48, closely flank the FAP locus, one on either side.
(4) Studies of the molecular genetics of colon cancer have identified acquired alterations in oncogenes such as the K-ras gene and in putative tumor suppressor genes such as the FAP gene on chromosome 5, the p53 gene on chromosome 17, and the DCC gene on chromosome 18, which appear to mediate important steps in the adenoma-dysplasia-carcinoma sequence.
(5) The tumors themselves were FAP protein negative, as were the nonpancreatic tumors and normal organs.
(6) These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal.
(7) In FAP group (7 males and 5 females) the average age was 55 (range 30 to 74).
(8) Other probes, however, should be useful for assessing FAP inheritance by restriction fragment length polymorphism analysis, for presymptomatic diagnosis of the disease.
(9) Proteins with lower molecular weight than the PA monomer were major proteins in both SSA and FAP fibrils.
(10) Colchicine or Dimethyl-Sulphoxide (DMSO) treatment may prevent the development of FAP.
(11) Genomic DNA was isolated from peripheral blood lymphocytes of a patient with familial amyloidotic polyneuropathy (FAP) and the transthyretin (TTR) gene examined for sequence mutations.
(12) Patients with FAP develop multiple benign colorectal tumors.
(13) A recent study of FAP (5-FU, doxorubicin, cisplatin) has reported a 50% response rate with a significant number of CRs.
(14) Other dominantly-inherited colorectal cancer syndromes produce less striking phenotypes, but affect far more individuals than FAP.
(15) Sialic acid heterogeneity probably has a genetic basis, but this is not associated with the genetic defect underlying FAP.
(16) MF was found most often in FAP patients with associated extra-colonic "Gardner" signs (19 patients) and those who had had previous abdominal surgery (20 patients).
(17) This is the first report of chromosome 18 allele loss in colorectal carcinomas from FAP patients and concurrent allele losses on chromosomes 5 and 18 in sporadic colorectal cancer.
(18) Subsequent linkage analysis in six pedigrees, three having the FPC phenotype and three segregating GS, placed the FAP locus very close to a new marker, YN5.48 (D5S81), that is approximately 17 centimorgans distal to C11p11 on the genetic map.
(19) In a prospective study, 34 patients at 50% risk of inheriting FAP were examined.
(20) The coexistence of populations with severe duodenal and rectal polyposis suggests that environmental factors are important in phenotypic expression in FAP.
Wap
Definition:
(v. t. & i.) To beat; to whap.
(n.) A blow or beating; a whap.
Example Sentences:
(1) The Wap-ras gene was stably introduced into the mouse germ line of five transgenic mice (one male and four females).
(2) A parent who took his anti-Page 3 campaign to Legoland and Wapping is claiming victory after the Danish toymaker announced the end of its two-year partnership with the Sun.
(3) In contrast, the WAP mRNA was then rapidly accumulated.
(4) The expression of WAP appears to be dependent upon the formation of the alveoli-like spheres: prevention of sphere formation by fixation or drying of the matrix abolishes the expression of WAP.
(5) Even so, Dinsmore, known to colleagues in Scotland for being very cool and disciplined, was soon drafted down to Wapping to become the Sun's managing editor in London as new senior staff were brought in after the sudden closure of the News of the World.
(6) There was no announcement, however, of any other management changes at Wapping where speculation of a wider reorganisation and possible cost saving had surfaced after it emerged on Sunday that Mockridge was leaving.
(7) Contact between the owner of the Times and the Sun and Ofcom in the run-up to Christmas left insiders at News Corp's Wapping headquarters braced for a referral.
(8) Whey acidic protein (WAP) is a major whey protein in mouse milk.
(9) Position independence was restored following reinsertion of the WAP 3' UTR into the deleted construct at the same location, but only when the insertion was in the sense orientation.
(10) In addition the WAP gene must share, with other milk protein genes, elements that target gene expression to the mammary gland.
(11) Induction of the genes for WAP and beta-casein during development of mammary glands requires the synergistic action of insulin, hydrocortisone, and prolactin.
(12) These data indicate that the well-established amplificatory effect of glucocorticoids on casein gene expression is a slow process whereas their effect on the WAP gene is rapid.
(13) The whey acidic protein (WAP) gene is expressed in mammary epithelial cells at late pregnancy and throughout lactation.
(14) James is said to have asked Lachlan to accompany their father on his Wapping visit as he had other commitments.
(15) The UK has the chance to lead the way on this as we did in the 80s with the Wapping move but if we block it our media sector will suffer for years.
(16) That alone – the Wapping dispute – was enough to cause the entire newspaper industry to tear itself apart.
(17) A WAP-chloramphenicol acetyltransferase construct containing 2.5 kilobases of the 5'-flanking sequence of the WAP gene was stably transfected into HC11 cells.
(18) The whey acidic protein (WAP) is a major milk protein.
(19) Prolactin alone induced rapidly asl-and b-casein gene but not WAP gene.
(20) Replacement of 3' sequences, including the WAP poly(A) addition site, with simian virus 40 late poly(A) sequences resulted in an approximately 20-fold reduction in the expression of WAP mRNA in the mammary gland during lactation.